Ability to use symbols appeared 35 million years ago?

Humans are sometimes said to be distinguished as "The Symbolic Species." A Research Highlights note in Nature point to the work of Addessi et al., who show that capuchin monkeys, who diverged from the human lineage ~35 million years ago, can be trained to use and assign value to tokens (symbols) for different items of food.

...Elsa Addessi of the CNR, Italy's national research council, and her colleagues trained five monkeys to associate a particular token — such as a green chip, black plastic tube or a brass hook — with one of three specific types of food. They then gave the monkeys a series of choices, each time between different amounts of two food items or between two types of token...The value the monkeys assigned to a token was very similar to the value they gave to the food it represented, which suggests that the animals weighed up both real and symbolic options in an equivalent manner.

Cultural evolution in the laboratory

Kirby et al. offer experimental validation for the idea that cultural transmission can lead to the appearance of design without a designer. The abstract is below, and the experimental design best appreciated by examining the paper here:

We introduce an experimental paradigm for studying the cumulative cultural evolution of language. In doing so we provide the first experimental validation for the idea that cultural transmission can lead to the appearance of design without a designer. Our experiments involve the iterated learning of artificial languages by human participants. We show that languages transmitted culturally evolve in such a way as to maximize their own transmissibility: over time, the languages in our experiments become easier to learn and increasingly structured. Furthermore, this structure emerges purely as a consequence of the transmission of language over generations, without any intentional design on the part of individual language learners. Previous computational and mathematical models suggest that iterated learning provides an explanation for the structure of human language and link particular aspects of linguistic structure with particular constraints acting on language during its transmission. The experimental work presented here shows that the predictions of these models, and models of cultural evolution more generally, can be tested in the laboratory.

Intelligence enhancing software - continued...

I wanted to bring into this separate post a comment from blog reader Erik, made below. You don't have to own an iPhone and pay six bucks to do the dual-n-back tests. Erik's comment:

Hey. I'd just add that there are some accurate dual-n-back implementations on the web. Ours is open source, and it's here: dual n back implementation . It follows the protocol very closely, and it even got a thumbs up from the researchers.

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Do our noses sniff danger in the air?

The Grueneberg ganglion is a recently discovered ball of olfactory nerve cells found at the tip of the noses of mammals, including us. It turns out that, in mice, it is responsible for detecting alarm pheromones of the sort that are secreted by both plants and animals to warn conspecifics of a threatening situation. (There is speculation about human pheromones as an factor in emotional state before death). Chang points to some definitive work in mice from Brechbühl et al. Here is their abstract:

Alarm pheromones (APs) are widely used throughout the plant and animal kingdoms. Species such as fish, insects, and mammals signal danger to conspecifics by releasing volatile alarm molecules. Thus far, neither the chemicals, their bodily source, nor the sensory system involved in their detection have been isolated or identified in mammals. We found that APs are recognized by the Grueneberg ganglion (GG), a recently discovered olfactory subsystem. We showed with electron microscopy that GG neurons bear primary cilia, with cell bodies ensheathed by glial cells. APs evoked calcium responses in GG neurons in vitro and induced freezing behavior in vivo, which completely disappeared when the GG degenerated after axotomy. We conclude that mice detect APs through the activation of olfactory GG neurons.

The discovery of structural form

Charles Kemp and Tenenbaum present a computational model that learns structures of many different forms and that discovers which form is best for a given dataset. Their article in PNAS is open access, so you can follow this link to the detailed discussion and figures.

Algorithms for finding structure in data have become increasingly important both as tools for scientific data analysis and as models of human learning, yet they suffer from a critical limitation. Scientists discover qualitatively new forms of structure in observed data: For instance, Linnaeus recognized the hierarchical organization of biological species, and Mendeleev recognized the periodic structure of the chemical elements. Analogous insights play a pivotal role in cognitive development: Children discover that object category labels can be organized into hierarchies, friendship networks are organized into cliques, and comparative relations (e.g., “bigger than” or “better than”) respect a transitive order. Standard algorithms, however, can only learn structures of a single form that must be specified in advance: For instance, algorithms for hierarchical clustering create tree structures, whereas algorithms for dimensionality-reduction create low-dimensional spaces. Here, we present a computational model that learns structures of many different forms and that discovers which form is best for a given dataset. The model makes probabilistic inferences over a space of graph grammars representing trees, linear orders, multidimensional spaces, rings, dominance hierarchies, cliques, and other forms and successfully discovers the underlying structure of a variety of physical, biological, and social domains. Our approach brings structure learning methods closer to human abilities and may lead to a deeper computational understanding of cognitive development.

New software for your iPhone to make you smart

In a previous post I have mentioned the work of Jaeggi et al. who have shown that fluid intelligence, the ability to reason and to solve new problems independently of previously acquired knowledge, can be improved by training of working memory. Now their basic experimental paradigm is available as an iPhone app costing six bucks. I'm playing with it, and it has hooked me, unlike the web based stuff I have described previously. Here is a more thorough presentation of the paradigm of Jaeggi et al. than I gave in the original post:

In this task, participants see two series of stimuli that are synchronously presented at the rate of 3 s per stimulus. One string of stimuli consists of single letters whereas the other consists of individual spatial locations marked on a screen. The task is to decide for each string whether the current stimulus matched the one that was presented n items back in the series. The value of n varies from one block of trials to another, with adjustments made continuously for each participant based on performance. As performance improves, n increments by one item; as it worsens, n decrements by one item. Thus, the task changes adaptively so that it always remained demanding, and this demand is tailored to individual participants. This form of training engages processes required for the management of two simultaneous tasks; it engaged executive processes required for each task; and it discouraged the development of task-specific strategies and the engagement of automatic processes because of the variation in n and because of the inclusion of two different classes of stimuli.


The n-back task that is used as the training task, illustrated for a 2-back condition. The letters are presented auditorily at the same rate as the spatial material is presented visually.

Evolution "for the Good of the Group"

David S. Wilson and Edwin O. Wilson write a very clear summary in American Scientist, with title of this post, of the main features of group selection theory - which describes how natural selection takes place at multiple levels: genes, individuals, group of individuals. Below is an excerpt, and here is the PDF.

To think clearly about group selection, it is important to compare the survival and reproduction of individuals in the right way. The problem with "for the good of the group" behaviors is that they are locally disadvantageous. A prudent member of the herd might gain from conserving resources, but cheaters within the same group gain even more. Natural selection is based on relative fitness. If solid citizens are less fit than cheaters within their own group, then something more is required to explain how they can evolve in the total population. That something is a positive fitness difference at a larger scale. Groups of solid citizens are more fit than groups of cheaters.

Figure - Multilevel selection theory describes a hierarchy of evolutionary processes organized like nested Russian dolls. At the innermost level, within a single organism, genes contend with each other for a place in the next generation; within a group of organisms, selection acts on the relative fitness of individuals; groups within a population also differ in their collective survival and reproduction. Adaptation at any given level tends to be undermined by selection at lower levels. At even higher levels (not shown), populations, multispecies communities and whole ecosystems can be subject to selection.

These interacting layers of competition and evolution are like Russian matryoshka dolls nested one within another. At each level in the hierarchy natural selection favors a different set of adaptations. Selection between individuals within groups favors cheating behaviors, even at the expense of the group as a whole. Selection between groups within the total population favors behaviors that increase the relative fitness of the whole group—although these behaviors, too, can have negative effects at a still-larger scale. We can extend the hierarchy downward to study selection between genes within a single organism, or upward to study selection between even higher-level entities. The general rule is: Adaptation at level X requires a corresponding process of selection at level X and tends to be undermined by selection at lower levels.

This way of thinking about evolution is called multilevel selection (MLS) theory. Although the term "multilevel selection" is newer than the term "group selection," the Russian-doll logic has been present from the beginning, going back to the works of Darwin.

Darwin would not have been motivated to think about group selection were it not for the existence of traits that are selectively disadvantageous within groups. In a famous passage from Descent of Man, he notes that morally upright people do not have an obvious advantage over less-upright people within their own "tribe," but that tribes of morally upright people would robustly outcompete other tribes. He concluded by saying "... and this would be natural selection." Darwin was clearly employing the Russian-doll logic of MLS theory in this passage. He did not comment on the irony that morality expressed within groups can become morally problematic in between-group interactions, but his hypothetical example perfectly illustrates the general rule stated above, which makes adaptations at one level part of the problem at higher levels.

Brain Candy

Daniel Levitin writes a review of "Human - What Makes Us Unique" by Michael S. Gazzaniga which is worth a look. Also, Levitin has new book out which I have just ordered: "The World in Six Songs: How the Musical Brain Created Human Nature." From the Publisher's weekly review:

Charles Darwin meets the Beatles in this attempt to blend neuroscience and evolutionary biology to explain why music is such a powerful force. In this rewarding though often repetitious study by bestselling author Levitin (This Is Your Brain on Music), a rock musician turned neuroscientist, argues that music is a core element of human identity, paving the way for language, cooperative work projects and the recording of our lives and history. Through his studies, Levitin has identified six kinds of songs that help us achieve these goals: songs of friendship, joy, comfort, knowledge, religion and love. He cites lyrics ranging from the songs of Johnny Cash to work songs, which, he says, promote feelings of togetherness. According to Levitin, evolution may have selected individuals who were able to use nonviolent means like dance and music to settle disputes. Songs also serve as memory-aids, as records of our lives and legends. Some may find Levitin's evolutionary explanations reductionist, but he lightens the science with personal anecdotes and chats with Sting and others, offering an intriguing explanation for the power of music in our lives as individuals and as a society.

Note added 8/28... A very negative critical review of this Levitin book, by John Carmody, has just appeared in Nature. Now I'm thinking maybe I shouldn't have ordered it.

Phantom Penises In Transsexuals

In an article in the Journal of Consciousness Studies, Ramachandran and McGeoch offer evidence of an innate gender-specific body image in the brain:

How the brain constructs one’s inner sense of gender identity is poorly understood. On the other hand, the phenomenon of phantom sensations — the feeling of still having a body-part after amputation — has been much studied. Around 60% of men experience a phantom penis post-penectomy. As transsexuals report a mismatch between their inner gender identity and that of their body, we wondered what could be learned from this regarding innate gender-specific body image. We surveyed male-to-female transsexuals regarding the incidence of phantoms post-gender reassignment surgery. Additionally, we asked female-to-male transsexuals if they had ever had the sensation of having a penis when there was not one physically there. In post-operative male-to-female transsexuals the incidence of phantom penises was significantly reduced at 30%. Remarkably, over 60% of female-to-male transsexuals also reported phantom penises. We explain the absence/presence of phantoms here by postulating a mismatch between the brain’s hardwired gender-specific body image and the external somatic gender. Further studies along these lines may provide penetrating insights into the question of how nature and nurture interact to produce our brain-based body image.

Simon LeVay, an expert on human sexuality, does make the point that Ramachandran is comparing those who are extremely pleased with getting rid of their penis to others who are distressed and think about their penis all the time. It would appear that Ramachandran has largely left out emotions, and also the question of wishful thinking.

MindBlog's editorial assistant

It is very difficult to putter with this blog while lounging on my couch - one of my new Abyssianian kittens always helps out or wishes I would play with him instead.

A simple metric to infer personality from facial expression

Oosterhof and Todorov have devised a simple model that uses facial cues that have evolutionary significance to predict important social judgments as a function of two orthogonal dimensions of valence and dominance. Here is a graphic illustrating the essential facial features, followed by their abstract.

People automatically evaluate faces on multiple trait dimensions, and these evaluations predict important social outcomes, ranging from electoral success to sentencing decisions. Based on behavioral studies and computer modeling, we develop a 2D model of face evaluation. First, using a principal components analysis of trait judgments of emotionally neutral faces, we identify two orthogonal dimensions, valence and dominance, that are sufficient to describe face evaluation and show that these dimensions can be approximated by judgments of trustworthiness and dominance. Second, using a data-driven statistical model for face representation, we build and validate models for representing face trustworthiness and face dominance. Third, using these models, we show that, whereas valence evaluation is more sensitive to features resembling expressions signaling whether the person should be avoided or approached, dominance evaluation is more sensitive to features signaling physical strength/weakness. Fourth, we show that important social judgments, such as threat, can be reproduced as a function of the two orthogonal dimensions of valence and dominance. The findings suggest that face evaluation involves an overgeneralization of adaptive mechanisms for inferring harmful intentions and the ability to cause harm and can account for rapid, yet not necessarily accurate, judgments from faces.

Weekly musical offering - Stars & Stripes FOREVER!

Brain changes that correlate with successful dyslexia therapy

Meyler et al. have published an interesting study in Neuropsychologia showing brain plasticity during the remedial instruction of poor readers:

This study used fMRI to longitudinally assess the impact of intensive remedial instruction on cortical activation among 5th grade poor readers during a sentence comprehension task. The children were tested at three time points: prior to remediation, after 100 h of intensive instruction, and 1 year after the instruction had ended. Changes in brain activation were also measured among 5th grade good readers at the same time points for comparison. The central finding was that prior to instruction, the poor readers had significantly less activation than good readers bilaterally in the parietal cortex. Immediately after instruction, poor readers made substantial gains in reading ability, and demonstrated significantly increased activation in the left angular gyrus and the left superior parietal lobule. Activation in these regions continued to increase among poor readers 1 year post-remediation, resulting in a normalization of the activation. These results are interpreted as reflecting changes in the processes involved in word-level and sentence-level assembly. Areas of overactivation were also found among poor readers in the medial frontal cortex, possibly indicating a more effortful and attentionally guided reading strategy.


Brain areas showing greater activation among good readers vs. poor readers at each phase of the study. The same data are presented overlaid on a surface rendering (right column) and overlaid on individual coronal slices (left column) of the normalized Montreal Neurological Institute canonical brain. Yellow ovals encircle parietal activation.

Cat Pols

My apologies, I can't help myself. Another cat video.. click on this link, not the picture below.

Oxytocin attenuates aversive reactions

Here is an interesting report from Dolan's laboratory, showing that oxytocin attenuates our emotional response and amygdala reactivity to faces that we have learned to dislike (enter oxytocin in the 'search MindBlog' box in the left column to note previous postings on oxytocin).

Social relations between humans critically depend on our affective experiences of others. Oxytocin enhances prosocial behavior, but its effect on humans' affective experience of others is not known. We tested whether oxytocin influences affective ratings, and underlying brain activity, of faces that have been aversively conditioned. Using a standard conditioning procedure, we induced differential negative affective ratings in faces exposed to an aversive conditioning compared with nonconditioning manipulation. This differential negative evaluative effect was abolished by treatment with oxytocin, an effect associated with an attenuation of activity in anterior medial temporal and anterior cingulate cortices. In amygdala and fusiform gyrus, this modulation was stronger for faces with direct gaze, relative to averted gaze, consistent with a relative specificity for socially relevant cues. The data suggest that oxytocin modulates the expression of evaluative conditioning for socially relevant faces via influences on amygdala and fusiform gyrus, an effect that may explain its prosocial effects.

Self interest versus the common good in economic policy design.

An essay by Bowles in Science points to a shortcoming in the conventional economic approach to policy design: It overlooks the possibility that economic incentives (i.e. those appealing to self-regarding preferences) may diminish ethical or other reasons for complying with social norms and contributing to the common good. Where this is the case, the kinds of incentives stressed by economists may have counterproductive effects.

Diego Rivera's mural of factory workers at Ford's River Rouge assembly plant (detail). Modern economies require cooperation toward common ends among countless individuals, often occurring as the result of both self-interested and ethical motives. Recent behavioral experiments show that organizational strategies may backfire if they rely solely on explicit economic incentives and seek to limit the options of group members.

One interesting real-life experiment:

In Haifa, at six day care centers, a fine was imposed on parents who were late picking up their children at the end of the day. Parents responded to the fine by doubling the fraction of time they arrived late. When after 12 weeks the fine was revoked, their enhanced tardiness persisted unabated. While other interpretations are possible, the counterproductive imposition of the fines illustrate a kind of negative synergy between economic incentives and moral behavior. The fine seems to have undermined the parents' sense of ethical obligation to avoid inconveniencing the teachers and led them to think of lateness as just another commodity they could purchase.

Here is the abstract of the article:

High-performance organizations and economies work on the basis not only of material interests but also of Adam Smith's "moral sentiments." Well-designed laws and public policies can harness self-interest for the common good. However, incentives that appeal to self-interest may fail when they undermine the moral values that lead people to act altruistically or in other public-spirited ways. Behavioral experiments reviewed here suggest that economic incentives may be counterproductive when they signal that selfishness is an appropriate response; constitute a learning environment through which over time people come to adopt more self-interested motivations; compromise the individual's sense of self-determination and thereby degrade intrinsic motivations; or convey a message of distrust, disrespect, and unfair intent. Many of these unintended effects of incentives occur because people act not only to acquire economic goods and services but also to constitute themselves as dignified, autonomous, and moral individuals. Good organizational and institutional design can channel the material interests for the achievement of social goals while also enhancing the contribution of the moral sentiments to the same ends.

And here is the PDF.

Cute Cat Overload on the Web

Several days ago my daughter sent me this link to a site of humorous cat pictures such as the following.













Now in today's New York Times I see an article by Dan Mitchell on other warm, cuddly, and fuzzy sites. An excerpt:

Meg Frost, a 36-year-old design manager at Apple, started cuteoverload.com three years ago to test Web software. Within months, it became an online institution, drawing about 88,000 unique visitors a day...viewing the site “is like taking a happy pill.”

And in that warm feeling lies the reason for its popularity. Given all the nastiness on the Internet — blog trolls, flame wars, vicious gossip, pornography, snark and spam — what better antidote is there than looking at pictures of tiny ducklings waddling in a line or kittens splayed on their backs, paw pads in the air?

The most famous cute-animal Web sites are presented with a touch of self-mockery. The site I Can Has Cheezburger? (icanhascheezburger.com) features cat pictures with ungrammatical captions, Stuff on My Cat (stuffonmycat.com) displays photos of objects stacked on sleeping cats, and Kittenwars.com pits pairs of cat photos in a cuteness showdown.

Brain Correlates of Borderline Personality Disorder

King-Casas et al. carry out interesting experiments in which they recruited 55 individuals afflicted with borderline personality disorder (BPD) to play a multiround economic exchange game with healthy partners. Imaging experiments were also performed that revealed different patterns of insula activation in BPD subjects. Here is the abstract, followed by a figure from an accompanying review by Meyer-Lindenberg.

To sustain or repair cooperation during a social exchange, adaptive creatures must understand social gestures and the consequences when shared expectations about fair exchange are violated by accident or intent. We recruited 55 individuals afflicted with borderline personality disorder (BPD) to play a multiround economic exchange game with healthy partners. Behaviorally, individuals with BPD showed a profound incapacity to maintain cooperation, and were impaired in their ability to repair broken cooperation on the basis of a quantitative measure of coaxing. Neurally, activity in the anterior insula, a region known to respond to norm violations across affective, interoceptive, economic, and social dimensions, strongly differentiated healthy participants from individuals with BPD. Healthy subjects showed a strong linear relation between anterior insula response and both magnitude of monetary offer received from their partner (input) and the amount of money repaid to their partner (output). In stark contrast, activity in the anterior insula of BPD participants was related only to the magnitude of repayment sent back to their partner (output), not to the magnitude of offers received (input). These neural and behavioral data suggest that norms used in perception of social gestures are pathologically perturbed or missing altogether among individuals with BPD. This game-theoretic approach to psychopathology may open doors to new ways of characterizing and studying a range of mental illnesses.


(Click to enlarge). Activation of the anterior insula is observed during an economic trust game in individuals with borderline personality disorder and healthy controls. Both groups show higher activation in response to stingy repayments they are about to make. However, only players with the disorder have no differential response to low offers from an investor (upper left graph), indicating that they lack the "gut feeling" that the relationship (cooperation) is in jeopardy.

Our expressions of fear and disgust serve specific adaptive purposes

Susskind et al. make some interesting observations that suggest that our facial expressions of fear or disgust are not set by arbitrary social conventions but rather have an evolved Darwinian basis. From Whalen and Kleck's review of this work of this work in the same issue of Nature Neuroscience:

...when subjects posed fearful faces, they were able to detect more flashes of light in the upper extent of their peripheral visual field, they were faster to move their eyes to targets in their visual field and they took in more air through the nose. In contrast, when they posed disgusted expressions, they detected fewer flashes of light in the upper extent of their visual field, they were slower to move their eyes to visual targets and they took in less air through the nose. Thus, the converse movements of the brows, eyelids and nose enacted in the formation of these expressions had opposite effects on sensory intake (see figure). This makes sense when one considers the situations where these expressions are encountered. Fearful expressions are observed at times when you would do well to learn more about your surroundings and disgusted expressions are observed at times when you feel you have learned quite enough.


Note how the various parts of the face move in opposite directions in the two expressions, and therefore have opposite effects on sensory intake.

That eye widening should facilitate environmental monitoring is consistent with other data showing that the amygdala has a unique relationship with fearful facial expressions. Indeed, the amygdala uses the widened eyes in fearful expressions as a proxy for the presence of fearful faces, and lesions of the human amygdala result in an inability to properly scan the eye whites in fearful faces. Further, electrical stimulation of the human amygdala results in eye widening and heightened visual scanning of the environment and produces nonspecific arousal responses such as pupil dilation. Neuroimaging studies have shown that the amygdala is sensitive to the pupil size of others. Taken together, these findings support the hypothesized role of the amygdala in potentiating sensory information processing to facilitate learning about the predi. More generally, these results suggest that your amygdala is sensitive to the very facial responses in others that it controls in you.

If the amygdala has shown an affinity for the facial expression of fear, then the analogous brain region for disgusted expressions would be the insular cortex. Neuroimaging, as well as depth electrode recording studies, show that human insular cortex responds to disgusted faces, and damage to the insula produces deficits in the recognition of disgusted faces11. Furthermore, insular pathology in Huntington's disorder is associated with a decreased disgust response and a similar recognition deficit of disgust. Although it is tempting to divide duties for the amygdala and insular cortex between fear and disgust and to suggest that they represent unique neural substrates for their processing, other work suggests that these reciprocally connected regions will interact along dimensions such as arousal, valence and/or attention, dimensions that cross the stark boundary between these two expression categories.

Mindblog does an experiment with resveratrol, the anti-aging compound.

I have done a number of posts on resveratrol (to have a look at them, enter 'resveratrol' in the search box in the left column). This compound appears to mimic the effects of caloric restriction in some animals, and in some cases extends lifespans. It has effects on enzyme profiles that resemble those caused by exercise. With some hesitation, I decided to do a self-experiment, taking the compound for several weeks to see if I noted any steady state changes in physiology, energy, temperament, etc. and then stopping the supplement to observe whether any changes I noted went away. (Goggling away on the web, you find a large number of sites, having almost the aura of cults, claiming wondrous properties of this new magic molecule.)

If you don't feel like reading through the whole account below, the bottom line is that after noting some positive, but transient, positive changes in energy and temperament, the appearance of arthritic symptoms led me to terminate the self-experiment. The arthritic symptoms then disappeared. (Added note, in response to immediate input from a reader of this post: Resveratrol is an anti-TNF (tumor necrosis factor) agent and in some instances this may trigger autoimmune symptoms.)

The hesitation to start this experiment derived from my experience when I tried this in 2004. Then, as now, I used resveratrol obtained from Now Foods, pills containing 400 mg of a root extract that claims to contain 200 mg resveratrol. After a few weeks I noted that my hands were becoming stiff, finger joints were starting to 'click' , i.e. arthritic symptoms. I freaked out, stopped the resveratrol, and started taking glucose amine, chondroitin sulfate, MSM, Calcium, Magnesium. The arthritis went away over the next week or two, but of course I didn't know whether to attribute that to stopping the resveratrol, starting the latter supplements, or placebo effect.

So, this time I started 200 mg with breakfast, tried to stay very flat and objective in my observations, especially attentive to any negative effects. (I tried in vain to find in the literature, on the web, any reported negative side effects reported by people taking resveratrol.) On day 11, I started another 200 mg with dinner.

On day 13, I decided to write down a number of effects, fairly subtle, but quite clear. (I had been looking mainly for negative symptoms, and so required the following observations to be clear and sustained, noticed as facts, not goals, with changes clearly different from the previous period in a sustained way. My food intake and level of formal exercise (gym) activity had not changed significantly.)

-more constant energy in just moving through a day, from one activity to another… (While running at gym, I didn't begin to slow down after the first mile).
-an absence of mildly negative, curmudgeonly, temperament, the temperament being now more flat to positive.
-more sexual energy (I check the web: resveratrol inhibitis the esterase that breaks down testosterone)
-a bit more spontaneous emotional reactivity, to memories, things in the environment,
-the daily weight range (lowest on waking in the a.m. then plus a few pounds by gym weighing) may have shifted down 1-2 pounds

By day 15 I'm deciding I don’t think the weight range has changed significantly. Further, over a period of just a few days, everything seems to return to where it was, as if physiological and temperamental homeostatic mechanisms had noted a 'perturbation' and so were returning the body to its normal set-points. On day 16 I sign off on thinking that the positive effects reported above are long term. I also realize that hand stiffness has been increasing over the past few days, finger joints have started clicking. (These observations seem to be contrary to several reports that resveratrol inhibits enzymes (COX-1 and COX-2) involved in inflammatory arthritic responses.)

I continue to take the 400 mg of daily resveratrol for two more days, note increasing arthritic symptoms, and discontinue on day. 19. Over the next week, the stiffness and clicking joints disappear, and hand movements become supple again.

So, that is it. Deric's experiment was finished. Don't think I'm going to go there again.