...In mice, sirtuin activators are effective against lung and colon cancer, melanoma, lymphoma, Type 2 diabetes, cardiovascular disease and Alzheimer’s disease...SRT-501, the company’s special formulation of resveratrol, is being tested against two cancers, multiple myeloma and colon cancer that has spread to the liver. A chemical mimic of resveratrol, known as SRT-2104, is in a Phase 2 trial for Type 2 diabetes, and in a Phase 1 trial in elderly patients. (Phase 1 trials test for safety, Phase 2 for efficacy.)...unpublished tests in mice showed that another chemical mimic, SRT-1720, increased both health and lifespan; after two years, twice as many mice taking the drug were alive compared with the undosed animals. Resveratrol itself has not been shown to increase lifespan in normal mice, although it does so in obese mice, laboratory roundworms and flies.
Tuesday, October 06, 2009
Long live quest gets respect? The 120 Club.
Nicholas Wade notes a recent meeting on aging at Harvard Medical School (Some of the participants belong to the "120 Club," whose members propose to live until they are 120). His article focuses on work of David Sinclair and Sirtris Pharmaceuticals .