We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat. We found that chronic administration of fluoxetine reinstates ocular dominance plasticity in adulthood and promotes the recovery of visual functions in adult amblyopic animals, as tested electrophysiologically and behaviorally. These effects were accompanied by reduced intracortical inhibition and increased expression of brain-derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the reduction of intracortical inhibition promotes visual cortical plasticity in the adult. Our results suggest a potential clinical application for fluoxetine in amblyopia as well as new mechanisms for the therapeutic effects of antidepressants and for the pathophysiology of mood disorders.
Wednesday, April 23, 2008
An antidepressant enhances brain plasticity
The title of the article by Vetencourt et al. is "The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex. " [Fluoxetine hydrochloride, i.e. Prozac, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.] Here is their abstract: