Individuals with autism spectrum conditions (ASC) have profound impairments in the interpersonal social domain, but it is unclear if individuals with ASC also have impairments in the intrapersonal self-referential domain. Lombardo et. al.
give an interesting introductory discussion of the "absent self" model of Frith. They then evaluate performance of 30 subjects and:
"conclude that individuals with ASC have broad impairments in both self-referential cognition and empathy. These two domains are also intrinsically linked and support predictions made by simulation theory. Our results also highlight a specific dysfunction in ASC within cortical midlines structures of the brain such as the medial prefrontal cortex."
Figure:. Image showing the overlap in peaks of activation from studies of self-referential cognition, other-referential cognition, and theory of mind within the medial prefrontal cortex and posterior cingulate/precuneus.
Boundaries are 16mm from within midline. All peaks are taken from exemplary studies in the literature. Brain is depicted on a representative sagittal slice of the Montreal Neurological Institute (MNI) template
Post a Comment