Why we can't tell the truth about aging.

I've enjoyed reading the New Yorker essay by Arthur Krystal titled "Why we can't tell the truth about aging," which points to and discusses numerous recent (as well as a few ancient) books on aging. Here is a selection of rearranged small clips from the article.

Average life expectancy was indeed a sorry number for the greater part of history (for Americans born as late as 1900, it wasn’t even fifty), which may be one reason that people didn’t write books about aging: there weren’t enough old folks around to sample them. But now that more people on the planet are over sixty-five than under five, an army of readers stands waiting to learn what old age has in store.

Now that we’re living longer, we have the time to write books about living longe...The library on old age has grown so voluminous that the fifty million Americans over the age of sixty-five could spend the rest of their lives reading such books, even as lusty retirees and power-lifting septuagenarians turn out new ones.

Our senior years are evidently a time to celebrate ourselves and the wonderful things to come: travelling, volunteering, canoodling, acquiring new skills, and so on. No one, it seems, wants to disparage old age...we get cheerful tidings...chatty accounts meant to reassure us that getting old just means that we have to work harder at staying young...authors aren’t blind to the perils of aging; they just prefer to see the upside. All maintain that seniors are more comfortable in their own skins.

There is, of course, a chance that you may be happier at eighty than you were at twenty or forty, but you’re going to feel much worse. I know this because two recent books provide a sobering look at what happens to the human body as the years pile up. Elizabeth Blackburn and Elissa Epel’s “The Telomere Effect: Living Younger, Healthier, Longer” and Sue Armstrong’s “Borrowed Time: The Science of How and Why We Age” describe what is essentially a messy business.

Basically, most cells divide and replicate some fifty-plus times before becoming senescent. Not nearly as inactive as the name suggests, senescent cells contribute to chronic inflammation and interfere with protective collagens...The so-called epigenetic clock shows our DNA getting gummed up, age-related mitochondrial mutations reducing the cells’ ability to generate energy, and our immune system slowly growing less efficient. Bones weaken, eyes strain, hearts flag. Bladders empty too often, bowels not often enough, and toxic proteins build up in the brain to form the plaque and the spaghetti-like tangles that are associated with Alzheimer’s disease. Not surprisingly, sixty-eight per cent of Medicare beneficiaries today have multiple chronic conditions. Not a lot of grace, force, or fascination in that.

In short, the optimistic narrative of pro-aging writers doesn’t line up with the dark story told by the human body. But maybe that’s not the point. “There is only one solution if old age is not to be an absurd parody of our former life,” Simone de Beauvoir wrote in her expansive 1970 study “The Coming of Age,” “and that is to go on pursuing ends that give our existence a meaning—devotion to individuals, to groups, or to causes—social, political, intellectual, or creative work.”

One would, of course, like to approach old age with grace and fortitude, but old age makes it difficult. Those who feel that it’s a welcome respite from the passions, anxieties, and troubles of youth or middle age are either very lucky or toweringly reasonable. Why rail against the inevitable—what good will it do? None at all. Complaining is both pointless and unseemly. Existence itself may be pointless and unseemly.

We should all make peace with aging. And so my hat is off to Dr. Oliver Sacks, who chose to regard old age as “a time of leisure and freedom, freed from the factitious urgencies of earlier days, free to explore whatever I wish, and to bind the thoughts and feelings of a lifetime together.”

World wide movement of people into cities is degrading the human microbiome

From the Oct. 25 issue of Science Magazine:

Sonnenburg and Sonnenburg review how the shift of recent generations from rural, outdoor environments to urbanized and industrialized settings has profoundly affected our biology and health. The signals of change are seen most strikingly in the reduction of commensal microbial taxa and loss of their metabolic functions. The extirpation of human commensals is a result of bombardment by new chemicals, foodstuffs, sanitation, and medical practices. For most people, sanitation and readily available food have been beneficial, but have we now reached a tipping point? How do we “conserve” our beneficial symbionts and keep the pathogens at bay?

Here is their abstract:

The human body is an ecosystem that is home to a complex array of microbes known as the microbiome or microbiota. This ecosystem plays an important role in human health, but as a result of recent lifestyle changes occurring around the planet, whole populations are seeing a major shift in their gut microbiota. Measures meant to kill or limit exposure to pathogenic microbes, such as antibiotics and sanitation, combined with other factors such as processed food, have had unintended consequences for the human microbial ecosystem, including changes that may be difficult to reverse. Microbiota alteration and the accompanying loss of certain functional attributes might result in the microbial communities of people living in industrialized societies being suboptimal for human health. As macroecologists, conservationists, and climate scientists race to document, understand, predict, and delay global changes in our wider environment, microbiota scientists may benefit by using analogous approaches to study and protect our intimate microbial ecosystems.

How human breeding has changed dogs’ brains

Hecht et al. have identified brain networks in dogs related to behavioral specializations roughly corresponding to sight hunting, scent hunting, guarding, and companionship. Here is their detailed abstract:

Humans have bred different lineages of domestic dogs for different tasks such as hunting, herding, guarding, or companionship. These behavioral differences must be the result of underlying neural differences, but surprisingly, this topic has gone largely unexplored. The current study examined whether and how selective breeding by humans has altered the gross organization of the brain in dogs. We assessed regional volumetric variation in MRI studies of 62 male and female dogs of 33 breeds. Neuroanatomical variation is plainly visible across breeds. This variation is distributed nonrandomly across the brain. A whole-brain, data-driven independent components analysis established that specific regional subnetworks covary significantly with each other. Variation in these networks is not simply the result of variation in total brain size, total body size, or skull shape. Furthermore, the anatomy of these networks correlates significantly with different behavioral specialization(s) such as sight hunting, scent hunting, guarding, and companionship. Importantly, a phylogenetic analysis revealed that most change has occurred in the terminal branches of the dog phylogenetic tree, indicating strong, recent selection in individual breeds. Together, these results establish that brain anatomy varies significantly in dogs, likely due to human-applied selection for behavior.

A triple drug combination increases lifespan by 48%

In Drosophila flies, to be sure, but the nutrient sensing pathways that are the target of the drugs are common to all animals. Here is the abstract from open source article by Castillo-!uan et al.:

Increasing life expectancy is causing the prevalence of age-related diseases to rise, and there is an urgent need for new strategies to improve health at older ages. Reduced activity of insulin/insulin-like growth factor signaling (IIS) and mechanistic target of rapamycin (mTOR) nutrient-sensing signaling network can extend lifespan and improve health during aging in diverse organisms. However, the extensive feedback in this network and adverse side effects of inhibition imply that simultaneous targeting of specific effectors in the network may most effectively combat the effects of aging. We show that the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib, the mTOR complex 1 (mTORC1) inhibitor rapamycin, and the glycogen synthase kinase-3 (GSK-3) inhibitor lithium act additively to increase longevity in Drosophila. Remarkably, the triple drug combination increased lifespan by 48%. Furthermore, the combination of lithium with rapamycin cancelled the latter’s effects on lipid metabolism. In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health.

Skill development - the intelligence vs. practice debate reframed

Vaci et al. note that what is often overlooked in the nature vs. nurture debate is the fact that both factors interact with each other:

The relative importance of different factors in the development of human skills has been extensively discussed. Research on expertise indicates that focused practice may be the sole determinant of skill, while intelligence researchers underline the relative importance of abilities at even the highest level of skill. There is indeed a large body of research that acknowledges the role of both factors in skill development and retention. It is, however, unknown how intelligence and practice come together to enable the acquisition and retention of complex skills across the life span. Instead of focusing on the 2 factors, intelligence and practice, in isolation, here we look at their interplay throughout development. In a longitudinal study that tracked chess players throughout their careers, we show that both intelligence and practice positively affect the acquisition and retention of chess skill. Importantly, the nonlinear interaction between the 2 factors revealed that more intelligent individuals benefited more from practice. With the same amount of practice, they acquired chess skill more quickly than less intelligent players, reached a higher peak performance, and arrested decline in older age. Our research demonstrates the futility of scrutinizing the relative importance of highly intertwined factors in human development.

The miracle cure - just move

A summary from the editor of the British Medical Journal of work by Ekelund et. al.:

As miracle cures are hard to come by, any claims that a treatment is 100% safe and effective must always be viewed with intense scepticism. There is perhaps one exception. Physical activity has been called a miracle cure by no less a body than the Academy of Medical Sciences (http://bit.ly/2lTqDvc); and, like those who avail themselves of it, the supporting science grows stronger by the day. The BMJ recently published a systematic review showing a clear dose-response relation between physical activity and all cause mortality (doi:10.1136/bmj.l4570). The authors concluded that any level of activity is better than none, and more is better still, a message recently encapsulated in the updated guidelines from the UK’s chief medical officers (doi:10.1136/bmj.l5470).

The statement from the authors on their analysis of numerous studies:

We conducted a harmonised meta-analysis to examine the association between accelerometer measured physical activity and sedentary time and all cause mortality. Specifically, we examined the dose-response relations of total physical activity, different intensities of physical activity (light, low light, high light, moderate to vigorous, and vigorous) and sedentary time and all cause mortality.

Feeling grateful - a shortcut to virtuous behavior.

Psychologist David DeSteno, in an Aeon essay, summarizes his experiments suggesting that moving towards a more virtuous life might accomplished by simply cultivating gratitude, a more simple route than through deep deliberation on noble qualities such as honesty and generosity. Subjects were asked to report the results of a coin toss in which heads yielded a larger financial reward than tails. The coins were rigged to always come up tails.

The percentage of cheaters fell by half (from almost 49 per cent to 27 per cent) among those who had just recalled a time when they felt grateful, compared with those who described a time when they felt happy or no particular emotion at all.

They then did a second experiment that..

...had two key differences. First, the coin flip determined whether any given participant would have to complete an enjoyable 10-minute task or a difficult 45-minute one. Second, we led participants to believe that the next person to come would be assigned to complete whichever task remained.

In deciding to cheat by reporting that the virtual coin flip came up heads, people were giving themselves a much shorter and more enjoyable task, but in so doing, were also unfairly dooming another person to a more onerous task.

As one might imagine, the overall frequency of cheating was lower. Nonetheless, gratitude worked in the exact same way. Whereas 17 per cent of people cheated when feeling neutral or happy, only 2 per cent cheated when feeling grateful.

The empirical literature shows a similar influence of gratitude on other virtues. People feeling grateful are more likely to help others who request assistance, to divide their profits in a more egalitarian way, to be loyal even at cost to themselves, to be less materialistic, and even to exercise as opposed to loafing.

Five myths about aging.

I want to pass on a few clips from this piece by William Mair, who researches the biology of aging at Harvard:

MYTH NO. 1 Biological aging can't be slowed. The growing field of geroscience offers hope... that genetic alterations and drugs such as rapamycin can slow the rate at which animals age.

MYTH NO. 2 Live fast, die young. Recent work shows that regular exercise helps slow key signs of aging, boosting immune function and curbing mental decline. If anything, conserving our batteries as isolated couch potatoes ages us faster.

MYTH NO. 3 Antioxidants slow aging. Free radicals...have captured the public imagination as a source of old age with little scientific evidence. There is in fact more negative data than positive examples.

MYTH NO. 4 Fewer calories mean a longer life. In truth, we just don’t know that the benefit of strict diets lies solely in their calorie content. Increasingly, it seems that many of the positive effects of calorie restriction on aging may be unrelated to caloric intake. Hungry animals and people tend to eat faster, and as a result spend more of their day eating nothing. These extended periods of abstinence are enough to slow aging in mice, whether overall calorie intake is reduced or not. The science uncoupling the effects of fasting and calorie restriction on aging is in its infancy.

MYTH NO. 5 Short telomeres explain aging. Aging is not caused by one event, however, as compelling as fraying telomeres may be. Some of our cells do not divide at all, and they age without shortened telomeres. Many animals have telomeres much longer than ours, yet they age faster than we do. Shortening telomeres may even be useful, protecting against unchecked cell division, which is a hallmark of cancer.

The Metamorphosis of the Western Soul

I want to point to an article by Will Storr "The Metamorphosis of the Western Soul" that has been languishing for over a year in my list of references that might become the basis of a MindBlog post. Storr presents a nice distillation of the story of how Between 1965 and 1985, the Western self was transformed. Storr's basic point is that economic forces are the dominant reason for these changes.

We turned from anti-materialistic, stick-it-to-the-Man hippies into greed-is-good yuppies... While the origins of such changes cannot be reduced to a single source, I believe we can point to a dominant one: the economy. In the early 1980s, President Ronald Reagan and the British Prime Minister Margaret Thatcher rewrote the rules by which we had once lived. And that, with stunning rapidity, changed who we were.

Storr proceeds review the historical story of how citizens of the individualistic West and the collectivist East have developed fundamental cognitive differences - largely adaptations to different physical landscapes - in how they view the world through collectivist versus individualistic filters. But, there is plasticity:

Humans are born incomplete. The brain absorbs huge amounts of essential information throughout childhood and adolescence, which it uses to carry on building who we are. It’s as if the brain asks a single, vital question: Who do I have to be, in this place, to thrive? If it was a boastful hustler in ancient Greece and a humble team-player in ancient China, then who is it in the West today?

The answer is a neoliberal...After the economic chaos of the 1970s, it was decided that the United States and Britain had become too collective. Previous decades had seen the introduction of the New Deal, which included the Social Security Act, strict regulations on banking and business, and the rising power of the unions. This collectively tilted economy sired a collectively tilted people...For Mr. Reagan and Mrs. Thatcher, saving ourselves meant rediscovering our individualist roots.

They cut taxes and regulations; they battled unions; they shrunk the welfare state; they privatized assets and weakened the state’s safety nets. They pursued the neoliberal dream of globalization — one free market that covered the earth. As much of human life as possible was to become a competition of self versus self...In 1981, Margaret Thatcher said “Economics are the method: The object is to change the soul.” And that’s precisely what happened.

Before 2008, it felt as if neoliberalism was basically working for most people. But since the crash, millions have come to see the system as broken...We have seen the neoliberal Hillary Clinton falter and the antiglobalist Donald Trump triumph. Britain’s Brexit was secured by antiglobalist arguments....The perception of a broken, rigged economy has left us angry and increasingly tribal, which might explain this recent trend toward “us” over the narcissistic “me.”

If this is correct, it’s yet more evidence that who we are is powerfully influenced by where we are. Humans want to get along and get ahead and will become whoever they need to be in order to do so. In the 21st century, those rules are no longer set by our physical landscape. Today, the deep and enormously powerful controlling force is the economy.

Shape of your heart is determined by whether you run or sit.

Shave et al. show that endurance runners and farmers have larger, elongated left ventricles with thin walls (traits that help pump large volumes of blood for a long time) compared with football linemen, whose training emphasizes short, high-intensity exercise. Linemen, as well has sedentary people, have shorter, wider ventricles with thicker walls and are more prone to hypertensive heart disease. Their experiments used ultrasound imaging to examine the hearts of more than 160 adult men from four groups: long-distance runners, sedentary adults, highly trained football linemen, and the Tarahumara, Native American farmers renowned for their running ability.

Abstract

Chimpanzees and gorillas, when not inactive, engage primarily in short bursts of resistance physical activity (RPA), such as climbing and fighting, that creates pressure stress on the cardiovascular system. In contrast, to initially hunt and gather and later to farm, it is thought that preindustrial human survival was dependent on lifelong moderate-intensity endurance physical activity (EPA), which creates a cardiovascular volume stress. Although derived musculoskeletal and thermoregulatory adaptations for EPA in humans have been documented, it is unknown if selection acted similarly on the heart. To test this hypothesis, we compared left ventricular (LV) structure and function across semiwild sanctuary chimpanzees, gorillas, and a sample of humans exposed to markedly different physical activity patterns. We show the human LV possesses derived features that help augment cardiac output (CO) thereby enabling EPA. However, the human LV also demonstrates phenotypic plasticity and, hence, variability, across a wide range of habitual physical activity. We show that the human LV’s propensity to remodel differentially in response to chronic pressure or volume stimuli associated with intense RPA and EPA as well as physical inactivity represents an evolutionary trade-off with potential implications for contemporary cardiovascular health. Specifically, the human LV trades off pressure adaptations for volume capabilities and converges on a chimpanzee-like phenotype in response to physical inactivity or sustained pressure loading. Consequently, the derived LV and lifelong low blood pressure (BP) appear to be partly sustained by regular moderate-intensity EPA whose decline in postindustrial societies likely contributes to the modern epidemic of hypertensive heart disease.

The default mode network represents esthetic appeal.

Vessel et al. note another role for the default mode network of our brain:

Significance

Despite being highly subjective, aesthetic experiences are powerful moments of interaction with one’s surroundings, shaping behavior, mood, beliefs, and even a sense of self. The default-mode network (DMN), which sits atop the cortical hierarchy and has been implicated in self-referential processing, is typically suppressed when a person engages with the external environment. Yet not only is the DMN surprisingly engaged when one finds a visual artwork aesthetically moving, here we present evidence that the DMN also represents aesthetic appeal in a manner that generalizes across visual aesthetic domains, such as artworks, landscapes, or architecture. This stands in contrast to ventral occipitotemporal cortex (VOT), which represents the content of what we see, but does not contain domain-general information about aesthetic appeal.

Abstract

Visual aesthetic evaluations, which impact decision-making and well-being, recruit the ventral visual pathway, subcortical reward circuitry, and parts of the medial prefrontal cortex overlapping with the default-mode network (DMN). However, it is unknown whether these networks represent aesthetic appeal in a domain-general fashion, independent of domain-specific representations of stimulus content (artworks versus architecture or natural landscapes). Using a classification approach, we tested whether the DMN or ventral occipitotemporal cortex (VOT) contains a domain-general representation of aesthetic appeal. Classifiers were trained on multivoxel functional MRI response patterns collected while observers made aesthetic judgments about images from one aesthetic domain. Classifier performance (high vs. low aesthetic appeal) was then tested on response patterns from held-out trials from the same domain to derive a measure of domain-specific coding, or from a different domain to derive a measure of domain-general coding. Activity patterns in category-selective VOT contained a degree of domain-specific information about aesthetic appeal, but did not generalize across domains. Activity patterns from the DMN, however, were predictive of aesthetic appeal across domains. Importantly, the ability to predict aesthetic appeal varied systematically; predictions were better for observers who gave more extreme ratings to images subsequently labeled as “high” or “low.” These findings support a model of aesthetic appreciation whereby domain-specific representations of the content of visual experiences in VOT feed in to a “core” domain-general representation of visual aesthetic appeal in the DMN. Whole-brain “searchlight” analyses identified additional prefrontal regions containing information relevant for appreciation of cultural artifacts (artwork and architecture) but not landscapes.

Cross-national negativity bias in reacting to news

There seems to be a world-wide anxiety industry of media that find maximum profits in presenting mostly negative news - in a way similar to the drug companies that have reaped great profits from flooding distressed population areas with opioids. An interesting study in this area comes from Soroka et al., who provide more information on our human tendency to react more strongly to negative than positive information. (See also my post on Pinker's "Enlightenment Now" book that engages this topic):

What accounts for the prevalence of negative news content? One answer may lie in the tendency for humans to react more strongly to negative than positive information. “Negativity biases” in human cognition and behavior are well documented, but existing research is based on small Anglo-American samples and stimuli that are only tangentially related to our political world. This work accordingly reports results from a 17-country, 6-continent experimental study examining psychophysiological reactions to real video news content. Results offer the most comprehensive cross-national demonstration of negativity biases to date, but they also serve to highlight considerable individual-level variation in responsiveness to news content. Insofar as our results make clear the pervasiveness of negativity biases on average, they help account for the tendency for audience-seeking news around the world to be predominantly negative. Insofar as our results highlight individual-level variation, however, they highlight the potential for more positive content, and suggest that there may be reason to reconsider the conventional journalistic wisdom that “if it bleeds, it leads.”

An update on the science of ‘free will’

I want to point to an excellent article by Gholilpour in the Atlantic Magazine that describes a reinterpretation of experiments by Libet taken to suggest that our brains 'decide' to initiate a movement before our subjective awareness of intending to initiate that movement. A 'readiness potential' is observed about 500 msec before an action occurs, while a subject reports initiating that action about 150 msec before it occurs. Gholilpour points to work of Schurger and colleagues that suggests that the readiness potential is not the mark of a brain's brewing intention, but something much more circumstantial.

...Schurger and his colleagues ... proposed an explanation. Neuroscientists know that for people to make any type of decision, our neurons need to gather evidence for each option. The decision is reached when one group of neurons accumulates evidence past a certain threshold. Sometimes, this evidence comes from sensory information from the outside world: If you’re watching snow fall, your brain will weigh the number of falling snowflakes against the few caught in the wind, and quickly settle on the fact that the snow is moving downward.

Libet’s experiment, Schurger pointed out, provided its subjects with no such external cues. To decide when to tap their fingers, the participants simply acted whenever the moment struck them. Those spontaneous moments, Schurger reasoned, must have coincided with the haphazard ebb and flow of the participants’ brain activity. They would have been more likely to tap their fingers when their motor system happened to be closer to a threshold for movement initiation.

This would not imply, as Libet had thought, that people’s brains “decide” to move their fingers before they know it. Hardly. Rather, it would mean that the noisy activity in people’s brains sometimes happens to tip the scale if there’s nothing else to base a choice on, saving us from endless indecision when faced with an arbitrary task. The readiness potential would be the rising part of the brain fluctuations that tend to coincide with the decisions. This is a highly specific situation, not a general case for all, or even many, choices.

The name Schurger rang a bell with me, and so I did a MindBlog search, only to discover that I had reported Schurger's work in a 2016 post "A 50 year misunderstanding of how we decide to initiate action - our intuition is valid". I then proceeded to completely forget about it when I was preparing a subsequent 2019 lecture mentioning Libet's work. The conventional dogma that we are 'late to action' was apparently burned into my brain - most embarrassing. (I've now inserted the new perspective into four of my web lectures, dating as far back as 2012). The real clincher is...

In a new study under review for publication in the Proceedings of the National Academy of Sciences, Schurger and two Princeton researchers repeated a version of Libet’s experiment. To avoid unintentionally cherry-picking brain noise, they included a control condition in which people didn’t move at all. An artificial-intelligence classifier allowed them to find at what point brain activity in the two conditions diverged. If Libet was right, that should have happened at 500 milliseconds before the movement. But the algorithm couldn’t tell any difference until about only 150 milliseconds before the movement, the time people reported making decisions in Libet’s original experiment.

In other words, people’s subjective experience of a decision—what Libet’s study seemed to suggest was just an illusion—appeared to match the actual moment their brains showed them making a decision.

Gholilpour points out that this does not resolve the question of free will, it only deepens the question, which is the subject of an intensive collaboration between neuroscientists and philosophers, backed by $7 million from two private foundations, the John Templeton Foundation and the Fetzer Institute.

More critique of work linking loving kindness meditation and cellular again

In my Sept. 23 post, "Loving kindness meditation slows cellular aging?", I gave a few of the reasons that the article triggered my bullshit detector. A email from Harris Friedman, Univ. of Florida, has pointed me to their more extended critique in a letter to the editor of Psychoneuroendocrinology, which I pass on in a slightly truncated version:

Extraordinary claims require compelling evidence: Concerns about “loving-kindness meditation slows biological aging in novices”

The recent paper by Le Nguyen et al. (2019) makes the extra- ordinary claim that loving-kindness meditation (LKM) slows biological aging. Unfortunately, its headline-grabbing title lacks compelling evidence. This paper shows telomere length (TL) decreased considerably in a control group over a very short time period, as compared to a LKM group, while a mindfulness meditation (MM) group was somewhere in between. From this difference, the paper argues that LKM slows biological aging, which is quite a logical leap. Clearly LKM had nothing to do with the extent of TL shrinkage in the control group, and why the control group’s TL decreased so much is ignored in the paper. More generally, there are many problems with using TL as a proxy for biological aging. Even if this paper’s basic logic is accepted, there are many problems with how the paper’s data are handled.1 The most important problem is the absence of any analyses that provides a direct and straightforward examination of pre-post TL as a function of experimental condition. Consequently, we ran a 2×3 mixed factorial ANOVA using TL measured across two times (pre and post) compared across three conditions (control, MM, and LKM) with the paper’s data. Although a significant repeated measures main effect was found, the interaction with experimental condition was non-sig- nificant. One-way ANOVAs examining pre-, post-, and change/differ- ence TL variables as a function of condition also produced non-sig nificant results. Looking at the data using other statistical approaches, however, did show some pattern of mixed results that trend, although most are non-significant, in the direction of the LKM group having less TL shortening compared to the other groups. Regardless of analysis, effect sizes were consistently meager.

In addition, there are several serious confounds compromising any valid comparison among the groups. For example, the data show that six in the control group engaged in some meditation, and one even reported meditating 16 days during the study’s short time-span. This hardly constitutes an adequate control group for a meditation study. Also, the LKM group spent considerably more time meditating than the MM group, so these did not differ only in meditation type. We are unable to address many other problems with this paper due to this journal’s length restrictions in a letter to the editor. We simply conclude that this paper’s extraordinary claim does not have the compelling evidence to back it up, and we urge not making extraordinary claims without such evidence. 

Harris L. Friedman - University of Florida, United States
Douglas A. MacDonald - University of Detroit Mercy, United States
Nicholas J.L. Brown-  University of Groningen, the Netherlands
James C. Coyne University of Pennsylvania, United States

Psilocybin + Mindfulness Meditation change brain connectivity - lasting positive effects

Dolan points to work by Smigielski et al.:

Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergistic effects on neurobiology are unknown. Accordingly, we conducted a randomized, double-blind, placebo-controlled study with 38 participants following a single administration of the psychedelic psilocybin (315 μg/kg p.o.) during a 5-day mindfulness retreat. Brain dynamics were quantified directly pre- and post-intervention by functional magnetic resonance imaging during the resting state and two meditation forms. The analysis of functional connectivity identified psilocybin-related and mental state–dependent alterations in self-referential processing regions of the default mode network (DMN). Notably, decoupling of medial prefrontal and posterior cingulate cortices, which is thought to mediate sense of self, was associated with the subjective ego dissolution effect during the psilocybin-assisted mindfulness session. The extent of ego dissolution and brain connectivity predicted positive changes in psycho-social functioning of participants 4 months later. Psilocybin, combined with meditation, facilitated neurodynamic modulations in self-referential networks, subserving the process of meditation by acting along the anterior–posterior DMN connection. The study highlights the link between altered self-experience and subsequent behavioral changes. Understanding how interventions facilitate transformative experiences may open novel therapeutic perspectives. Insights into the biology of discrete mental states foster our understanding of non-ordinary forms of human self-consciousness and their concomitant brain substrate.

Mindfulness doesn't reduce impulsive behavior.

Korponay, Davidson and colleagues present results of a study that were contrary to their expectation that the practice of mindfulness meditation would correlate with a reduction in impulsive behaviors (like having that second dish of ice cream). What they found is that neither short-term nor long-term meditation appears to be effective for reducing impulsivity that is not related to attentional difficulties, but rather is a function of motor control and planning capacities. Here is their detailed abstract:

Interest has grown in using mindfulness meditation to treat conditions featuring excessive impulsivity. However, while prior studies find that mindfulness practice can improve attention, it remains unclear whether it improves other cognitive faculties whose deficiency can contribute to impulsivity. Here, an eight-week mindfulness intervention did not reduce impulsivity on the go/no-go task or Barratt Impulsiveness Scale (BIS-11), nor produce changes in neural correlates of impulsivity (i.e. frontostriatal gray matter, functional connectivity, and dopamine levels) compared to active or wait-list control groups. Separately, long-term meditators (LTMs) did not perform differently than meditation-naïve participants (MNPs) on the go/no-go task. However, LTMs self-reported lower attentional impulsivity, but higher motor and non-planning impulsivity on the BIS-11 than MNPs. LTMs had less striatal gray matter, greater cortico-striatal-thalamic functional connectivity, and lower spontaneous eye-blink rate (a physiological dopamine indicator) than MNPs. LTM total lifetime practice hours (TLPH) did not signifcantly relate to impulsivity or neurobiological metrics. Findings suggest that neither short nor long-term mindfulness practice may be efective for redressing impulsive behavior derived from inhibitory motor control or planning capacity defcits in healthy adults. Given the absence of TLPH relationships to impulsivity or neurobiological metrics, diferences between LTMs and MNPs may be attributable to pre-existing diferences.

Gender and race stereotypes - what's in a name...

Eaton et al. give us more data on the application of gender and race stereotypes in academia:

The current study examines how intersecting stereotypes about gender and race influence faculty perceptions of post-doctoral candidates in STEM fields in the United States. Using a fully-crossed, between-subjects experimental design, biology and physics professors (n = 251) from eight large, public, U.S. research universities were asked to read one of eight identical curriculum vitae (CVs) depicting a hypothetical doctoral graduate applying for a post-doctoral position in their field, and rate them for competence, hireability, and likeability. The candidate’s name on the CV was used to manipulate race (Asian, Black, Latinx, and White) and gender (female or male), with all other aspects of the CV held constant across conditions. Faculty in physics exhibited a gender bias favoring the male candidates as more competent and more hirable than the otherwise identical female candidates. Further, physics faculty rated Asian and White candidates as more competent and hirable than Black and Latinx candidates, while those in biology rated Asian candidates as more competent and hirable than Black candidates, and as more hireable than Latinx candidates. An interaction between candidate gender and race emerged for those in physics, whereby Black women and Latinx women and men candidates were rated the lowest in hireability compared to all others. Women were rated more likeable than men candidates across departments. Our results highlight how understanding the underrepresentation of women and racial minorities in STEM requires examining both racial and gender biases as well as how they intersect.

Cognitive and Affective Neuroscience

I want to point the subset of MindBlog readers interested in brain-behavior correlations to the journal “Social Cognitive and Affective Neuroscience,” particularly to the June 2019 issue. Most of the articles in this issue are open source, and a scan of the article abstracts gives a good sense of the kind of work being done in this field to identify correlations between behaviors and brain activities in different brain areas. Such work gives us an idea of where to focus our attention when extreme behaviors are at issue, such as (in the first article) being willing to fight and die for a cause. Another interesting article suggests that the medial prefrontal cortex may play a role in maintaining a positively biased self-concept.

People of color - getting quantitative about police-involved deaths

From Edwards et al.:

Significance

Police violence is a leading cause of death for young men in the United States. Over the life course, about 1 in every 1,000 black men can expect to be killed by police. Risk of being killed by police peaks between the ages of 20 y and 35 y for men and women and for all racial and ethnic groups. Black women and men and American Indian and Alaska Native women and men are significantly more likely than white women and men to be killed by police. Latino men are also more likely to be killed by police than are white men.

Abstract

We use data on police-involved deaths to estimate how the risk of being killed by police use of force in the United States varies across social groups. We estimate the lifetime and age-specific risks of being killed by police by race and sex. We also provide estimates of the proportion of all deaths accounted for by police use of force. We find that African American men and women, American Indian/Alaska Native men and women, and Latino men face higher lifetime risk of being killed by police than do their white peers. We find that Latina women and Asian/Pacific Islander men and women face lower risk of being killed by police than do their white peers. Risk is highest for black men, who (at current levels of risk) face about a 1 in 1,000 chance of being killed by police over the life course. The average lifetime odds of being killed by police are about 1 in 2,000 for men and about 1 in 33,000 for women. Risk peaks between the ages of 20 y and 35 y for all groups. For young men of color, police use of force is among the leading causes of death.

Red and Blue Voters Live in Different Economies

Wow... if you want some graphics that powerfully describe our current political malaise, check out Edsall's Op-Ed piece in the NYTimes. Here is a graph showing how economic output and income for Democratic and Republican House districts diverged over the last decade - two different economies that are diverging rapidly:

Another Edsall piece notes that insecurity caused by rapid cultural change as well as economic insecurity has generated a class of voters who feel powerless and angry, and actually feel a need for the chaos Trump generates - that they hope might disrupt the system that disadvantages them.

Mindfulness training and attentional control of mind-wandering

Several studies have suggested that mindfulness training can strengthen the connections between the networks in our dorsolateral prefrontal cortex [DLPFC] attentional executive control network and those supporting the posterior cingulate cortex [PCC] default mode network active in mind-wandering. Davidson and his colleagues have expanded on this to see whether a Mindfulness-Based Stress Reduction (MBSR) course can increase DLPFC-PCC connectivity:

Mindfulness meditation training has been shown to increase resting state functional connectivity between nodes of the frontoparietal executive control network (dorsolateral prefrontal cortex [DLPFC]) and the default mode network (posterior cingulate cortex [PCC]). We investigated whether these effects generalized to a Mindfulness-Based Stress Reduction (MBSR) course, and tested for structural and behaviorally relevant consequences of change in connectivity. Healthy, meditationnaïve adults were randomized to either MBSR (N=48), an active (N=47) or waitlist (N=45) control group. Participants completed behavioral testing, resting state fMRI scans, and diffusion tensor scans at pre-randomization (T1), post-intervention (T2) and approximately 5.5 months later (T3). We found increased T2-T1 PCC–DLPFC resting connectivity for MBSR relative to control groups. Although these effects did not persist through long-term follow-up (T3-T1), MBSR participants showed a significantly stronger relationship between days of practice (T1 to T3) and increased PCC–DLPFC resting connectivity than participants in the active control group. Increased PCC–DLPFC resting connectivity in MBSR participants was associated with increased microstructural connectivity of a white matter tract connecting these regions, and increased self reported attention. These data show that MBSR increases PCC–DLPFC resting connectivity, which is related to increased practice time, attention, and structural connectivity.

Loving kindness meditation slows cellular aging?

I like to be generous, loving, kind and nice, but a recent PsyPost article on the slowing of cellular aging by loving-kindness meditation triggered my bullshit detector. I first pass on the summary and abstract of the work referenced in the article by Le Nguyen et al., and then get a bit into the details available only to those who have journal access (motivated readers can request a PDF of the article from me). It is a noble and complicated effort, with proper double blind controls, but with statistics compromised by a small sample size and measured changes in DNA telomere length (a proxy for aging) over a short period of time much larger than would be expected from longer terms studies. While I would like to believe the conclusions drawn by the authors, I have to remain wary of accepting them.

Highlights

•Over 12 weeks, loving-kindness meditation buffered telomere attrition.

•Telomere length decreased in the mindfulness group and the control group.

•The loving-kindness group showed less telomere attrition than the control group.

Abstract

Combinations of multiple meditation practices have been shown to reduce the attrition of telomeres, the protective caps of chromosomes (Carlson et al., Cancer, 121 (2015), pp. 476-484). Here, we probed the distinct effects on telomere length (TL) of mindfulness meditation (MM) and loving-kindness meditation (LKM). Midlife adults (N = 142) were randomized to be in a waitlist control condition or to learn either MM or LKM in a 6-week workshop. Telomere length was assessed 2 weeks before the start of the workshops and 3 weeks after their termination. After controlling for appropriate demographic covariates and baseline TL, we found TL decreased significantly in the MM group and the control group, but not in the LKM group. There was also significantly less TL attrition in the LKM group than the control group. The MM group showed changes in TL that were intermediate between the LKM and control groups yet not significantly different from either. Self-reported emotions and practice intensity (duration and frequency) did not mediate these observed group differences. This study is the first to disentangle the effects of LKM and MM on TL and suggests that LKM may buffer telomere attrition.

Fig. 1. Descriptive Mean and Standard Errors of Changes in TL per Experimental Conditions. (TL is expressed as the ratio (T/S) of telomeric (T) to single copy (S) gene product for a particular blood sample)

Apart from picking apart their statistics and the "controls for demographic covariates," the discussion paragraph that troubles me most is:

The difference in telomere length between the Control and LKM groups was .048 T/S ratio after demographic covariates were considered. Based on comparison of T/S ratios and telomere length measured by Southern blot in a series of quality control samples from the same lab, we estimated this difference of .048 T/S ratio to be 115 basepairs. This TL decrease over the 12-week period appears to be large compared to studies of TL change with much longer time periods (Müezzinler et al., Obes. Rev., 15 (2014), pp. 192-201). It is possible that this reflects short term dynamic change, or potential systematic differences in the collection and/or assay of baseline and follow-up samples. The fact that DNA extraction and assay were done as one batch (all samples from Time 1 and Time 2) argues against the latter concern, although we cannot completely rule out other potential unaccounted for systematic differences. Although it is unknown whether this effect remains longer than 3 weeks post-intervention, the current study demonstrated proof of concept for the malleability of TL changes, and that certain forms of meditation, in this case loving-kindness meditation, may buffer against telomere erosion.

After several paragraphs of other reservations and cautions on the data, the authors state:

...one should interpret the differences in TL changes here with caution, treating them as evidence for “apparent” rather than true alterations in TL.

In balance, the PsyPost article title: "Study provides evidence that loving-kindness meditation slows cellular aging" is wrong.

Gender neutral pronouns reduce bias in favor of traditional gender roles

An interesting study by Tavits and Pérez on Sweden's 2015 incorporation into the Swedish Academy Glossary (which sets norms for Sweden's language) of the gender-neutral pronoun hen. A majority of Swedes now use hen alongside the explicitly gendered hon (she) and han (he) as part of their grammatical toolkit.

Significance

Evidence from 3 survey experiments traces the effects of gender-neutral pronoun use on mass judgments of gender equality and tolerance toward lesbian, gay, bisexual, and transgender (LGBT) communities. The results establish that individual use of gender-neutral pronouns reduces the mental salience of males. This shift is associated with people expressing less bias in favor of traditional gender roles and categories, as manifested in more positive attitudes toward women and LGBT individuals in public affairs.

Abstract

To improve gender equality and tolerance toward lesbian, gay, bisexual, and transgender (LGBT) communities, several nations have promoted the use of gender-neutral pronouns and words. Do these linguistic devices actually reduce biases that favor men over women, gays, lesbians, and transgender individuals? The current article explores this question with 3 large-scale experiments in Sweden, which formally incorporated a gender-neutral pronoun into its language alongside established gendered pronouns equivalent to he and she. The evidence shows that compared with masculine pronouns, use of gender-neutral pronouns decreases the mental salience of males. This shift is associated with individuals expressing less bias in favor of traditional gender roles and categories, as reflected in more favorable attitudes toward women and LGBT individuals in public life. Additional analyses reveal similar patterns for feminine pronouns. The influence of both pronouns is more automatic than controlled.

The power of "cute"

I want to point MindBlog readers to an article by Simon May at aeon.co that encapsulates the contents of his new book "The Power of Cute" (2019), and to a Trends in Cognitive Sciences review article by Kringelbach et al. on cuteness that summarizes work on brain activities underlying survival related cuteness responses. The latter article's introduction notes that the prevailing view of cuteness...

...came from the founding fathers of ethology, Nobel prizewinners Konrad Lorenz and Niko Tinbergen. They proposed that the cute facial features of infants form a ‘Kindchenschema’ (infant schema), a prime example of an ‘innate releasing mechanism’ that unlocks instinctual behaviours...These characteristics contribute to ‘cuteness’ and propel our caregiving behaviours, which is vital because infants need our constant attention to survive and thrive. Infants attract us through all our senses, which helps make cuteness one of the most basic and powerful forces shaping our behaviour.

May considers the increasing popularity of child-like figures in popular culture and asks:

In such uncertain and uneasy times, and with so much injustice, hate and intolerance threatening the world, don’t we have more serious things to focus on than the escapades of that feline girl-figure Hello Kitty? Or Pokémon, the video-game franchise that’s hot again in 2019...The craze for all things cute is motivated, most obviously, by the urge to escape from precisely such a threatening world into a garden of innocence in which childlike qualities arouse deliciously protective feelings, and bestow contentment and solace. Cute cues include behaviours that appear helpless, harmless, charming and yielding, and anatomical features such as outsize heads, protruding foreheads, saucer-like eyes, retreating chins and clumsy gaits.

May suggests that the increasingly popularity of cuteness derives not only from the 'sweet' end of the whole spectrum of cuteness but also from moving towards the 'uncanny' and ambiguous end, a....

...faintly menacing subversion of boundaries – between the fragile and the resilient, the reassuring and the unsettling, the innocent and the knowing – when presented in cute’s frivolous, teasing idiom, is central to its immense popularity... ‘unpindownability’, as we might call it, that pervades cute – the erosion of borders between what used to be seen as distinct or discontinuous realms, such as childhood and adulthood – is also reflected in the blurred gender of many cute objects such as Balloon Dog or a lot of Pokémon. It is reflected, too, in their frequent blending of human and nonhuman forms, as in the cat-girl Hello Kitty. And in their often undefinable age...In such ways, cute is attuned to an era that is no longer so wedded to such hallowed dichotomies as masculine and feminine, sexual and nonsexual, adult and child, being and becoming, transient and eternal, body and soul, absolute and contingent, and even good and bad.

Although attraction to such cute objects as the mouthless, fingerless Hello Kitty can express a desire for power, cuteness can also parody and subvert power by playing with the viewer’s sense of her own power, now painting her into a dominant pose, now sowing uncertainty about who is really in charge...

Psychological adaptation to the apocalypse - meditate, or just be happy?

In this post, not exactly an upper, I point first to two in-your-face articles on how we ought to be afraid, very afraid, about humanity's future technological and ecological environment, and then note two pieces of writing on psychological adaptations that might dampen down the full turn on of our brains' fear machinery.

Novelist Jonathan Franzen does a screed very effective at scaring the bejesus out of us. His basic argument: “The climate apocalypse is coming. To prepare for it, we need to admit that we can’t prevent it.” A chorus of criticism has greeted Franzen's article: "Franzen is wrong on the science, on the politics, and on the psychology of human behavior as it pertains to climate change." (See also Chrobak.)

And, for alarm on our looming digital environment, The 6,000 word essay by Glenn S. Gerstell, general counsel of the National Security, and summarized by Warzel, should do the job. The first nation to crack quantum computing (China or the US) will rule the world! 

So, how do we manage to wake up cheerful in the morning? Futurist Yuval Harari offers his approach in Chapter 21 of his book "21 Lessons for the 21st century," by describing his experience of learning to meditate, starting with the initial instructions (to observe your process of breathing) in his first Vipassana meditation course. He now meditates two hours every day.

The point is that meditation is a tool for observing the mind directly...For at least two hours a day I actually observe reality as it is, while for the other twenty-two hours I get overwhelmed by emails and tweets and cute-puppy videos. Without the focus and clarity provided by this practice, I could not have written Sapiens or Homo Deus.

A glimmer of hopefulness can also be obtained by reading books in the vein of Pinker's "Enlightenment Now", which documents again and again, for many areas, how dire predictions about the future have not come to pass. The injunction here would be to be optimistic, not a bad idea, given the recent PNAS article by Lee et al. documenting that the lifespan of optimistic people, on average, is 11 to 15% longer.

Twitter is making us dumber.

Stanley-Becker points to some research providing hardly surprising evidence that communicating about complex issues using 280 character chunks of text dumbs down the understanding of twitter users. Using Twitter to teach literature has an overall negative effect on students’ average achievement, with the effect being strongest on students who usually perform better. Numerous schools have started to utilize twitter discussion among students assuming that this would enhance intellectual attainment, but in fact it undermines it.

Can we reverse our biological age? The usual media hysteria...

I must have seen at least 10 of my media inputs hyping a small study by Fahy et al. (9 white men, and lacking controls) pointed to by Abbott suggesting that the body's epigenetic clock might be reversed. The study actually had the goal of seeing whether human growth hormone could stimulates regeneration of the thymus gland and enhance immune function. Because the hormone can promote diabetes, the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone (DHEA) and metformin, in the treatment cocktail. (Metformin is being evaluated as an anti-aging drug in several large scale studies).

Checking the effect of the drugs on the participants’ epigenetic clocks was an afterthought. The clinical study had finished when Fahy approached Horvath to conduct an analysis. (Epigenetic clocks are constructed by selecting sets of DNA-methylation sites across the genome. In the past few years, Horvath — a pioneer in epigenetic-clock research — has developed some of the most accurate ones)...Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests. “This told me that the biological effect of the treatment was robust,” he says. What’s more, the effect persisted in the six participants who provided a final blood sample six months after stopping the trial, he says.

The understandable excitement over this result is probably out of proportion to the probability it will be confirmed in larger experiments with proper controls.

Training to reduce cognitive biases.

Sellier et al. show that students assigned to solve a business case exercise are less likely to choose an inferior confirmatory solution when they have previously undergone a debiasing-training intervention:

The primary objection to debiasing-training interventions is a lack of evidence that they improve decision making in field settings, where reminders of bias are absent. We gave graduate students in three professional programs (N = 290) a one-shot training intervention that reduces confirmation bias in laboratory experiments. Natural variance in the training schedule assigned participants to receive training before or after solving an unannounced business case modeled on the decision to launch the Space Shuttle Challenger. We used case solutions to surreptitiously measure participants’ susceptibility to confirmation bias. Trained participants were 29% less likely to choose the inferior hypothesis-confirming solution than untrained participants. Analysis of case write-ups suggests that a reduction in confirmatory hypothesis testing accounts for their improved decision making in the case. The results provide promising evidence that debiasing-training effects transfer to field settings and can improve decision making in professional and private life.

How personal and professional conduct relate to one another.

From Griffin et al.:

Significance

The relative importance of personal traits compared with context for predicting behavior is a long-standing issue in psychology. This debate plays out in a practical way every time an employer, voter, or other decision maker has to infer expected professional conduct based on observed personal behavior. Despite its theoretical and practical importance, there is little academic consensus on this question. We fill this void with evidence connecting personal infidelity to professional behavior in 4 different settings.

Abstract

We study the connection between personal and professional behavior by introducing usage of a marital infidelity website as a measure of personal conduct. Police officers and financial advisors who use the infidelity website are significantly more likely to engage in professional misconduct. Results are similar for US Securities and Exchange Commission (SEC) defendants accused of white-collar crimes, and companies with chief executive officers (CEOs) or chief financial officers (CFOs) who use the website are more than twice as likely to engage in corporate misconduct. The relation is not explained by a wide range of regional, firm, executive, and cultural variables. These findings suggest that personal and workplace behavior are closely related.

Training wisdom - the Illeist (third person) method.

I think my most sane moments are those when I experience myself as watching, in third-person mode, rather than “being” Deric, the immersed actor. Science journalist David Robson does an essay on this perspective in Aeon, “Why speaking to yourself in the third person makes you wiser,” noting that this ancient rhetorical method, used by Julius Caesar and termed ‘illeism’ in 1809 by the poet Coleridge (latin ille meaning ‘he, that’) can clear the emotional fog of simple rumination, shifting perspective to see past biases. Robson notes the work of Igor Grossmann at the University of Waterloo in Canada, whose aim is:

...to build a strong experimental footing for the study of wisdom, which had long been considered too nebulous for scientific enquiry. In one of his earlier experiments, he established that it’s possible to measure wise reasoning and that, as with IQ, people’s scores matter. He did this by asking participants to discuss out-loud a personal or political dilemma, which he then scored on various elements of thinking long-considered crucial to wisdom, including: intellectual humility; taking the perspective of others; recognising uncertainty; and having the capacity to search for a compromise. Grossmann found that these wise-reasoning scores were far better than intelligence tests at predicting emotional wellbeing, and relationship satisfaction – supporting the idea that wisdom, as defined by these qualities, constitutes a unique construct that determines how we navigate life challenges.

The abstract from Grossmann et al.:

We tested the utility of illeism – a practice of referring to oneself in the third person – for the trainability of wisdom-related characteristics in everyday life: i) wise reasoning (intellectual humility, open-mindedness in ways a situation may unfold, perspective-taking, attempts to integrate different viewpoints) and ii) accuracy in emotional forecasts toward close others. In a month-long field experiment, people adopted either the third-person training or first-person control perspective when describing their most significant daily experiences. Assessment of spontaneous wise reasoning before and after the intervention revealed substantial growth in the training (vs. control) condition. At the end of the intervention, people forecasted their feelings toward a close other in challenging situations. A month later, these forecasted feelings were compared against their experienced feelings. Participants in the training (vs. control) condition showed greater alignment of forecasts and experiences, largely due to changes in their emotional experiences. The present research demonstrates a path to evidence-based training of wisdom-related processes via the practice of illeism.

Robson finds this work particularly fascinating,

...considering the fact that illeism is often considered to be infantile. Just think of Elmo in the children’s TV show Sesame Street, or the intensely irritating Jimmy in the sitcom Seinfeld – hardly models of sophisticated thinking. Alternatively, it can be taken to be the sign of a narcissistic personality – the very opposite of personal wisdom. After all, Coleridge believed that it was a ruse to cover up one’s own egotism: just think of the US president’s critics who point out that Donald Trump often refers to himself in the third person. Clearly, politicians might use illeism for purely rhetorical purposes but, when applied to genuine reflection, it appears to be a powerful tool for wiser reasoning.

For an example of third person usage reflecting not wisdom, but a narcissistic personality, look no further than our current president, Donald Trump, as noted in this Washington Post piece by Rieger.

Infants expect leaders to right wrongs

From Stavans and Baillargeon:

Anthropological and psychological research on direct third-party punishment suggests that adults expect the leaders of social groups to intervene in within-group transgressions. Here, we explored the developmental roots of this expectation. In violation-of-expectation experiments, we asked whether 17-mo-old infants (n = 120) would expect a leader to intervene when observing a within-group fairness transgression but would hold no particular expectation for intervention when a nonleader observed the same transgression. Infants watched a group of 3 bear puppets who served as the protagonist, wrongdoer, and victim. The protagonist brought in 2 toys for the other bears to share, but the wrongdoer seized both toys, leaving none for the victim. The protagonist then either took 1 toy away from the wrongdoer and gave it to the victim (intervention event) or approached each bear in turn without redistributing a toy (nonintervention event). Across conditions, the protagonist was either a leader (leader condition) or a nonleader equal in rank to the other bears (nonleader condition); across experiments, leadership was marked by either behavioral or physical cues. In both experiments, infants in the leader condition looked significantly longer if shown the nonintervention as opposed to the intervention event, suggesting that they expected the leader to intervene and rectify the wrongdoer’s transgression. In contrast, infants in the nonleader condition looked equally at the events, suggesting that they held no particular expectation for intervention from the nonleader. By the second year of life, infants thus already ascribe unique responsibilities to leaders, including that of righting wrongs.

Loss of control in aging cells.

Wow...experiments like those of Pereda et al. make me feel rather fatalistic and resigned to the aging process, notwithstanding all the numerous pie in the sky biotech startups that are trying to find magic bullets that will reverse human aging. They note that deterioration in learning and memory with aging is not accompanied by obvious increases in nerve cell death, and so looked for more subtle changes that might be a play. They created transgenic mice that expressed a calcium sensor specifically in presynaptic terminals of the CA1 region of the hippocampus, allowing them to measure how calcium signaling altered with age. Older animals showed increased calcium influx into the neurons and persistently increased concentration of calcium in resting neurons, most likely caused by by an age‐dependent change in the properties or numbers of presynaptic calcium channels. Higher calcium altered neuronal transmission with parallel loss of cognitive function in the animals. Interestingly, reducing extracellular calcium made old synapses behave more like younger ones, and raising extracellular calcium made young synapses act like old ones.  Here is their technical abstract:

The loss of cognitive function accompanying healthy aging is not associated with extensive or characteristic patterns of cell death, suggesting it is caused by more subtle changes in synaptic properties. In the hippocampal CA1 region, long‐term potentiation requires stronger stimulation for induction in aged rats and mice and long‐term depression becomes more prevalent. An age‐dependent impairment of postsynaptic calcium homeostasis may underpin these effects. We have examined changes in presynaptic calcium signalling in aged mice using a transgenic mouse line (SyG37) that expresses a genetically encoded calcium sensor in presynaptic terminals. SyG37 mice showed an age‐dependent decline in cognitive abilities in behavioural tasks that require hippocampal processing including the Barnes maze, T‐maze and object location but not recognition tests. The incidence of LTP was significantly impaired in animals over 18 months of age. These effects of aging were accompanied by a persistent increase in resting presynaptic calcium, an increase in the presynaptic calcium signal following Schaffer collateral fibre stimulation, an increase in postsynaptic fEPSP slope and a reduction in paired‐pulse facilitation. These effects were not caused by synapse proliferation and were of presynaptic origin since they were evident in single presynaptic boutons. Aged synapses behaved like younger ones when the extracellular calcium concentration was reduced. Raising extracellular calcium had little effect on aged synapses but altered the properties of young synapses into those of their aged counterparts. These effects can be readily explained by an age‐dependent change in the properties or numbers of presynaptic calcium channels.

Interindividual variability - rather than universality - in facial-emotion perception.

Brooks et al. do experiments suggesting that the representational structure of emotion expressions in visual face-processing regions may be shaped by idiosyncratic conceptual understanding of emotion categories:

Significance

Classic theories of emotion hold that emotion categories (e.g., Anger and Sadness) each have corresponding facial expressions that can be universally recognized. Alternative approaches emphasize that a perceiver’s unique conceptual knowledge (e.g., memories, associations, and expectations) about emotions can substantially interact with processing of facial cues, leading to interindividual variability—rather than universality—in facial-emotion perception. We find that each individual’s conceptual structure significantly predicts the brain’s representational structure, over and above the influence of facial features. Conceptual structure also predicts multiple behavioral patterns of emotion perception, including cross-cultural differences in patterns of emotion categorizations. These findings suggest that emotion perception, and the brain’s representations of face categories, can be flexibly influenced by conceptual understanding of emotions.

Abstract

Humans reliably categorize configurations of facial actions into specific emotion categories, leading some to argue that this process is invariant between individuals and cultures. However, growing behavioral evidence suggests that factors such as emotion-concept knowledge may shape the way emotions are visually perceived, leading to variability—rather than universality—in facial-emotion perception. Understanding variability in emotion perception is only emerging, and the neural basis of any impact from the structure of emotion-concept knowledge remains unknown. In a neuroimaging study, we used a representational similarity analysis (RSA) approach to measure the correspondence between the conceptual, perceptual, and neural representational structures of the six emotion categories Anger, Disgust, Fear, Happiness, Sadness, and Surprise. We found that subjects exhibited individual differences in their conceptual structure of emotions, which predicted their own unique perceptual structure. When viewing faces, the representational structure of multivoxel patterns in the right fusiform gyrus was significantly predicted by a subject’s unique conceptual structure, even when controlling for potential physical similarity in the faces themselves. Finally, cross-cultural differences in emotion perception were also observed, which could be explained by individual differences in conceptual structure. Our results suggest that the representational structure of emotion expressions in visual face-processing regions may be shaped by idiosyncratic conceptual understanding of emotion categories.

From "Love Your Enemies" - Arthur Brooks on Haidt's Moral Foundations Theory

I have read through Arthur Brooks' new book, "Love your Enemies," which addresses the many facets of our current political polarization, with the goal of suggesting some ways to ameliorate our current impasse. While I'm tempted to pass on an abstracted version of the main points of each of the book chapters, as I have done for several other books that have influenced me, I'm going to restrict myself to passing on some clips from Chapter 4 "How Can I Love my Enemies if They are Immoral," in which he does a nice summary of the ideas and work of Jonathan Haidt. At the end of the clips I attach a graphic from one of Haidt's lectures that summarizes his findings.

...“moral foundations theory,”... specifically addresses how conservatives and liberals differ in their moral views. Haidt was finding that certain ideas of morality are innate and that “the worst idea in all of psychology is the idea that the mind is a blank slate at birth.”* His research showed that we are in fact born with particular moral foundations that make it easy for us to learn certain ideas of right and wrong, and hard to learn others. Using survey data for hundreds of thousands of individuals, Haidt was finding that there are in fact five innate moral values that exist among humans of all races and cultures, which he calls the “five foundations of morality.” They are: (1) fairness, (2) care for others, (3) respect for authority, (4) loyalty to one’s group, and (5) purity or sanctity. (Later, he added liberty to the list.) Haidt’s research has shown that of these five moral foundations, the first two—fairness and care—are nearly universal. Except for sociopaths, almost everyone—conservative or liberal, young or old, religious or nonreligious—believes in fairness and compassion to others.

Conservatives look at all this and often conclude that liberals are less moral than they are, but the science shows this is not true. Liberals are not less moral; they simply have fewer moral foundations. According to Haidt’s research, “Liberals have a kind of a two-channel, or two-foundation morality” while “conservatives have more of a . . . five-channel morality.” All of us, regardless of where we sit on the political spectrum, care about social morality, treating others with fairness and compassion. By contrast, personal moral values, such as sexual purity, respect for authority, and tribal loyalty—to which conservative politicians often give greater emphasis—resonate deeply with only a part of the population. When it comes to loyalty, authority, and purity, conservatives are from Mars, and liberals are from Venus. Or vice versa, I’m not sure. I just know it’s different planets.

Even in an age that celebrates diversity, most people assiduously avoid those who hold different moral values. Indeed, people avoid those with different values more than they do people of different racial backgrounds. In one study with undergraduate students, Haidt and his colleagues found that “in fraternity admissions, fraternity brothers were happy to admit people who were demographically different from themselves, although they avoided candidates who had strong moral or political values that differed either from the group as a whole, or from themselves as individuals.” He also found that in choosing a study partner, most undergraduates did not care about racial differences, “but political/moral differences generally made a candidate less attractive.” Haidt’s work is consistent with more recent research that shows the starkest dividing line in America today is not race, religion, or economic status, but rather party affiliation. In fact, scholars at Stanford and Princeton have found that political partisans in America now take a more discriminatory view of those in the opposing party than they do of people of other races.

You may be genetically predisposed to a conservative, five-channel moral foundation, but that doesn’t mean you have to be a conservative if your intellect tells you otherwise. Think deeply. Listen to the other side. Reflect on what others are saying. Then ask yourself not just how you feel, but what you think is right. We’re not slaves. We’re not shackled to a pipe in the basement of our own built-in genetic morality. In his book The Birth of the Mind, the eminent brain scientist Gary Marcus writes, “‘Built-in’ does not mean unmalleable; it means organized in advance of experience.” When it comes to our moral outlook, Marcus says, “Nature provides a first draft, which experience then revises.” It is up to each of us to create the next drafts of our moral minds. We should constantly be evaluating whether our particular expression of our moral values is the right one, much less the only legitimate expression of those values. Doing so requires the humility to recognize that none of us has a monopoly on truth. The left favors redistribution; the right, meritocracy. But if we had a completely redistributionist society we’d be the Soviet Union; if we had a complete meritocracy, millions would be starving. There is a sweet spot between the two and we should all be searching together to find it.

What we see is biased by ongoing neural activity.

Rassi et al. (open source) show that ongoing neural activity in our brain, as in the fusiform face area, can influence what we perceive in an ambiguous sensory stimulus such as the Rubin face/vase illusion.

Significance

Ongoing neural activity influences stimulus detection—that is, whether or not an object is seen. Here, we uncover how it could influence the content of what is seen. In ambiguous situations, for instance, ongoing neural fluctuations might bias perception toward one or the other interpretation. Indeed, we show increased information flow from category-selective brain regions (here, the fusiform face area [FFA]) to the primary visual cortex before participants subsequently report seeing faces rather than a vase in the Rubin face/vase illusion. Our results identify a neural connectivity pathway that biases future perception and helps determine mental content.

Abstract

Ongoing fluctuations in neural excitability and in networkwide activity patterns before stimulus onset have been proposed to underlie variability in near-threshold stimulus detection paradigms—that is, whether or not an object is perceived. Here, we investigated the impact of prestimulus neural fluctuations on the content of perception—that is, whether one or another object is perceived. We recorded neural activity with magnetoencephalography (MEG) before and while participants briefly viewed an ambiguous image, the Rubin face/vase illusion, and required them to report their perceived interpretation in each trial. Using multivariate pattern analysis, we showed robust decoding of the perceptual report during the poststimulus period. Applying source localization to the classifier weights suggested early recruitment of primary visual cortex (V1) and ∼160-ms recruitment of the category-sensitive fusiform face area (FFA). These poststimulus effects were accompanied by stronger oscillatory power in the gamma frequency band for face vs. vase reports. In prestimulus intervals, we found no differences in oscillatory power between face vs. vase reports in V1 or in FFA, indicating similar levels of neural excitability. Despite this, we found stronger connectivity between V1 and FFA before face reports for low-frequency oscillations. Specifically, the strength of prestimulus feedback connectivity (i.e., Granger causality) from FFA to V1 predicted not only the category of the upcoming percept but also the strength of poststimulus neural activity associated with the percept. Our work shows that prestimulus network states can help shape future processing in category-sensitive brain regions and in this way bias the content of visual experiences.

More diversity in Flow-land.

I will pass on part of an email from Mr. Todd Denen occasioned by my 8/16/19 post, in which he assures me, that unlike the Flow Genome Project and Flow Collective Research Project discussed in that post, his Flow Research University is legit:

“ My name is Todd Denen and I just came across your post on the FGP guys. I just wanted to say not all Flow training programs are bullshit.....

I'm the founder of the Advanced Flow University which teaches the Flow state from the perspective of the Yogi Flow Experts.

In my book, PEAK PERFORMANCE SECRETS, I reveal the Advanced Flow Techniques which have been used by the Yogi Flow Experts for over 5,000 years. This has allowed them to achieve the highest level of Consciousness, the 7th Level of Flow.

If you are interested, I'm doing a promotion on it right now and you can get it for free on Amazon….."

Here is a screen shot showing only three of the numerous free books by Mr. Denen available from Amazon's Kindle offerings.

I couldn't resist downloading and having a look at "Peak Performance Secrets" and "FLOW STATE SEX TEST" (Advanced Flow University Book 3).

Unbelievable stuff.   Kudos to Amazon for its carefully vetted high quality Kindle offerings!

What we see is influenced by what we can do about it

Djebbara et al. do experiments that resolve an ancient debate on the relationship between cognition, movement, and environment, showing that potential actions afforded by an architectural environment influence perception. We perceive the world not as an observer-independent reality but in the mold of potential actions, shaped by the current needs and other personal attributes of the actor–perceiver. I pass on their significance and abstract statements, and then a clip from a description of the work by Gepshtein and Snider.

Significance

Using electroencephalography and virtual reality, our research provides a unique perspective on the centuries-old open-ended debate in cognitive neuroscience and philosophy on the relationship among cognition, movement, and environment. Our results indicate that cortical potentials vary as a function of bodily affordances reflected by the physical environment. First, the results imply that cognition is inherently related to the potential movement of the body; thus, we posit that action is interrelated with perception, actively influencing the perceivable environment. Second, these results indicate that moving in space is to continuously construct a prediction of a world of affordances, suggesting that architects take up the continuity of spaces, given that the unfolding of bodily movement alters perception and experience.

Abstract

Anticipating meaningful actions in the environment is an essential function of the brain. Such predictive mechanisms originate from the motor system and allow for inferring actions from environmental affordances, and the potential to act within a specific environment. Using architecture, we provide a unique perspective on the ongoing debate in cognitive neuroscience and philosophy on whether cognition depends on movement or is decoupled from our physical structure. To investigate cognitive processes associated with architectural affordances, we used a mobile brain/body imaging approach recording brain activity synchronized to head-mounted displays. Participants perceived and acted on virtual transitions ranging from nonpassable to easily passable. We found that early sensory brain activity, on revealing the environment and before actual movement, differed as a function of affordances. In addition, movement through transitions was preceded by a motor-related negative component that also depended on affordances. Our results suggest that potential actions afforded by an environment influence perception.

And, the clip from the review by Gepshtein and Snider:

Djebbara et al. had human participants walking freely while immersed in a virtual environment. A wearable “brain/body imaging setup” included a 64-channel electroencephalographic (EEG) cap that allowed researchers to record the participants’ electrical activity of the brain. The experiment consisted of a series of trials in which participants confronted simulated doors of different widths: Narrow (0.2 m wide), medium (1 m), and wide (1.5 m). At the onset of every trial, the participant was shown 1 of the 3 doors for several seconds. Then the wall framing the door changed its color: To green, prompting the person to pass through the door (the Go condition), or to red, indicating that the person should not approach the door (NoGo). A key result from the analysis of the participants’ brain activity came from the temporal window that just followed the Go/NoGo signal. On average, the part of the brain responsible for processing visual information functioned differently in the Go and NoGo conditions. In the Go condition, brain activity depended significantly on whether the door was passable or not, but in the NoGo condition, no such difference was found.

The authors explain this result by evoking the familiar concept of affordance, introduced by the influential American psychologist James J. Gibson in 1966. Gibson coined the term “affordance” to designate action opportunities offered by objects, trying to find a substitute to the term “value” which he worried would carry “an old burden of philosophical meaning”