Friday, October 26, 2007

Brain changes after rehabilitation of congenital prosopagnosia

Another article on faces...Degutis et al. show MRI changes correlating with a recovery of enhanced amplitude of the N170 ERP (electroencephalogram event related potential)component in response to faces compared to objects after training of a subject with congenital prosopagnosia (face blindness).
We used functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to measure neural changes associated with training configural processing in congenital prosopagnosia, a condition in which face identification abilities are not properly developed in the absence of brain injury or visual problems. We designed a task that required discriminating faces by their spatial configuration and, after extensive training, prosopagnosic MZ significantly improved at face identification. Event-related potential results revealed that although the N170 was not selective for faces before training, its selectivity after training was normal. fMRI demonstrated increased functional connectivity between ventral occipital temporal face-selective regions (right occipital face area and right fusiform face area) that accompanied improvement in face recognition. Several other regions showed fMRI activity changes with training; the majority of these regions increased connectivity with face-selective regions. Together, the neural mechanisms associated with face recognition improvements involved strengthening early face-selective mechanisms and increased coordination between face-selective and nonselective regions, particularly in the right hemisphere.


  1. Anonymous5:37 PM

    Does anybody know what training technique was used here? Is it available? I would like to try it on myself as a medium-affected patient.

  2. I suggest you go to Google Scholar and look up articles by DeGutis, J.M., and D'Esposito, M. You will probably find their research websites also.