The Flow Genome Project - modern snake oil? con?

Note added Aug.16, 2019.  Please see this update: https://mindblog.dericbownds.net/2019/08/a-schism-in-flow-land-flow-genome.html

I thought I would point MindBlog readers to comments made on my post of 11/7/2017, where I offered a scathing review of a book, "Stealing Fire" which purports to describe how the Flow Genome Project (for a considerable amount of money) will take you to the next level of human performance. The comments include an exchange between a very dissatisfied customer/student and a staff member in the first two classes offered ("Flow Fundamentals" and "Flow Performance.").   

Comment:

I read your commentary on the Flow Genome Project (FGP) with great interest. Your suspicions about this "effort" are spot on, and I wish that I had your insight before taking two of these classes from the FGP...The first class (Flow Fundamentals) was a great community of people, and I learned much from them, and nothing from the FGP personnel. The second class (Flow Performance) was pseudo-profound BS (PPBS.) There is a great paper that won an Ig Nobel Prize titled "On the reception and detection of pseudo-profound bullshit."...The paper perfectly described every aspect of this class!! The instructor - Jamie Wheal - is more interested in impressing people with PPBS than realaying any useful information. Also, each class is prefaced with the promise that "All the secrets of Stealing Fire will be revealed in this next class." I stopped when this promise was not delivered in Flow Performance; but, was promised for private coaching (at an extremely high price).

Response from Flow Genome Project:

We're actually re-launching our new website in the coming month or so to address and make more transparent the research we're working on. As for the links, that was a frustrating mistake with them being published without confirmation on the back end. The correct working links are:  

http://stealingfirebook.com/downloads
http://stealingfirebook.com/research 

[note inserted at this point by Bownds...the corrected links now actually work, but the web page /research contains no research,  and the web page /downloads is simply a sales pitch for buying the book "Stealing Fire"....their "correct working links" yield no relevant information!.].. continuing:
  

Sorry to hear Mike that you're still not satisfied with your experience in the course. Those marketing criticisms are puzzling as we unpacked quite a lot of information in Flow Performance with respect to that topic. The private coaching is not promising to deliver hidden information that Flow Performance does not, but rather the personal 1:1 time with a coach.

Response to the last sentence by commenter:

Here is an excerpt from an email from Jamie Wheal announcing the availability of private coaching to all members of the Flow Performance Class: 

"I’ve only ever done this with CEOs and military leaders, never before to the general public. We’re going to combine deep dive coaching, direct facilitation through some of our highest octane tools and a behind the curtain look at what we covered in Stealing Fire. No filter. Gloves off. The most potent tools and techniques we’ve learned in over a decade of working with the best in the world, and seeing what actually sticks." 

The VERY same promise made for Flow Performance. A promise that was never kept. I rest my case!!

Further comment:

During the Flow Performance Class, Jamie Wheal made the statement multiple times that "Stealing Fire [the book that he co-authored and the foundation for FGP training] is a complete fiction; a Promethean Prank." Taking him at his word, how can such a document have any scientific validity and/or application at all?! In addition, whenever a topic came up - in Flow Performance - in which certain class members had experience and deep understanding (e.g. Breathwork, DNA testing, Microdosing), the lack of knowledge/depth of understanding on the part of the FGP was blindingly obvious given the FGP's responses to deeper inquiries by those experts in the class. It is very telling when one starts addressing questions and concerns about their work with statements about their credentials, listing members of their network/inner circle, and engaging in character assassination against those who question; rather than addressing the questions directly. This was a constant problem during Flow Performance. It was the worst, but not the only, source of pseudo profound bullshit in the Flow Performance class.

The war for our attention - an existential threat.

I want to pass on some edited clips from an article by Casey Schwartz on fundamental threats to individual and societal well-being posed by the new “attention economy.”

Earlier this month, Facebook and Instagram announced new tools for users to set time limits on their platforms, and a dashboard to monitor one’s daily use, following Google’s introduction of Digital Well Being features…In doing so the companies seemed to suggest that spending time on the internet is not a desirable, healthy habit, but a pleasurable vice: one that if left uncontrolled may slip into unappealing addiction.

James Williams, a technologist turned philosopher has written a new book, “Stand Out of Our Light.” During a decade-long tenure at Google, he worked on search advertising, helping perfect a powerful, data-driven advertising model...Mr. Williams compares the current design of our technology to “an entire army of jets and tanks” aimed at capturing and keeping our attention. And the army is winning...This is us: eyes glazed, mouth open, neck crooked, trapped in dopamine loops and filter bubbles. Our attention is sold to advertisers, along with our data, and handed back to us tattered and piecemeal.

”In the same way that you pull out a phone to do something and you get distracted, and 30 minutes later you find that you’ve done 10 other things except the thing that you pulled out the phone to do — there’s fragmentation and distraction at that level,” he said. “But I felt like there’s something on a longer-term level that’s harder to keep in view: that longitudinal sense of what you’re about.”

The constant pull on our attention from technology is no longer just about losing too many hours of our so-called real lives to the diversions of the web. Now, they are telling us, we are at risk of fundamentally losing our moral purpose.

Tristan Harris, a former design ethicist for Google…has been playing the role of whistle-blower since he quit Google five years ago…he notes that the constant pull on our attention from technology…is changing our ability to make sense of what’s true, so we have less and less idea of a shared fabric of truth, of a shared narrative that we all subscribe to…Without shared truth or shared facts, you get chaos — and people can take control.

…a whole industry has sprung up to combat tech creep…HabitLab, developed at Stanford, stages aggressive interventions whenever you enter one of your self-declared danger zones of internet consumption…Like Moment, an app that monitors screen time and sends you or loved ones embarrassing notifications detailing exactly how much time has been frittered away on Instagram today, HabitLab gets to know your patterns uncomfortably well in order to do its job. Apparently, we now need our phones to save us from our phones. 

Researchers have known for years that there’s a difference between “top-down" attention (the voluntary, effortful decisions we make to pay attention to something of our choice) and “bottom-up” attention, which is when our attention is involuntarily captured by whatever is going on around us: a thunderclap, gunshot or merely the inviting bleep that announces another Twitter notification.

At Tufts University, Nick Seaver, an anthropology professor, just finished his second year of teaching a class he designed called How to Pay Attention…Dr...Seaver, 32, is no Luddite… “Information overload is something that always feels very new but is actually very old..It is the 16th century, and there are so many books; or it is late antiquity and there is so much writing...It can’t be that there are too many things to pay attention to: That doesn’t follow...But it could be that there are more things that are trying to actively demand your attention.”

Sherry Turtle, M.I.T. sociologist and psychologist:…there is not only the attention we pay to consider, but also the attention we receive…Rather than compete with their siblings for their parents’ attention, children are up against iPhones and iPads, Siri and Alexa, Apple watches and computer screens…A generation has grown up that has lived a very unsatisfying youth and really does not associate their phones with any kind of glamour, but rather with a sense of deprivation.

We’re starting to see people inching their way toward ‘time well spent,’ Apple inching its way toward a mea culpa…And the culture itself turning toward a recognition that this can’t go on.

Infants distinguish between leaders and bullies

From Margoni et al:

We examined whether 21-month-old infants could distinguish between two broad types of social power: respect-based power exerted by a leader (who might be an authority figure with legitimate power, a prestigious individual with merited power, or some combination thereof) and fear-based power exerted by a bully. Infants first saw three protagonists interact with a character who was either a leader (leader condition) or a bully (bully condition). Next, the character gave an order to the protagonists, who initially obeyed; the character then left the scene, and the protagonists either continued to obey (obey event) or no longer did so (disobey event). Infants in the leader condition looked significantly longer at the disobey than at the obey event, suggesting that they expected the protagonists to continue to obey the leader in her absence. In contrast, infants in the bully condition looked equally at the two events, suggesting that they viewed both outcomes as plausible: The protagonists might continue to obey the absent bully to prevent further harm, or they might disobey her because her power over them weakened in her absence. Additional results supported these interpretations: Infants expected obedience when the bully remained in the scene and could harm the protagonists if defied, but they expected disobedience when the order was given by a character with little or no power over the protagonists. Together, these results indicate that by 21 months of age, infants already hold different expectations for subordinates’ responses to individuals with respect-based as opposed to fear-based power.

Giving Ecstasy to Octopuses

Edsinger and Dölen have found out how to make the normally shy and retiring octopus into a party animal. They found that MDMA (phenethylamine (+/−)-3,4-methylendioxymethamphetamine, also known as Ecstasy) has prosocial effects, just as it does in humans. The indicates that the role of the serotonergic neurotransmission (that MDMA acts on) in regulating social behaviors has been evolutionarily conserved over 500 million years.

Human and octopus lineages are separated by over 500 million years of evolution and show divergent anatomical patterns of brain organization. Despite these differences, growing evidence suggests that ancient neurotransmitter systems are shared across vertebrate and invertebrate species and in many cases enable overlapping functions. Sociality is widespread across the animal kingdom, with numerous examples in both invertebrate (e.g., bees, ants, termites, and shrimps) and vertebrate (e.g., fishes, birds, rodents, and primates) lineages [6]. Serotonin is an evolutionarily ancient molecule that has been implicated in regulating both invertebrate and vertebrate social behaviors, raising the possibility that this neurotransmitter’s prosocial functions may be conserved across evolution. Members of the order Octopoda are predominantly asocial and solitary. Although at this time it is unknown whether serotonergic signaling systems are functionally conserved in octopuses, ethological studies indicate that agonistic behaviors are suspended during mating, suggesting that neural mechanisms subserving social behaviors exist in octopuses but are suppressed outside the reproductive period. Here we provide evidence that, as in humans, the phenethylamine (+/−)-3,4-methylendioxymethamphetamine (MDMA) enhances acute prosocial behaviors in Octopus bimaculoides. This finding is paralleled by the evolutionary conservation of the serotonin transporter (SERT, encoded by the Slc6A4 gene) binding site of MDMA in the O. bimaculoides genome. Taken together, these data provide evidence that the neural mechanisms subserving social behaviors exist in O. bimaculoides and indicate that the role of serotonergic neurotransmission in regulating social behaviors is evolutionarily conserved.

Building molecular machines.

In an open source PNAS news article, Stephen Ornes describes efforts to build molecular machines modeled on our own biochemical processes - possibly artificial muscles or molecular electronics. It makes a fascinating read. A few clips:

Some of the smallest, most useful machines known to science are the biological molecules that keep living things living. The protein myosin drives the contraction and relaxation of muscle. Kinesin drags cellular cargo around the cell. Motor enzymes unwind, rewind, and maintain DNA, and bacteria use a molecular motor to rotate their whip-like flagella up to 100,000 times per minute, propelling them forward. These machines turn chemical energy into motion. They’re very efficient at their jobs.

The idea of using molecules to build minuscule machines that perform useful tasks dates back at least to a lecture given in 1959 by physicist Richard Feynman titled “There’s Plenty of Room at the Bottom.”* More recently, demonstrations of artificial molecular machines offer good reasons to think that such devices are feasible. Researchers have forged motors, shuttles, elevators, walkers, and pumps out of molecules, and powered them with electrical energy, chemical reactions, or light. Tiny motor by tiny motor, these demonstrations are inching toward future applications that could range from molecular electronics to artificial muscles.

...molecular machines are by nature floppy, like the soft matter that makes up the human body, whereas macroscopic machines are typically made from rigid materials such as metal. But it’s also a consequence of scale. Although the laws of physics don’t change in the nanoworld, their relative influences do. Concepts such as inertia and momentum—critical to the design of machines like cars and planes—become irrelevant. So does gravity, because molecules have such a small mass. Movement at the nanoscale is dominated instead by viscosity and Brownian motion, the random bumbling of individual molecules caused by thermal fluctuations...Katsonis calls this molecular environment a “Brownian storm.” In a 2007 article on the physics of nanoscale machines, physicist R. Dean Astumian at the University of Maine in Orono, ME, likened the challenges to swimming in molasses and walking in a hurricane.

The article gives numerous examples of efforts to develop nanoscale motors driven by electrical energy, chemical energy, or light.

Mapping our subjective feelings.

Nummenmaa et al.  do a massive job of data gathering whose purpose left me scratching my head on first sight...wondering why such an effort is useful.  But then, if someone asked me how I would describe my subjective experience  I wouldn't know where to start.  In the introduction to their open source article they "use the word feeling to simply refer to the current, subjectively accessible phenomenological state of an individual...Despite the centrality of subjective feelings to ourselves and our conscious well-being, the relative organization and determinants of different feelings have remained poorly understood. "  I pass on their abstract and a summary graphic from the article.

Significance

Subjective feelings are a central feature of human life, yet their relative organization has remained elusive. We mapped the “human feeling space” for 100 core feelings ranging from cognitive and affective processes to somatic sensations; in the analysis, we combined basic dimension rating, similarity mapping, bodily sensation mapping, and neuroimaging meta-analysis. All feelings were emotionally loaded, and saliencies of bodily and mental experiences were correlated. Feelings formed five groups: positive emotions, negative emotions, cognitive processes, somatic states, and homeostatic states. Feeling space was best explained by emotionality, mental experience, and bodily sensation topographies. Subjectively felt similarity of feelings was associated with basic feeling dimensions and the bodily sensation maps. This shows that subjective feelings are categorical, emotional, and embodied.

 Abstract

Subjective feelings are a central feature of human life. We defined the organization and determinants of a feeling space involving 100 core feelings that ranged from cognitive and affective processes to somatic sensations and common illnesses. The feeling space was determined by a combination of basic dimension rating, similarity mapping, bodily sensation mapping, and neuroimaging meta-analysis. A total of 1,026 participants took part in online surveys where we assessed (i) for each feeling, the intensity of four hypothesized basic dimensions (mental experience, bodily sensation, emotion, and controllability), (ii) subjectively experienced similarity of the 100 feelings, and (iii) topography of bodily sensations associated with each feeling. Neural similarity between a subset of the feeling states was derived from the NeuroSynth meta-analysis database based on the data from 9,821 brain-imaging studies. All feelings were emotionally valenced and the saliency of bodily sensations correlated with the saliency of mental experiences associated with each feeling. Nonlinear dimensionality reduction revealed five feeling clusters: positive emotions, negative emotions, cognitive processes, somatic states and illnesses, and homeostatic states. Organization of the feeling space was best explained by basic dimensions of emotional valence, mental experiences, and bodily sensations. Subjectively felt similarity of feelings was associated with basic feeling dimensions and the topography of the corresponding bodily sensations. These findings reveal a map of subjective feelings that are categorical, emotional, and embodied.

Here is their two dimensional map of feeling space (click to enlarge, or better, click link to original open source article.)

Details of how a fear response is unlearned.

Learning requires the formation of new nerve connections. When that learning is extinguished are those connections inhibited or lost? Wan Lai et al. provide evidence for the latter:

Significance

Whether learning-induced changes in neuronal circuits are inhibited or erased during the process of unlearning remains unclear. In this study, we examined the impact of auditory-cued fear conditioning and extinction on the remodeling of synaptic connections in the living mouse auditory cortex. We found that fear conditioning leads to cue-specific formation of new postsynaptic dendritic spines, whereas fear extinction preferentially eliminates these new spines in a cue-specific manner. Our findings suggest that learning-related changes of synaptic connections in the cortex are at least partially reversed after unlearning.

Abstract

Fear conditioning-induced behavioral responses can be extinguished after fear extinction. While fear extinction is generally thought to be a form of new learning, several lines of evidence suggest that neuronal changes associated with fear conditioning could be reversed after fear extinction. To better understand how fear conditioning and extinction modify synaptic circuits, we examined changes of postsynaptic dendritic spines of layer V pyramidal neurons in the mouse auditory cortex over time using transcranial two-photon microscopy. We found that auditory-cued fear conditioning induced the formation of new dendritic spines within 2 days. The survived new spines induced by fear conditioning with one auditory cue were clustered within dendritic branch segments and spatially segregated from new spines induced by fear conditioning with a different auditory cue. Importantly, fear extinction preferentially caused the elimination of newly formed spines induced by fear conditioning in an auditory cue-specific manner. Furthermore, after fear extinction, fear reconditioning induced reformation of new dendritic spines in close proximity to the sites of new spine formation induced by previous fear conditioning. These results show that fear conditioning, extinction, and reconditioning induce cue- and location-specific dendritic spine remodeling in the auditory cortex. They also suggest that changes of synaptic connections induced by fear conditioning are reversed after fear extinction.

Exposure to opposing views on social media can increase political polarization.

A sobering study by Bail et al. (open source) shows that just getting us out of our tribes' social media echo chambers does not have the palliative softening effect commonly supposed, but rather increases political polarization:

Significance

Social media sites are often blamed for exacerbating political polarization by creating “echo chambers” that prevent people from being exposed to information that contradicts their preexisting beliefs. We conducted a field experiment that offered a large group of Democrats and Republicans financial compensation to follow bots that retweeted messages by elected officials and opinion leaders with opposing political views. Republican participants expressed substantially more conservative views after following a liberal Twitter bot, whereas Democrats’ attitudes became slightly more liberal after following a conservative Twitter bot—although this effect was not statistically significant. Despite several limitations, this study has important implications for the emerging field of computational social science and ongoing efforts to reduce political polarization online.

Abstract

There is mounting concern that social media sites contribute to political polarization by creating “echo chambers” that insulate people from opposing views about current events. We surveyed a large sample of Democrats and Republicans who visit Twitter at least three times each week about a range of social policy issues. One week later, we randomly assigned respondents to a treatment condition in which they were offered financial incentives to follow a Twitter bot for 1 month that exposed them to messages from those with opposing political ideologies (e.g., elected officials, opinion leaders, media organizations, and nonprofit groups). Respondents were resurveyed at the end of the month to measure the effect of this treatment, and at regular intervals throughout the study period to monitor treatment compliance. We find that Republicans who followed a liberal Twitter bot became substantially more conservative posttreatment. Democrats exhibited slight increases in liberal attitudes after following a conservative Twitter bot, although these effects are not statistically significant. Notwithstanding important limitations of our study, these findings have significant implications for the interdisciplinary literature on political polarization and the emerging field of computational social science.

How exercise slows Alzheimer’s disease.

Wow…if I ever needed more encouragement to keep up my exercise routines (mainly swimming, biking, and a few weights) Choi et al. provide it by demonstrating that in a mouse model of Alzheimer's disease, exercise improves memory through a combination of encouraging the generation of new nerve cells in the hippocampus and increasing the levels of brain-derived neurotrophic factor (BDNF) that supports neuronal growth and survival. Their abstract:

Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer’s disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased AHN, ameliorated cognition. We successfully mimicked the beneficial effects of exercise on AD mice by genetically and pharmacologically inducing AHN in combination with elevating BDNF levels. Suppressing AHN later led to worsened cognitive performance and loss of preexisting dentate neurons. Thus, pharmacological mimetics of exercise, enhancing AHN and elevating BDNF levels, may improve cognition in AD. Furthermore, applied at early stages of AD, these mimetics may protect against subsequent neuronal cell death.

Robots R Us

Two recent NYTimes pieces - one by Sherry Turtle (professor in the program in Science, Technology and Society at M.I.T.) and the other by Andy Clark (professor of logic and metaphysics at the University of Edinburgh) - lay out starkly opposing views of the desirability of humans moving toward increased interactions with, and possible enhancements by, robots. You should read both. Turtle sees a potential diminution of our humanity:

The narrative begins with the idea that companionate robots would be “better than nothing,” better because there aren’t enough people to teach, love and tend to people. But that idea quickly shifts into another: robots would be better than most anything. Unlike people, they would not abandon you or get sick and die. They might not be capable of love, but they won’t break your heart. From better than nothing to better than anything. These are stations on our voyage to forgetting what it means to be human. But the forgetting begins long before we have a robot companion in place; it begins when we even think of putting one in place. To build the robots, we must first rebuild ourselves as people ready to be their companions.

Clark looks towards a glorious enhancement of what it means to be human. He begins with a list that includes improving normal mental functioning and generating a wide spectrum of ways of being:

We now glimpse the next steps in human cultural and cognitive evolution, continuing the trend that started with the arrival of human language and the (much later) invention of writing and the external storage and transmission of ideas. The new steps herald an age of fluidity and demand answers to a host of questions…The two most important such questions are simply: How should we negotiate this dauntingly large space of human possibility? And what costs are we willing to tolerate along the way?

The first is a question of practice, the second of ethics. Practically speaking, it will not be easy to decide in a world of so many possible ways of being, so many enhancements and augmentations, and so many social practices, which ones are for us. 

Ethically speaking, we need to ask what new costs and inequalities the freedoms and augmentations of some may mean for others. We need to ask if we are willing to tolerate some inequality as part of the rollout process for a more fluid and interconnected world. Issues of privacy and the right to control (including to trade or sell) our personal information are vividly with us. Not knowing quite where we as protected selves stop and the world around us begins, law and policy struggle to decide if (for example) information stored on our phones is enough like information stored in our heads to warrant the same protections. Law, education and social policy currently lag behind many interacting waves of change. What is up for grabs is what we humans are, and what we will become.

(Note,

MindBlog is on vacation Aug. 31 - Sept. 22

Deric and Len just arrived in Amsterdam today. We will hang out here for a few days before getting on a Viking river boat cruise from Amsterdam to Budapest, Sept. 4 - Sept. 18.  MindBlog posts will probably be infrequent or absent until late September.  Having banged out 4,522  posts since MindBlog's start in 2006, maybe it's time for a break!

Collective intelligence is improved by intermittent breaks in interaction.

Interesting work from Bernstein, Shore, and Lazer:

Significance

Many human endeavors—from teams and organizations to crowds and democracies—rely on solving problems collectively. Prior research has shown that when people interact and influence each other while solving complex problems, the average problem-solving performance of the group increases, but the best solution of the group actually decreases in quality. We find that when such influence is intermittent it improves the average while maintaining a high maximum performance. We also show that storing solutions for quick recall is similar to constant social influence. Instead of supporting more transparency, the results imply that technologies and organizations should be redesigned to intermittently isolate people from each other’s work for best collective performance in solving complex problems.

Abstract

People influence each other when they interact to solve problems. Such social influence introduces both benefits (higher average solution quality due to exploitation of existing answers through social learning) and costs (lower maximum solution quality due to a reduction in individual exploration for novel answers) relative to independent problem solving. In contrast to prior work, which has focused on how the presence and network structure of social influence affect performance, here we investigate the effects of time. We show that when social influence is intermittent it provides the benefits of constant social influence without the costs. Human subjects solved the canonical traveling salesperson problem in groups of three, randomized into treatments with constant social influence, intermittent social influence, or no social influence. Groups in the intermittent social-influence treatment found the optimum solution frequently (like groups without influence) but had a high mean performance (like groups with constant influence); they learned from each other, while maintaining a high level of exploration. Solutions improved most on rounds with social influence after a period of separation. We also show that storing subjects’ best solutions so that they could be reloaded and possibly modified in subsequent rounds—a ubiquitous feature of personal productivity software—is similar to constant social influence: It increases mean performance but decreases exploration.

Robots exert peer pressure on children, but not adults.

From Vollmer et al.:

People are known to change their behavior and decisions to conform to others, even for obviously incorrect facts. Because of recent developments in artificial intelligence and robotics, robots are increasingly found in human environments, and there, they form a novel social presence. It is as yet unclear whether and to what extent these social robots are able to exert pressure similar to human peers. This study used the Asch paradigm, which shows how participants conform to others while performing a visual judgment task. We first replicated the finding that adults are influenced by their peers but showed that they resist social pressure from a group of small humanoid robots. Next, we repeated the study with 7- to 9-year-old children and showed that children conform to the robots. This raises opportunities as well as concerns for the use of social robots with young and vulnerable cross-sections of society; although conforming can be beneficial, the potential for misuse and the potential impact of erroneous performance cannot be ignored.

Reversing age related decay of brain plasticity with prozac

Eavri et al. find that treatment of mice with fluoxetine as they are aging slows the decline of several brain plasticity makers. Even if shown to have the same effects in humans, Fluoxetine would probably not be a realistic therapeutic agent for aging humans because it would have to be taken from an early age and is not recommended for use in the elderly due to its side effects. Here is their technical abstract:

Changes in excitatory neuron and synapse structure have been recognized as a potential physical source of age-related cognitive decline. Despite the importance of inhibition to brain plasticity, little is known regarding aging associated changes to inhibitory neurons. Here we test for age-related cellular and circuit changes to inhibitory neurons of mouse visual cortex. We find no substantial difference in inhibitory neuron number, inhibitory neuronal subtypes, or synapse numbers within the cerebral cortex of aged mice as compared to younger adults. However, when comparing cortical interneuron morphological parameters, we find differences in complexity, suggesting that arbors are simplified in aged mice. In vivo two-photon microscopy has previously shown that in contrast to pyramidal neurons, inhibitory interneurons retain a capacity for dendritic remodeling in the adult. We find that this capacity diminishes with age and is accompanied by a shift in dynamics from balanced branch additions and retractions to progressive prevalence of retractions, culminating in a dendritic arbor that is both simpler and more stable. Recording of visually evoked potentials (VEPs) shows that aging-related interneuron dendritic arbor simplification and reduced dynamics go hand in hand with loss of induced stimulus-selective response potentiation (SRP), a paradigm for adult visual cortical plasticity. Chronic treatment with the antidepressant fluoxetine reversed deficits in interneuron structural dynamics and restored SRP in aged animals. Our results support a structural basis for age related impairments in sensory perception, and suggest that declines in inhibitory neuron structural plasticity during aging contribute to reduced functional plasticity.

On the reception and detection of pseudo-profound bullshit

I want to thank MindBlog reader Mike Walterman, who sent me an email pointing me to this article (which won an Ig Nobel Prize) and commented on his experience with "Flow Genome Project" which I reviewed in a Nov. 17, 2017 post titled "Modern flimflam men? - The Flow Genome Project". In commenting on this post, Mike described his experience of signing on for some classes with FGP:

I read your commentary on the Flow Genome Project (FGP) with great interest. Your suspicions about this "effort" are spot on, and I wish that I had your insight before taking two of these classes from the FGP. By the way, Steven Kotler is an alum of UW-Madison!!

The first class (Flow Fundamentals) was a great community of people, and I learned much from them, and nothing from the FGP personnel. The second class (Flow Performance) was pseudo-profound BS (PPBS.) There is a great paper that won an Ig Nobel Prize titled "On the reception and detection of pseudo-profound bullshit." ... The paper perfectly described every aspect of this class!! The instructor - Jamie Wheal - is more interested in impressing people with PPBS than realaying any useful information. Also, each class is prefaced with the promise that "All the secrets of Stealing Fire will be revealed in this next class." I stopped when this promise was not delivered in Flow Performance; but, was promised for private coaching (at an extremely high price).

Here is the abstract from the Pennycook et al. article on pseudo-profound bullshit:

Although bullshit is common in everyday life and has attracted attention from philosophers, its reception (critical or ingenuous) has not, to our knowledge, been subject to empirical investigation. Here we focus on pseudo-profound bullshit, which consists of seemingly impressive assertions that are presented as true and meaningful but are actually vacuous. We presented participants with bullshit statements consisting of buzzwords randomly organized into statements with syntactic structure but no discernible meaning (e.g., “Wholeness quiets infinite phenomena”). Across multiple studies, the propensity to judge bullshit statements as profound was associated with a variety of conceptually relevant variables (e.g., intuitive cognitive style, supernatural belief). Parallel associations were less evident among profundity judgments for more conventionally profound (e.g., “A wet person does not fear the rain”) or mundane (e.g., “Newborn babies require constant attention”) statements. These results support the idea that some people are more receptive to this type of bullshit and that detecting it is not merely a matter of indiscriminate skepticism but rather a discernment of deceptive vagueness in otherwise impressive sounding claims. Our results also suggest that a bias toward accepting statements as true may be an important component of pseudo-profound bullshit receptivity.

The architecture of pride is a cultural universal.

Sznycer et al. provide evidence that the pride system of WEIRD (western-ized, educated, industrialized, rich, and democratic) societies is found in 10 small-scale societies scattered across Central and South America, Africa, and Asia:

Significance

It has been proposed that one key function of pride is to guide behavior in ways that would increase others’ valuation of the individual. To incline choice, the pride system must compute for a potential action an anticipated pride intensity that tracks the magnitude of the approval or deference that the action would generate among local audiences. Data from industrial mass societies support this expectation. However, it is presently not known whether those data reflect cultural evolutionary processes or a panhuman adaptation. Experiments conducted in 10 traditional small-scale societies with widely varying cultures and subsistence modes replicate the pattern observed in mass societies. This suggests that pride is a universal system that is part of our species’ cooperative biology.

Abstract

Becoming valuable to fellow group members so that one would attract assistance in times of need is a major adaptive problem. To solve it, the individual needs a predictive map of the degree to which others value different acts so that, in choosing how to act, the payoff arising from others’ valuation of a potential action (e.g., showing bandmates that one is a skilled forager by pursuing a hard-to-acquire prey item) can be added to the direct payoff of the action (e.g., gaining the nutrients of the prey captured). The pride system seems to incorporate all of the elements necessary to solve this adaptive problem. Importantly, data from western(-ized), educated, industrialized, rich, and democratic (WEIRD) societies indicate close quantitative correspondences between pride and the valuations of audiences. Do those results generalize beyond industrial mass societies? To find out, we conducted an experiment among 567 participants in 10 small-scale societies scattered across Central and South America, Africa, and Asia: (i) Bosawás Reserve, Nicaragua; (ii) Cotopaxi, Ecuador; (iii) Drâa-Tafilalet, Morocco; (iv) Enugu, Nigeria; (v) Le Morne, Mauritius; (vi) La Gaulette, Mauritius; (vii) Tuva, Russia; (viii) Shaanxi and Henan, China; (ix) farming communities in Japan; and (x) fishing communities in Japan. Despite widely varying languages, cultures, and subsistence modes, pride in each community closely tracked the valuation of audiences locally (mean r = +0.66) and even across communities (mean r = +0.29). This suggests that the pride system not only develops the same functional architecture everywhere but also operates with a substantial degree of universality in its content.

Our divided brains

I just came across an engaging video made by British psychiatrist Iain McGilchrist, and want to pass it on to MindBlog readers:

Brain tracking of musical beat is enhanced by low frequency sounds.

Lenc et al. find that that brain activity at the frequency of the perceived beat is selectively enhanced compared with other frequencies in the electroencephalogram (EEG) spectrum when rhythms are conveyed by bass sounds, explaining why across cultures bass instruments are used to induce people to dance to periodic pulse-like beats.

Music makes us move, and using bass instruments to build the rhythmic foundations of music is especially effective at inducing people to dance to periodic pulse-like beats. Here, we show that this culturally widespread practice may exploit a neurophysiological mechanism whereby low-frequency sounds shape the neural representations of rhythmic input by boosting selective locking to the beat. Cortical activity was captured using electroencephalography (EEG) while participants listened to a regular rhythm or to a relatively complex syncopated rhythm conveyed either by low tones (130 Hz) or high tones (1236.8 Hz). We found that cortical activity at the frequency of the perceived beat is selectively enhanced compared with other frequencies in the EEG spectrum when rhythms are conveyed by bass sounds. This effect is unlikely to arise from early cochlear processes, as revealed by auditory physiological modeling, and was particularly pronounced for the complex rhythm requiring endogenous generation of the beat. The effect is likewise not attributable to differences in perceived loudness between low and high tones, as a control experiment manipulating sound intensity alone did not yield similar results. Finally, the privileged role of bass sounds is contingent on allocation of attentional resources to the temporal properties of the stimulus, as revealed by a further control experiment examining the role of a behavioral task. Together, our results provide a neurobiological basis for the convention of using bass instruments to carry the rhythmic foundations of music and to drive people to move to the beat.

The false idols of wellness.

Jen Gunter does an engaging take-down of the wellness-industrial complex in a NYTimes piece. She suggests that the wellness industry is exploiting rather than filling the gaps left by normal medical practice.:

Wellness used to mean a blend of health and happiness...it has become a false antidote to the fear of modern life and death...The wellness industry takes medical terminology, such as “inflammation” or “free radicals,” and levigates it to the point of incomprehension. The resulting product is a D.I.Y. medicine for longevity that comes with a confidence that science can only aspire to achieve.

...take the trend of adding a pinch of activated charcoal to your food or drink...it’s sold as a supposed “detox.”..It has the same efficacy as a spell from the local witch...“Toxins,” as defined by the peddlers of these dubious cures, are the harmful effluvia of modern life that supposedly roam our bodies...for without these toxins there can be no search for purity — “clean” tampons, “clean” food, “clean” makeup. There are also sacred acts and rituals to follow...Medicine and religion have long been deeply intertwined, and it’s only relatively recently that they have separated. The wellness-industrial complex seeks to resurrect that connection. It’s like a medical throwback, as if the halcyon days of health were 5,000 years ago. Ancient cleansing rituals with a modern twist — supplements, useless products and scientifically unsupported tests.

The dietary supplements that are the backbone of wellness make up a $30 billion a year business despite studies showing they have no value for longevity...So what’s the harm of spending money on charcoal for nonexistent toxins or vitamins for expensive urine or grounding bedsheets to better connect you with the earth’s electrons?..Here’s what: the placebo effect or “trying something natural” can lead people with serious illnesses to postpone effective medical care.

Moving the kind of product that churns the wheels of the wellness-industrial complex requires a constant stream of fear and misinformation. Look closer at most wellness sites and at many of their physician partners, and you’ll find a plethora of medical conspiracy theories: Vaccines and autism. The dangers of water fluoridation. Bras and breast cancer. Cellphones and brain cancer. Heavy metal poisoning. AIDS as a construct of Big Pharma.

There are symptoms that I believe have been with us since the beginning of time, so common that they are likely part of the human experience: fatigue, bloat, low libido, episodic pain, loss of vigor. When medicine can only offer a therapy, not a cure, or when doctors give undesired answers — suggesting attention to sleep hygiene, for instance — it isn’t hard to see how the intoxicating confidence and theater of wellness could beckon.

I admit that doctors can learn something from wellness. It’s clear that some people are looking for healers, so we must find ways to serve that need that are medically ethical...We doctors can do more to provide factual information about hazardous substances, such as carcinogens and endocrine disrupting chemicals, in products and the environment from medically vetted sites with no products to sell, such as the National Cancer Institute and the Endocrine Society...Many people — women especially — have long been marginalized and dismissed by medicine, but the answer does not lie in predatory conspiracy theories, a faux religion or expensive magic.

Mesolimbic reward circuitry influences valuation of knowledge versus ignorance.

From Charpentier et al.:

The pursuit of knowledge is a basic feature of human nature. However, in domains ranging from health to finance people sometimes choose to remain ignorant. Here, we show that valence is central to the process by which the human brain evaluates the opportunity to gain information, explaining why knowledge may not always be preferred. We reveal that the mesolimbic reward circuitry selectively treats the opportunity to gain knowledge about future favorable outcomes, but not unfavorable outcomes, as if it has positive utility. This neural coding predicts participants’ tendency to choose knowledge about future desirable outcomes more often than undesirable ones, and to choose ignorance about future undesirable outcomes more often than desirable ones. Strikingly, participants are willing to pay both for knowledge and ignorance as a function of the expected valence of knowledge. The orbitofrontal cortex (OFC), however, responds to the opportunity to receive knowledge over ignorance regardless of the valence of the information. Connectivity between the OFC and mesolimbic circuitry could contribute to a general preference for knowledge that is also modulated by valence. Our findings characterize the importance of valence in information seeking and its underlying neural computation. This mechanism could lead to suboptimal behavior, such as when people reject medical screenings or monitor investments more during bull than bear markets.

Meditation quiets the ego? ….maybe just the opposite.

From Gebauer et al.. In their abstract "self-enhancement bias" refers to exaggerated self views or valuations.

Mind-body practices enjoy immense public and scientific interest. Yoga and meditation are highly popular. Purportedly, they foster well-being by curtailing self-enhancement bias. However, this “ego-quieting” effect contradicts an apparent psychological universal, the self-centrality principle. According to this principle, practicing any skill renders that skill self-central, and self-centrality breeds self-enhancement bias. We examined those opposing predictions in the first tests of mind-body practices’ self-enhancement effects. In Experiment 1, we followed 93 yoga students over 15 weeks, assessing self-centrality and self-enhancement bias after yoga practice (yoga condition, n = 246) and without practice (control condition, n = 231). In Experiment 2, we followed 162 meditators over 4 weeks (meditation condition: n = 246; control condition: n = 245). Self-enhancement bias was higher in the yoga (Experiment 1) and meditation (Experiment 2) conditions, and those effects were mediated by greater self-centrality. Additionally, greater self-enhancement bias mediated mind-body practices’ well-being benefits. Evidently, neither yoga nor meditation fully quiet the ego; to the contrary, they boost self-enhancement.

The neuroscience of pessimism.

Ann Graybiel and collaborators offer a fascinating study showing that stimulation of the brain's caudate nucleus induces persistent and repetitive negative decision making. They devised a cost-benefit situation in which monkeys were offered a reward of juice paired with an unpleasant puff of air to the face. When the caudate nucleus was stimulated the animals began to avoid choosing the reward, when previously they would have put up with the unpleasant stimulus. This suggests that pessimistic decision-making can be tied to an overactive caudate nucleus. Work is now beginning with human patients suffering from anxiety and depression to find out whether abnormal activity in the caudate nucleus can be seen during negative decision making.

Highlights

Caudate nucleus stimulation induces persistent state change affecting value evaluation 

CN stimulation produces repetitive choices, whereas pACC stimulation does not 

CN beta oscillations parallel negative states influencing repetitive decisions 

Abnormal CN beta oscillations are correlated with persistency in OCD-like states

Summary P

ersistent thoughts inducing irrationally pessimistic and repetitive decisions are often symptoms of mood and anxiety disorders. Regional neural hyperactivities have been associated with these disorders, but it remains unclear whether there is a specific brain region causally involved in these persistent valuations. Here, we identified potential sources of such persistent states by microstimulating the striatum of macaques performing a task by which we could quantitatively estimate their subjective pessimistic states using their choices to accept or reject conflicting offers. We found that this microstimulation induced irrationally repetitive choices with negative evaluations. Local field potentials recorded in the same microstimulation sessions exhibited modulations of beta-band oscillatory activity that paralleled the persistent negative states influencing repetitive decisions. These findings demonstrate that local striatal zones can causally affect subjective states influencing persistent negative valuation and that abnormal beta-band oscillations can be associated with persistency in valuation accompanied by an anxiety-like state.

More evidence against the transferable benefits of online brain training on cognitive function

From Stojanoski et al.:

There is strong incentive to improve our cognitive abilities, and brain training has emerged as a promising approach for achieving this goal. While the idea that extensive ‘training’ on computerized tasks will improve general cognitive functioning is appealing, the evidence to support this remains contentious. This is, in part, because of poor criteria for selecting training tasks and outcome measures resulting in inconsistent definitions of what constitutes transferable improvement to cognition. The current study used a targeted training approach to investigate whether training on two different, but related, working memory tasks (across two experiments, with 72 participants) produced transferable benefits to similar (quantified based on cognitive and neural profiles) untrained test tasks. Despite significant improvement on both training tasks, participants did not improve on either test task. In fact, performance on the test tasks after training were nearly identical to a passive control group. These results indicate that, despite maximizing the likelihood of producing transferable benefits, brain training does not generalize, even to very similar tasks. Our study calls into question the benefit of cognitive training beyond practice effects, and provides a new framework for future investigations into the efficacy of brain training.

Rediscovering ancient greek music.

I want to point to a fascinating article by Armand D’Angour at Oxford University, on efforts to reconstruct what music sounded like in ancient Greece. The work is also described in this YouTube video:

Controlling drones with a body-machine interface.

On first glance this article creeped me out, because when control of drones at a distance is mentioned I think of the drones used to bomb ISIS or Al Quaeda cells controlled by operators in Tampa, FL. However, more benign or typical applications include deployments in environments where it is not desirable or possible to send a human operator, such as nuclear plants, scenes of natural hazards, or more generally in search and rescue missions. Also, the use of teleoperated systems can augment human dexterity and precision in fields such as minimally invasive surgery or microfabrication.

Miehlbradt et al. suggest an alternative to current control interfaces (frequently employing joysticks) that that require intensive practice. They have developed an intuitive gesture based interface for real and simulated drones. They recorded the upper-body kinematics and muscle activities during the generation of movements that would imitate the behavior of a flying drone. After identifying two main interaction strategies used by the participants, they assessed the capacity of potential users to actively steer the path of a virtual drone employing these two strategies. Eventually, they evaluated the transferability of the skills acquired during simulation training to the control of a real drone. Their abstract, and a video:

The accurate teleoperation of robotic devices requires simple, yet intuitive and reliable control interfaces. However, current human–machine interfaces (HMIs) often fail to fulfill these characteristics, leading to systems requiring an intensive practice to reach a sufficient operation expertise. Here, we present a systematic methodology to identify the spontaneous gesture-based interaction strategies of naive individuals with a distant device, and to exploit this information to develop a data-driven body–machine interface (BoMI) to efficiently control this device. We applied this approach to the specific case of drone steering and derived a simple control method relying on upper-body motion. The identified BoMI allowed participants with no prior experience to rapidly master the control of both simulated and real drones, outperforming joystick users, and comparing with the control ability reached by participants using the bird-like flight simulator Birdly.

No gender differences in early math cognition.

Kersey et al. have examined data from more than 500 children ranging in age from 6 months to 8 years across several tests of numerosity, counting, and elementary mathematics concepts. They found no differences in mathematical performance between boys and girls in any of the ages tested, suggesting that gender differences in STEM representation are unlikely to be due to intrinsic differences in cognitive ability.

Recent public discussions have suggested that the under-representation of women in science and mathematics careers can be traced back to intrinsic differences in aptitude. However, true gender differences are difficult to assess because sociocultural influences enter at an early point in childhood. If these claims of intrinsic differences are true, then gender differences in quantitative and mathematical abilities should emerge early in human development. We examined cross-sectional gender differences in mathematical cognition from over 500 children aged 6 months to 8 years by compiling data from five published studies with unpublished data from longitudinal records. We targeted three key milestones of numerical development: numerosity perception, culturally trained counting, and formal and informal elementary mathematics concepts. In addition to testing for statistical differences between boys’ and girls’ mean performance and variability, we also tested for statistical equivalence between boys’ and girls’ performance. Across all stages of numerical development, analyses consistently revealed that boys and girls do not differ in early quantitative and mathematical ability. These findings indicate that boys and girls are equally equipped to reason about mathematics during early childhood.

A ecosystem of podcast bros who want to optimize your life.

I'm not a podcast or video kind of person, being too impatient to listen to or watch material that I can absorb more rapidly by reading about it. So, this piece by Molly Worthen describing a whole ecosystem of wellness gurus, a network of podcasters centered on Austin Texas and Southern California, was a revelation for me. (Note: this past November I did a post on an Austin based wellness project.) From her article:

...over the past few years the podcasters have become a significant cultural phenomenon, spiritual entrepreneurs who are filling the gap left as traditional religious organizations erode and modernity frays our face-to-face connections with communities and institutions...By my count, there are at least two dozen members of this podcast ecosystem...Several of these podcasters say they reach millions of listeners each month. In 2016, Joe Rogan put his figure “in the neighborhood of 30 million downloads per month”; his show is ranked second on the iTunes podcast chart, right behind Oprah.

In this secularized age of lonely seekers scrolling social media feeds, they have cultivated a spiritual community. They offer theologies and daily rituals of self-actualization, an appealing alternative to the rhetoric of victimhood and resentment that permeates both the right and the left...All this continues a long American tradition of self-help and creative, market-minded spirituality. The 19th century brimmed with gurus ready to guide you to other dimensions and prophets of the path from rags to riches.

Humans seem to be wired to seek salvation; even if polls suggest that more and more Americans reject traditional notions of God and skip church, it’s appealing to think that the latest lifestyle trend could be your path to existential bliss. The podcasters urge their listeners to experiment with fitness routines, diets, non-Western medicine, meditation and other “biohacks” to think more clearly, sleep more soundly and achieve professional success — and to quit blaming other people or bad luck for their problems.

Underlying this taste for experimentation is a deeper interest in evolutionary biology and psychology: the genes that, some experts believe, leave us programmed for a brutal, tribal, even pre-human past despite the creature comforts of the present...Evolutionary psychology is the secular answer to the doctrine of original sin: a primordial explanation for the anxieties that haunt us even if we have a decent job and a functional family...This is the podcast bro ethos: Ditch your ideologically charged identity. Accept your evolutionary programming. Take responsibility for mastering it, and find a cosmic purpose...Many have a strong interest in spirituality, and see practices like Buddhist meditation or consuming hallucinogenic “plant medicine” as not just a way to improve daily performance, but a path to something deeper.

The common thread linking the podcasters’ interest in evolutionary psychology and their metaphysical dabbling is the quest to transcend the ego, and to overcome the idea that we are personally aggrieved by enemies wholly unlike ourselves. This means mistrusting ideology and identitarian politics...having a one-world tribe, a tribe of human beings, period, is really what’s going to heal us for our next stage of life as a species on this planet.

Is this a postmodern monastic order, passing on breakfast and shivering in the shower while pondering the next step in mastering the ego? These podcasters lead one of the largest quasi-spiritual self-help “denominations” in the United States. It is a far-flung virtual community that gives people solace, a regimen and a sense of like-mindedness at a time when churches and other old-fashioned institutions simultaneously seem to ask too much, yet also fail to provide many people with whatever they’re looking for. The podcasters’ rejection of culture-wars partisanship resonates at a time when many Americans have stopped participating in politics (every listener I spoke to avoids political media the way they avoid, well, non-kale smoothies).

Yet podcasts are not churches. They are not political parties. They don’t patch over the existential void so much as reveal how avidly we yearn to fill it...The podcasters may offer a lesson to politicians and activists: to build a following, find a way to provide the sense of affiliation, daily rhythm and ultimate purpose that humans crave. Slogans of victimhood and grievance may rile up the base. But most people yearn, instead, for a sense of belonging and a path to mastery — even if it starts with a cold shower.

Our weaponized social media

I pass on a few clips from a sobering NYTimes article by Kara Swisher, who quotes from a recent Facebook post:

We face determined, well-funded adversaries who will never give up and are constantly changing tactics. It’s an arms race and we need to constantly improve too.

Continuing,

Facebook, as well as Twitter and Google’s YouTube, have become the digital arms dealers of the modern age...by weaponizing pretty much everything that could be weaponized. They have mutated human communication, so that connecting people has too often become about pitting them against one another, and turbocharged that discord to an unprecedented and damaging volume...They have weaponized social media. They have weaponized the First Amendment. They have weaponized civic discourse. And they have weaponized, most of all, politics.

Swisher's concluding paragraphs:

“I mean, my emotion is feeling a deep sense of responsibility to try to fix the problem,” said Mr. Zuckerberg. “In running a company, if you want to be innovative and advance things forward, I think you have to be willing to get some things wrong. But I don’t think it is acceptable to get the same things wrong over and over again.”

It was a classic Silicon Valley engineer’s roll-up-your-sleeves answer, which leaves many cold when it comes to, say, the manipulation of democracy. Fending off bad actors like the Russians has been and will be increasingly expensive; it may even be impossible. But Facebook could have done much more than it did, and it certainly needs to do more than it’s doing.

Mr. Zuckerberg is now trying to fend off talk in Washington of regulating his company like the thing he once told me it was: a utility. He has also spent the last month meeting over dinners with a range of academic experts on free speech, propaganda and more to try to understand where to go from here.

Call it the education of Mark Zuckerberg and Silicon Valley, but on the world’s dime. How much that has — and will — cost is probably immeasurable.

How pupil mimicry promotes trust.

Prochazkova et al. show that pupil mimicry promotes trust through our theory of mind brain network:

Significance

Trusting others is central for cooperative endeavors to succeed. To decide whether to trust or not, people generally make eye contact. As pupils of interaction partners align, mimicking pupil size helps them to make well-informed trust decisions. How the brain integrates information from the partner and from their own bodily feedback to make such decisions was unknown because previous research investigated these processes separately. Herein, we take a multimethod approach and demonstrate that pupil mimicry is regulated by the theory-of-mind network, and informs decisions of trust by activating the precuneus. This evolutionary ancient neurophysiological mechanism that is active in human adults, infants, and chimpanzees promotes affiliation, bonding, and trust through mimicry.

Abstract

The human eye can provide powerful insights into the emotions and intentions of others; however, how pupillary changes influence observers’ behavior remains largely unknown. The present fMRI–pupillometry study revealed that when the pupils of interacting partners synchronously dilate, trust is promoted, which suggests that pupil mimicry affiliates people. Here we provide evidence that pupil mimicry modulates trust decisions through the activation of the theory-of-mind network (precuneus, temporo-parietal junction, superior temporal sulcus, and medial prefrontal cortex). This network was recruited during pupil-dilation mimicry compared with interactions without mimicry or compared with pupil-constriction mimicry. Furthermore, the level of theory-of-mind engagement was proportional to individual’s susceptibility to pupil-dilation mimicry. These data reveal a fundamental mechanism by which an individual’s pupils trigger neurophysiological responses within an observer: when interacting partners synchronously dilate their pupils, humans come to feel reflections of the inner states of others, which fosters trust formation.

Brain regions involved in compensating for lost body parts.

From Striem-Amit et al.:

Significance

What determines the role of brain regions and their plasticity when typical inputs or experience is not provided? To what extent can extreme compensatory use affect brain organization? We tested the reorganization of primary and association sensorimotor cortex hand-selective areas in people born without hands, who use their feet for everyday tasks. We found that their primary sensorimotor hand area is preferentially activated for nearby body parts that cannot serve as effectors. In contrast, foot-selective compensatory plasticity was found in the association cortex, in an area typically involved in manual tool use. This shows limitations of compensatory plasticity and experience in modifying brain organization of early topographical cortex, as compared with association cortices where function-based organization is the driving factor.

Abstract

What forces direct brain organization and its plasticity? When brain regions are deprived of their input, which regions reorganize based on compensation for the disability and experience, and which regions show topographically constrained plasticity? People born without hands activate their primary sensorimotor hand region while moving body parts used to compensate for this disability (e.g., their feet). This was taken to suggest a neural organization based on functions, such as performing manual-like dexterous actions, rather than on body parts, in primary sensorimotor cortex. We tested the selectivity for the compensatory body parts in the primary and association sensorimotor cortex of people born without hands (dysplasic individuals). Despite clear compensatory foot use, the primary sensorimotor hand area in the dysplasic subjects showed preference for adjacent body parts that are not compensatorily used as effectors. This suggests that function-based organization, proposed for congenital blindness and deafness, does not apply to the primary sensorimotor cortex deprivation in dysplasia. These findings stress the roles of neuroanatomical constraints like topographical proximity and connectivity in determining the functional development of primary cortex even in extreme, congenital deprivation. In contrast, increased and selective foot movement preference was found in dysplasics’ association cortex in the inferior parietal lobule. This suggests that the typical motor selectivity of this region for manual actions may correspond to high-level action representations that are effector-invariant. These findings reveal limitations to compensatory plasticity and experience in modifying brain organization of early topographical cortex compared with association cortices driven by function-based organization.

Residential isolation of disadvantaged groups is not mitigated by extensive urban mobility.

Wang et al. offer yet another approach to observing the intractability of racial segregation in large cities:

Significance

Living in disadvantaged neighborhoods is widely assumed to undermine life chances because residents are isolated from neighborhoods with greater resources. Yet, residential isolation may be mitigated by individuals spending much of their everyday lives outside their home neighborhoods, a possibility that has been difficult to assess on a large scale. Using new methods to analyze urban mobility in the 50 largest American cities, we find that residents of primarily black and Hispanic neighborhoods—whether poor or not—are far less exposed to either nonpoor or white middle-class neighborhoods than residents of primarily white neighborhoods. Although residents of disadvantaged neighborhoods regularly travel as far and to as many different neighborhoods as those from advantaged neighborhoods, their relative isolation and segregation persist.

Abstract

Influential research on the negative effects of living in a disadvantaged neighborhood assumes that its residents are socially isolated from nonpoor or “mainstream” neighborhoods, but the extent and nature of such isolation remain in question. We develop a test of neighborhood isolation that improves on static measures derived from commonly used census reports by leveraging fine-grained dynamic data on the everyday movement of residents in America’s 50 largest cities. We analyze 650 million geocoded Twitter messages to estimate the home locations and travel patterns of almost 400,000 residents over 18 mo. We find surprisingly high consistency across neighborhoods of different race and income characteristics in the average travel distance (radius) and number of neighborhoods traveled to (spread) in the metropolitan region; however, we uncover notable differences in the composition of the neighborhoods visited. Residents of primarily black and Hispanic neighborhoods—whether poor or not—are far less exposed to either nonpoor or white middle-class neighborhoods than residents of primarily white neighborhoods. These large racial differences are notable given recent declines in segregation and the increasing diversity of American cities. We also find that white poor neighborhoods are substantially isolated from nonpoor white neighborhoods. The results suggest that even though residents of disadvantaged neighborhoods travel far and wide, their relative isolation and segregation persist.

Chimps can psych out humans

Interesting work from Eckert et al. shows that chimps can use mental state information revealed by experimenters' biases in selecting food items.

Great apes have been shown to be intuitive statisticians: they can use proportional information within a population to make intuitive probability judgments about randomly drawn samples [unpublished data]. Humans, from early infancy onward, functionally integrate intuitive statistics with other cognitive domains to judge the randomness of an event. To date, nothing is known about such cross-domain integration in any nonhuman animal, leaving uncertainty about the origins of human statistical abilities. We investigated whether chimpanzees take into account information about psychological states of experimenters (their biases and visual access) when drawing statistical inferences. We tested 21 sanctuary-living chimpanzees in a previously established paradigm that required subjects to infer which of two mixed populations of preferred and non-preferred food items was more likely to lead to a desired outcome for the subject. In a series of three experiments, we found that chimpanzees chose based on proportional information alone when they had no information about experimenters’ preferences and (to a lesser extent) when experimenters had biases for certain food types but drew blindly. By contrast, when biased experimenters had visual access, subjects ignored statistical information and instead chose based on experimenters’ biases. Lastly, chimpanzees intuitively used a violation of statistical likelihoods as indication for biased sampling. Our results suggest that chimpanzees have a random sampling assumption that can be overridden under the appropriate circumstances and that they are able to use mental state information to judge whether this is necessary. This provides further evidence for a shared statistical inference mechanism in apes and humans.

Enhanced brain activity associated with highly superior memory.

Santangelo et al. show that people with superior memory have enhanced connectivity of their prefrontal cortex with their hippocampus and temporoparietal junction:

Significance

Recent research has identified human subjects who have highly superior autobiographical memory (HSAM). Here, we investigated, using fMRI, the neural activation induced by retrieval of autobiographical memories (AMs) and semantic memories (SMs) in subjects with HSAM and control subjects. While their brains were being scanned, subjects had to retrieve AMs as well as SMs (e.g., examples of animals). The subjects with HSAM displayed a superior ability to retrieve details of AMs, supported by enhanced activation of several brain regions, including the medial prefrontal cortex and temporoparietal junction, as well as increased connectivity of the prefrontal cortex with the hippocampus, a region well known to be involved in memory representation. These findings suggest that activation of these systems may play a critical role in enabling HSAM.

Abstract

Brain systems underlying human memory function have been classically investigated studying patients with selective memory impairments. The discovery of rare individuals who have highly superior autobiographical memory (HSAM) provides, instead, an opportunity to investigate the brain systems underlying enhanced memory. Here, we carried out an fMRI investigation of a group of subjects identified as having HSAM. During fMRI scanning, eight subjects with HSAM and 21 control subjects were asked to retrieve autobiographical memories (AMs) as well as non-AMs (e.g., examples of animals). Subjects were instructed to signal the “access” to an AM by a key press and to continue “reliving” it immediately after. Compared with controls, individuals with HSAM provided a richer AM recollection and were faster in accessing AMs. The access to AMs was associated with enhanced prefrontal/hippocampal functional connectivity. AM access also induced increased activity in the left temporoparietal junction and enhanced functional coupling with sensory cortices in subjects with HSAM compared with controls. In contrast, subjects with HSAM did not differ from controls in functional activity during the reliving phase. These findings, based on fMRI assessment, provide evidence of interaction of brain systems engaged in memory retrieval and suggest that enhanced activity of these systems is selectively involved in enabling more efficient access to past experiences in HSAM.

Are things getting better or worse?

In a recent New Yorker article Joshua Rothman discusses debate over assessing the state of the world, with major emphasis on Pinker book "Enlightenment Now", which was the subject of a series of MindBlog posts March 1 - March 12 of this year. Things like "Progressophobia" on the part of intellectuals, people seeing the past through rose colored glasses, and media emphasizing momentary crises over long term trends lead most people to think that the world is getting worse rather than better, which, Pinker says, is "wrong wrong, flat-earth wrong."

Rothman's brief reviews of a number of other books debating progress and optimism versus pessimism about the future make his article well worth reading. I'll pass on the end of the article (note especially the last paragraph), which points to a book by Hans Rosling:

In “Factfulness: Ten Reasons We’re Wrong About the World—and Why Things Are Better Than You Think,” the Swedish global-health statistician Hans Rosling, who wrote the book with his son and daughter-in-law, tries to find such a picture. Most depictions of the world, Rosling thinks, are either too optimistic or too pessimistic; if they don’t succumb to despair, they seem to look too quickly away from suffering. Rosling adopts a mantra—“Bad and better”—to avoid these extremes. “Think of the world as a premature baby in an incubator,” he suggests:

The baby’s health status is extremely bad, and her breathing, heart rate, and other important signs are tracked constantly so that changes for better or worse can quickly be seen. After a week, she is getting a lot better. On all the main measures, she is improving, but she still has to stay in the incubator because her health is still critical. Does it make sense to say that the infant’s situation is improving? Yes. Absolutely. Does it make sense to say it is bad? Yes, absolutely. Does saying “things are improving” imply that everything is fine, and we should all relax and not worry? No, not at all. Is it helpful to have to choose between bad and improving? Definitely not. It’s both. It’s both bad and better. Better, and bad, at the same time. . . . That is how we must think about the current state of the world.

Rosling’s image captures many of the perplexities of our collective situation. We desperately want the baby to survive. We also know that survival doesn’t guarantee happiness. The baby is struggling, and suffering, and will continue to do so; as a result, we’re more likely to be happy for her than she is to be happy for herself. (Pinker, similarly, is happier for us than we are.) It’s possible, moreover, that she’ll be saved only temporarily. No one is ever truly out of the woods.

In the meantime, the baby’s survival depends on the act of diagnosis. Until her ailments are identified, they can’t be cured. Problems and progress are inextricable, and the history of improvement is also the history of problem-discovery. Diagnosis, of course, is an art in itself; it’s possible to misunderstand problems, or to overstate them, and, in doing so, to make them worse. But a world in which no one complained—in which we only celebrated how good we have it—would be a world that never improved. The spirit of progress is also the spirit of discontent.

Piano training enhances speech perception.

Fascinating work from an international collaboration of Desimone at M.I.T., Nan at Beijing Normal Univ., and others:

Significance

Musical training is beneficial to speech processing, but this transfer’s underlying brain mechanisms are unclear. Using pseudorandomized group assignments with 74 4- to 5-year-old Mandarin-speaking children, we showed that, relative to an active control group which underwent reading training and a no-contact control group, piano training uniquely enhanced cortical responses to pitch changes in music and speech (as lexical tones). These neural enhancements further generalized to early literacy skills: Compared with the controls, the piano-training group also improved behaviorally in auditory word discrimination, which was correlated with their enhanced neural sensitivities to musical pitch changes. Piano training thus improves children’s common sound processing, facilitating certain aspects of language development as much as, if not more than, reading instruction.

Abstract

Musical training confers advantages in speech-sound processing, which could play an important role in early childhood education. To understand the mechanisms of this effect, we used event-related potential and behavioral measures in a longitudinal design. Seventy-four Mandarin-speaking children aged 4–5 y old were pseudorandomly assigned to piano training, reading training, or a no-contact control group. Six months of piano training improved behavioral auditory word discrimination in general as well as word discrimination based on vowels compared with the controls. The reading group yielded similar trends. However, the piano group demonstrated unique advantages over the reading and control groups in consonant-based word discrimination and in enhanced positive mismatch responses (pMMRs) to lexical tone and musical pitch changes. The improved word discrimination based on consonants correlated with the enhancements in musical pitch pMMRs among the children in the piano group. In contrast, all three groups improved equally on general cognitive measures, including tests of IQ, working memory, and attention. The results suggest strengthened common sound processing across domains as an important mechanism underlying the benefits of musical training on language processing. In addition, although we failed to find far-transfer effects of musical training to general cognition, the near-transfer effects to speech perception establish the potential for musical training to help children improve their language skills. Piano training was not inferior to reading training on direct tests of language function, and it even seemed superior to reading training in enhancing consonant discrimination.

Mechanism of white matter changes induced by meditation?

Posner and collaborators, who previously have shown changes in brain white matter induced by meditation, suggest a possible mechanism, using a mouse model.

Meditation has been shown to modify brain connections. However, the cellular mechanisms by which this occurs are not known. We hypothesized that changes in white matter found following meditation may be due to increased rhythmicity observed in frontal areas in the cortex. The current study in mice tested this directly by rhythmically stimulating cells in the frontal midline. We found that such stimulation caused an increase in connectivity due to changes in the axons in the corpus callosum, which transmit impulses to and from the frontal midline. This work provides a plausible but not proven mechanism through which a mental activity such as meditation can improve brain connectivity.

The neuroscience of mindfulness meditation

I completely missed this review article by Posner and colleagues when it appeared, and am grateful for Bäumli's mention of it in her recent brief essay, which gives this link for downloading it. It has a mind numbing amount of information on research into the brain correlates of meditative practice and competence, summary tables, references, graphics. In this post I'm passing passing on the summary of key points and one graphic:

Key points

It is proposed that the mechanism through which mindfulness meditation exerts its effects is a process of enhanced self-regulation, including attention control, emotion regulation and self-awareness.

Research on mindfulness meditation faces a number of important challenges in study design that limit the interpretation of existing studies.

A number of changes in brain structure have been related to mindfulness meditation.

Mindfulness practice enhances attention. The anterior cingulate cortex is the region associated with attention in which changes in activity and/or structure in response to mindfulness meditation are most consistently reported.

Mindfulness practice improves emotion regulation and reduces stress. Fronto-limbic networks involved in these processes show various patterns of engagement by mindfulness meditation.

Meditation practice has the potential to affect self-referential processing and improve present-moment awareness. The default mode networks — including the midline prefrontal cortex and posterior cingulate cortex, which support self-awareness — could be altered following mindfulness training.

Mindfulness meditation has potential for the treatment of clinical disorders and might facilitate the cultivation of a healthy mind and increased well-being.

Future research into mindfulness meditation should use randomized and actively controlled longitudinal studies with large sample sizes to validate previous findings.

The effects of mindfulness practice on neural structure and function need to be linked to behavioural performance, such as cognitive, affective and social functioning, in future research.

The complex mental state of mindfulness is likely to be supported by the large-scale brain networks; future work should take this into account rather than being restricted to activations in single brain areas.

Legend - Schematic view of some of the brain regions involved in attention control (the anterior cingulate cortex and the striatum), emotion regulation (multiple prefrontal regions, limbic regions and the striatum) and self-awareness (the insula, medial prefrontal cortex and posterior cingulate cortex and precuneus).

When persistence doesn't pay - the sunk cost bias.

Sweis et al. show that sensitivity to time invested in pursuit of a reward occurs similarly in mice, rats, and humans. All three display a resistance to giving up their pursuit of a reward in a foraging context, but only after they have made the decision to pursue the reward. They suggest that there are two independent valuation processes, one assessing whether to accept an offer and the other — the one that is susceptible to sunk costs — assessing whether to continue investing in the choice. Their abstract:

Sunk costs are irrecoverable investments that should not influence decisions, because decisions should be made on the basis of expected future consequences. Both human and nonhuman animals can show sensitivity to sunk costs, but reports from across species are inconsistent. In a temporal context, a sensitivity to sunk costs arises when an individual resists ending an activity, even if it seems unproductive, because of the time already invested. In two parallel foraging tasks that we designed, we found that mice, rats, and humans show similar sensitivities to sunk costs in their decision-making. Unexpectedly, sensitivity to time invested accrued only after an initial decision had been made. These findings suggest that sensitivity to temporal sunk costs lies in a vulnerability distinct from deliberation processes and that this distinction is present across species.

Declining mental health among disadvantaged Americans.

Cherlin summarizes work by Goldman et al. that demonstrates "a troubling portrait of declining psychological health among non-Hispanic whites in mid- and later-life between the mid-1990s and the early 2010s... Equally troubling is the concentration of these declines among individuals with lower SES (socioeconomic status...life satisfaction declined for people at the 10th, 25th, and 50th percentiles of SES, remained constant for people at the 75th percentile, and increased for people at the 90th percentile. To the list of widening inequalities in the United States, which center on economic inequality, we must now add inequality in psychological health.

The Goldman et al. Abstract:

Significance

In the past few years, references to the opioid epidemic, drug poisonings, and associated feelings of despair among Americans, primarily working-class whites, have flooded the media, and related patterns of mortality have been of increasing interest to social scientists. Yet, despite recurring references to distress or despair in journalistic accounts and academic studies, there has been little analysis of whether psychological health among American adults has worsened over the past two decades. Here, we use data from national samples of adults in the mid-1990s and early 2010s to demonstrate increasing distress and declining well-being that was concentrated among low-socioeconomic-status individuals but spanned the age range from young to older adults.

Abstract

Although there is little dispute about the impact of the US opioid epidemic on recent mortality, there is less consensus about whether trends reflect increasing despair among American adults. The issue is complicated by the absence of established scales or definitions of despair as well as a paucity of studies examining changes in psychological health, especially well-being, since the 1990s. We contribute evidence using two cross-sectional waves of the Midlife in the United States (MIDUS) study to assess changes in measures of psychological distress and well-being. These measures capture negative emotions such as sadness, hopelessness, and worthlessness, and positive emotions such as happiness, fulfillment, and life satisfaction. Most of the measures reveal increasing distress and decreasing well-being across the age span for those of low relative socioeconomic position, in contrast to little decline or modest improvement for persons of high relative position.

Therapy for NYTAD - read about citrus micro-jets!

What is NYTAD? My just made up acronym for “New York Times Anxiety Disorder” - what I have to resist during my daily glance through the endless list of NYT and WaPo articles on the awful human being who serves as our president. And then, unexpectedly, a point of light. A neat article about something else: the microjets of citrus oil you see when you squeeze the skin of an orange or lemon. It turns out that the layered construction of the citrus exocarp allows for the buildup of fluid pressure in citrus oil gland reservoirs and their subsequent explosive rupture . I'll pass on the abstract of the PNAS article to which it refers, which gives the interesting details, along with a video.

Significance

Here we show a unique, natural method for microscale jetting of fluid made possible by the tuning of material properties from which the jets emanate. The composite, layered construction of the citrus exocarp allows for the buildup of fluid pressure in citrus oil gland reservoirs and their subsequent explosive rupture. Citrus jetting has not been documented in literature, and its purpose is unknown. This method for microscale fluid dispersal requires no auxiliary equipment and may open avenues for new methods of medicine and chemical delivery. We show how jet kinematics are related to substrate properties and reservoir shape.

Abstract

The rupture of oil gland reservoirs housed near the outer surface of the citrus exocarp is a common experience to the discerning citrus consumer and bartenders the world over. These reservoirs often rupture outwardly in response to bending the peel, which compresses the soft material surrounding the reservoirs, the albedo, increasing fluid pressure in the reservoir. Ultimately, fluid pressure exceeds the failure strength of the outermost membrane, the flavedo. The ensuing high-velocity discharge of oil and exhaustive emptying of oil gland reservoirs creates a method for jetting small quantities of the aromatic oil. We compare this jetting behavior across five citrus hybrids through high-speed videography. The jetting oil undergoes an extreme acceleration to reach velocities in excess of 10 m/s. Through material characterization and finite element simulations, we rationalize the combination of tuned material properties and geometries enabling the internal reservoir pressures that produce explosive dispersal, finding the composite structure of the citrus peel is critical for microjet production.

Crows make mental templates.

Weintraub points to further studies from the University of Aukland School of Psychology on the extraordinary New Caledonian crows that have been shown to learn tool use. They also appear to use “mental template matching” - forming an image in their heads of tools they have seen used by others, and then copying them.

 

Perceptual and judgement creep.

Fascinating work by Gilbert and colleagues:

Why do some social problems seem so intractable? In a series of experiments, we show that people often respond to decreases in the prevalence of a stimulus by expanding their concept of it. When blue dots became rare, participants began to see purple dots as blue; when threatening faces became rare, participants began to see neutral faces as threatening; and when unethical requests became rare, participants began to see innocuous requests as unethical. This “prevalence-induced concept change” occurred even when participants were forewarned about it and even when they were instructed and paid to resist it. Social problems may seem intractable in part because reductions in their prevalence lead people to see more of them.

Authentic lies.

Hahl et al. suggest how a blatantly lying demagogue (guess who?) can be perceived as authentic:

We develop and test a theory to address a puzzling pattern that has been discussed widely since the 2016 U.S. presidential election and reproduced here in a post-election survey: how can a constituency of voters find a candidate “authentically appealing” (i.e., view him positively as authentic) even though he is a “lying demagogue” (someone who deliberately tells lies and appeals to non-normative private prejudices)? Key to the theory are two points: (1) “common-knowledge” lies may be understood as flagrant violations of the norm of truth-telling; and (2) when a political system is suffering from a “crisis of legitimacy” with respect to at least one political constituency, members of that constituency will be motivated to see a flagrant violator of established norms as an authentic champion of its interests. Two online vignette experiments on a simulated college election support our theory. These results demonstrate that mere partisanship is insufficient to explain sharp differences in how lying demagoguery is perceived, and that several oft-discussed factors—information access, culture, language, and gender—are not necessary for explaining such differences. Rather, for the lying demagogue to have authentic appeal, it is sufficient that one side of a social divide regards the political system as flawed or illegitimate.

Social media and the emergence of violence during protests.

The social media, and especially Twitter, are now integral to modern political behavior, with events online both reflecting and influencing actions offline. Mooijman et al. have used geolocated Twitter data to argue that moralization of protests leads to violent protests and increased support for violence.

In recent years, protesters in the United States have clashed violently with police and counter-protesters on numerous occasions. Despite widespread media attention, little scientific research has been devoted to understanding this rise in the number of violent protests. We propose that this phenomenon can be understood as a function of an individual’s moralization of a cause and the degree to which they believe others in their social network moralize that cause. Using data from the 2015 Baltimore protests, we show that not only did the degree of moral rhetoric used on social media increase on days with violent protests but also that the hourly frequency of morally relevant tweets predicted the future counts of arrest during protests, suggesting an association between moralization and protest violence. To better understand the structure of this association, we ran a series of controlled behavioural experiments demonstrating that people are more likely to endorse a violent protest for a given issue when they moralize the issue; however, this effect is moderated by the degree to which people believe others share their values. We discuss how online social networks may contribute to inflations of protest violence.