Gratitude reduces economic impatience.

Whenever I come across yet another self-help laundry list of useful tricks for feeling better, and try a few, I repeatedly find that briefly following instructions to practice feeling gratitude has a very salutary, calming, effect...taking the edge off any impatience I might be feeling. DeSteno et al. look at this in a more systematic way, distinguishing the effect of gratitude from more positive global emotions of happiness with respect impatience, or short-term gratification. 75 study participants were split in three groups with different emotion-induction conditions: being asked to write brief essays on experiences of feeling grateful, happy, or neutral. They then made choices between receiving smaller cash amounts (ranging from $11 to $80) immediately and larger cash amounts (ranging from $25 to $85) at a point from 1 week to 6 months in the future. Their results clearly revealed that gratitude reduces excessive economic impatience (the temporal discounting of future versus immediate rewards) compared with the neutral and happy conditions, which were about equal. Here is their abstract:

The human mind tends to excessively discount the value of delayed rewards relative to immediate ones, and it is thought that “hot” affective processes drive desires for short-term gratification. Supporting this view, recent findings demonstrate that sadness exacerbates financial impatience even when the sadness is unrelated to the economic decision at hand. Such findings might reinforce the view that emotions must always be suppressed to combat impatience. But if emotions serve adaptive functions, then certain emotions might be capable of reducing excessive impatience for delayed rewards. We found evidence supporting this alternative view. Specifically, we found that (a) the emotion gratitude reduces impatience even when real money is at stake, and (b) the effects of gratitude are differentiable from those of the more general positive state of happiness. These findings challenge the view that individuals must tamp down affective responses through effortful self-regulation to reach more patient and adaptive economic decisions.

Childhood bullying predicts adult inflammation.

How is this for a chilling finding? Childhood bullying leaves bullies with lower, and victims with higher, levels of chronic inflammation than those uninvolved in bullying. From Copeland et al. :

Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one’s status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ill effects. The aim of this study is to test how this adverse social experience is biologically embedded to affect short- or long-term levels of C-reactive protein (CRP), a marker of low-grade systemic inflammation. The prospective population-based Great Smoky Mountains Study (n = 1,420), with up to nine waves of data per subject, was used, covering childhood/adolescence (ages 9–16) and young adulthood (ages 19 and 21). Structured interviews were used to assess bullying involvement and relevant covariates at all childhood/adolescent observations. Blood spots were collected at each observation and assayed for CRP levels. During childhood and adolescence, the number of waves at which the child was bullied predicted increasing levels of CRP. Although CRP levels rose for all participants from childhood into adulthood, being bullied predicted greater increases in CRP levels, whereas bullying others predicted lower increases in CRP compared with those uninvolved in bullying. This pattern was robust, controlling for body mass index, substance use, physical and mental health status, and exposures to other childhood psychosocial adversities. A child’s role in bullying may serve as either a risk or a protective factor for adult low-grade inflammation, independent of other factors. Inflammation is a physiological response that mediates the effects of both social adversity and dominance on decreases in health.

Added note: I just came across this related article by Raposa et. al. on the developmental pathway from early life stress to inflammation.

Tonics for a long life?

I've recently come across two articles relevant to life extension (work done with mice and worms, to be sure, but a human who reads these papers might well be trying to get their hands on some of the stuff described to give it a try!). Dubai et al. report their work on Klotho, an aging regulator that, when overexpressed, extends lifespan in mice and nematode worms, and, when disrupted, accelerates aging phenotypes. (A lifespan expanding human variant of the KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers.) Here is their summary:

Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers. Because this allele increased klotho levels in serum, we analyzed transgenic mice with systemic overexpression of klotho. They performed better than controls in multiple tests of learning and memory. Elevating klotho in mice also enhanced long-term potentiation, a form of synaptic plasticity, and enriched synaptic GluN2B, an N-methyl-D-aspartate receptor (NMDAR) subunit with key functions in learning and memory. Blockade of GluN2B abolished klotho-mediated effects. Surprisingly, klotho effects were evident also in young mice and did not correlate with age in humans, suggesting independence from the aging process. Augmenting klotho or its effects may enhance cognition and counteract cognitive deficits at different life stages.

And, Ye et al. have done a screen, using nematodes, of over 1200 drugs active on human cells, including drugs approved for human use, finding ~60 that increase C. elegans lifespan up to 43%. They mainly act on proteins that function in signaling pathways between cells relevant to oxidative stress resistance - hormone or neurotransmitter receptors, particularly those for adrenaline and noradrenaline, serotonin, dopamine, histamine, and serotonin. This suggests and narrows down a list of drugs that might be tested for life extension in mammals.

One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To investigate this question, we screened a library of compounds with known mammalian pharmacology for compounds that increase C. elegans lifespan. We identified 60 compounds that increase longevity in C. elegans, 33 of which also increased resistance to oxidative stress. Many of these compounds are drugs approved for human use. Enhanced resistance to oxidative stress was associated primarily with compounds that target receptors for biogenic amines, such as dopamine or serotonin. A pharmacological network constructed with these data reveal that lifespan extension and increased stress resistance cluster together in a few pharmacological classes, most involved in intercellular signaling. These studies identify compounds that can now be explored for beneficial effects on aging in mammals, as well as tools that can be used to further investigate the mechanisms underlying aging in C. elegans.

Rapidity of human brain and muscle evolution - the downside of smarts?

Roberts does a summary of fascinating work by Bozak et al. He sets the context: 

Somewhat narcissistically, one of the spectacular changes in phenotype that we tend to be most interested in is the enhancement in our own brain power which has occurred over the 6 million years that separate us from our last shared ancestor with chimpanzees. The chimp genome is famously very similar to our own, but the technological, linguistic, and cultural phenotype is clearly profoundly different. Several studies have asked open-ended questions as to what happens between the genotype and phenotype to make us so different from our cousins, finding differences in levels, splicing, and editing of gene transcripts, for example. Now a paper just published in PLOS Biology by Katarzyna Bozek, Philipp Khaitovich, and colleagues looks at another intermediate phenotype—the metabolome—with some intriguing and unexpected answers...The metabolome is the set of small molecules (metabolites) that are found in a given tissue; by “small” we mean those with a molecular weight of less than 1,500 Daltons, which includes fats, amino acids, sugars, nucleotides, and vitamins (vitamin B12, for example, is near the top end of this range).  

...the metabolomes of human prefrontal cortex (and of combined brain regions) have changed four times as rapidly in the last 6 million years as those of chimps. While gratifying, this largely confirms for metabolites what was already known for transcripts. 

...brain is not the most spectacular outlier here. The real surprise is that the human muscle metabolome has experienced more than eight times as much change as its chimp counterpart. Indeed, metabolomically speaking, human muscle has changed more in the last 6 million years than mouse muscle has since we parted company from mice back in the Early Cretaceous.  

...the authors compared the performance of humans, chimps, and macaques in a strength test that involved pulling a handle to raise a weight. Human strength, as measured by this test, was barely half that of the non-human primates. Amazingly, untrained chimps and macaques raised in captivity easily outperformed university-level basketball players and professional mountain climbers. The authors speculate that the fates of human brain and muscle may be inextricably entwined, and that weak muscle may be the price we pay for the metabolic demands of our amazing cognitive powers.

A Monday musical offering - Poulenc Improvisation No. 7

This is recorded on the Steinway B at my Twin Valley Rd. residence in Middleton, WI.  I used to regularly post my piano work on MindBlog, and will try to return to the habit.

First direct evidence for human sex pheromones.

Here is a clever experiment by Zhou et al., who digitally morph the gender of moving point light displays of walking from male to female while subjects are exposed to two human steroids that they can not discriminate. Here is their summary and abstract:

•Human steroid androstadienone conveys masculinity to straight women and gay men
•Human steroid estratetraenol conveys femininity to straight men
•The effects take place in the absence of awareness
•Human gender perception draws on subconscious chemosensory biological cues

Recent studies have suggested the existence of human sex pheromones, with particular interest in two human steroids: androstadienone (androsta-4,16,-dien-3-one) and estratetraenol (estra-1,3,5(10),16-tetraen-3-ol). The current study takes a critical step to test the qualification of the two steroids as sex pheromones by examining whether they communicate gender information in a sex-specific manner. By using dynamic point-light displays that portray the gaits of walkers whose gender is digitally morphed from male to female, we show that smelling androstadienone systematically biases heterosexual females, but not males, toward perceiving the walkers as more masculine. By contrast, smelling estratetraenol systematically biases heterosexual males, but not females, toward perceiving the walkers as more feminine. Homosexual males exhibit a response pattern akin to that of heterosexual females, whereas bisexual or homosexual females fall in between heterosexual males and females. These effects are obtained despite that the olfactory stimuli are not explicitly discriminable. The results provide the first direct evidence that the two human steroids communicate opposite gender information that is differentially effective to the two sex groups based on their sexual orientation. Moreover, they demonstrate that human visual gender perception draws on subconscious chemosensory biological cues, an effect that has been hitherto unsuspected.

Social attention and our ventromedial prefrontal cortex.

Ralph Adolphs points to an interesting article by Wolf et al. showing that bilateral ventromedial prefrontal cortex damage impairs visual attention to the eye regions of faces, particularly for fearful faces. From Adolphs summary:

Failing to look at the eyes. Shown in each image are the regions of a face at which different groups of subjects look, as measured using eye-tracking. The hottest colours (red regions) denote those regions of the face where people look the most. Whereas this corresponds to the eye region of the face in healthy controls (far left), it is abnormal in certain clinical populations, including individuals with lesions of the vmPFC (top right) or amygdala (bottom right) and individuals with autism spectrum disorder (bottom centre) Top row: from Wolf et al. 2014. Bottom row: data from Michael Spezio, Daniel Kennedy, Ralph Adolphs. All images represent spatially smoothed data averaged across multiple fixations, multiple stimuli and multiple subjects within the indicated group.

Blue Mind - looking at water improves your health and calm

I just spend three days this past weekend in a guesthouse cabin in Door County, Wisconsin - three days of seeing mainly gorgeous green forests and the blue expanses of Lake Michigan on both sides of the Door County peninsula. Over those days, just looking at the water, I could feel a calm growing that quieted my normally chattering mind. Now, back in my university office, what do I stumble across but an article (on stress) that mentions this calming effect of water, a review by Michael Gross titled "Chronic stress means we’re always on the hunt", which first notes that one relief described for chronic stress (dubbed "Red Mind") is to give the stress system some real exercise (doing something like sky diving) to put the more mundane stresses of daily life in perspective. But then, in a second portion of his article, he points to work of Wallace J. Nichols and others who use the phrase "Blue mind" to describe the interface between our psychology and natural environment, particularly water, the largest feature of that environment. Gross notes that Nichols has put his ideas

...in a new book, called Blue Mind: How Water Makes You Happier, More Connected, and Better at What You Do, which is due to appear in June. In his book, Nichols discusses a spate of recent psychology papers showing that the proximity of “blue nature” can improve people’s physical and mental health and counterbalance the damaging effects of the chronic stress and the permanent engagement of the red mind. While the opportunity to exercise plays a part, several studies have shown that the positive effect of being near water can be separated from that aspect.

Crowdsourcing our brain’s wiring.

You too can be be a neuroscientist! I have to join in the general chorus of press pointing to the efforts of Sebastian Seung, now moving from MIT to Princeton Univ. Detailed analysis of serial ultra-thin electron microscope sections of brain neurons is extremely laborious - tracing one cells takes about 50 hours. Seung has asked for help from the general public ("citizen neuroscientists") in doing this with neurons in the mouse retina. The data on how bipolar cells connect to amacrine motion detecting cells in the retina has suggested a model for motion detection. This animation of their results is a treat to watch:

The science of inequality.

The May 23 issue of Science Magazine has a large section devoted the origins and analysis of economic inequality. And, the general gist of virtually all the articles is that inequality is here to stay, predicted by social and also simple physical models of exchange. A weekly chaos and complexity discussion group that I attend just this past Tuesday discussed the economic Yard-Sale Model of wealth redistribution, in which power-law-like distributions result even when all individuals are identical and playing by the same rules. In a previous post, I have passed on a simple model illustrated by Clint Sprott, organizer of the seminars.

The monkey business illusion.

Many people have by now viewed the famous "Gorilla Video" made by Daniel Simons over fifteen years ago, in which most viewers asked to count how many times students are passing a basketball to each other completely miss the fact that a gorilla walks through the middle of the scene halfway through the exercise. I'm passing on Simons' update of his original demonstration, which shows further how we see what we want or expect to see. It has been viewed over 4 million times, and gives links to his other work and publications. (The video is public on youtube, but copyrighted, so I hope Mr. Simons doesn't mind this advertisement for his work.)

 

How social equality is represented in the brain.

Interesting work from Aoki, Adolphs, and collaborators:

A distinct aspect of the sense of fairness in humans is that we care not only about equality in material rewards but also about equality in nonmaterial values. One such value is the opportunity to choose freely among many options, often regarded as a fundamental right to economic freedom. In modern developed societies, equal opportunities in work, living, and lifestyle are enforced by antidiscrimination laws. Despite the widespread endorsement of equal opportunity, no studies have explored how people assign value to it. We used functional magnetic resonance imaging to identify the neural substrates for subjective valuation of equality in choice opportunity. Participants performed a two-person choice task in which the number of choices available was varied across trials independently of choice outcomes. By using this procedure, we manipulated the degree of equality in choice opportunity between players and dissociated it from the value of reward outcomes and their equality. We found that activation in the ventromedial prefrontal cortex (vmPFC) tracked the degree to which the number of options between the two players was equal. In contrast, activation in the ventral striatum tracked the number of options available to participants themselves but not the equality between players. Our results demonstrate that the vmPFC, a key brain region previously implicated in the processing of social values, is also involved in valuation of equality in choice opportunity between individuals. These findings may provide valuable insight into the human ability to value equal opportunity, a characteristic long emphasized in politics, economics, and philosophy.

Note: The same issue of Journal of Neuroscience has a related article by Matthew Apps and Ramnani showing that activity in the anterior cingulate gyrus covaries with the net value of rewards that someone else will receive when that person is required to exert effort for the reward.

Brain correlates of expertise in musical improvisation

Pihno et al. show that expertise in musical improvisation is associated with increased connectivity between premotor and prefrontal areas, suggesting that the ability to produce novel output can be automated by training:

Musicians have been used extensively to study neural correlates of long-term practice, but no studies have investigated the specific effects of training musical creativity. Here, we used human functional MRI to measure brain activity during improvisation in a sample of 39 professional pianists with varying backgrounds in classical and jazz piano playing. We found total hours of improvisation experience to be negatively associated with activity in frontoparietal executive cortical areas. In contrast, improvisation training was positively associated with functional connectivity of the bilateral dorsolateral prefrontal cortices, dorsal premotor cortices, and presupplementary areas. The effects were significant when controlling for hours of classical piano practice and age. These results indicate that even neural mechanisms involved in creative behaviors, which require a flexible online generation of novel and meaningful output, can be automated by training. Second, improvisational musical training can influence functional brain properties at a network level. We show that the greater functional connectivity seen in experienced improvisers may reflect a more efficient exchange of information within associative networks of importance for musical creativity.

Brain correlates of "the good life" ??

Lewis et al. offer another example of the class of experiments correlating the volume of a specific brain area with a specific behavior, in this case eudaimonic well-being, which is positively correlated with volume in the right insular cortex. Eudaimonia is fundamentally linked to notions of agency, and recent work has identified insular cortex as a source of agentic control. The insula has also been linked to facilitation of self-awareness, as well as to the regulation of bodily states and modulation of decision making based on interoceptive information about these bodily states.

Whether the behavior causes the larger insular volume or vice versa can’t be determined. These particular experiments did not control for simple subjective (hedonic) well-being, so the observed volume increase in the insula may not be a unique correlate of eudaimonia. Here is their abstract, and the entire text of the article is open source.

Eudaimonic well-being reflects traits concerned with personal growth, self-acceptance, purpose in life and autonomy (among others) and is a substantial predictor of life events, including health. Although interest in the aetiology of eudaimonic well-being has blossomed in recent years, little is known of the underlying neural substrates of this construct. To address this gap in our knowledge, here we examined whether regional gray matter (GM) volume was associated with eudaimonic well-being. Structural magnetic resonance images from 70 young, healthy adults who also completed Ryff’s 42-item measure of the six core facets of eudaimonia, were analysed with voxel-based morphometry techniques. We found that eudaimonic well-being was positively associated with right insular cortex GM volume. This association was also reflected in three of the sub-scales of eudaimonia: personal growth, positive relations and purpose in life. Positive relations also showed a significant association with left insula volume. No other significant associations were observed, although personal growth was marginally associated with left insula, and purpose in life exhibited a marginally significant negative association with middle temporal gyrus GM volume. These findings are the first to our knowledge linking eudaimonic well-being with regional brain structure.

Stress can protect from Alzheimer's disease

Yanker and his collaborators have found that levels of a neuro-protective protein called REST (repressor element 1-silencing transcription factor) are increased in the brain by any form of cellular stress (oxidative, immune, etc.) It acts by repressing genes involved in cell death and Alzheimer's dementia. REST levels in prefrontal cortical neurons are positively correlated with a measure of global cognition, and also separate measures of episodic, semantic and working memory. Measurements of autopsied brains of elderly people who have died of Alzheimer's are three times lower than in the brains of people the same age without dementia. Here is their abstract:

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons. REST is lost, however, in mild cognitive impairment and Alzheimer’s disease. Chromatin immunoprecipitation with deep sequencing and expression analysis show that REST represses genes that promote cell death and Alzheimer’s disease pathology, and induces the expression of stress response genes. Moreover, REST potently protects neurons from oxidative stress and amyloid β-protein toxicity, and conditional deletion of REST in the mouse brain leads to age-related neurodegeneration. A functional orthologue of REST, Caenorhabditis elegans SPR-4, also protects against oxidative stress and amyloid β-protein toxicity. During normal ageing, REST is induced in part by cell non-autonomous Wnt signalling. However, in Alzheimer’s disease, frontotemporal dementia and dementia with Lewy bodies, REST is lost from the nucleus and appears in autophagosomes together with pathological misfolded proteins. Finally, REST levels during ageing are closely correlated with cognitive preservation and longevity. Thus, the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing brain.

Fear detection depends on phase of our heartbeats.

Here's a fascinating piece of work:

Cognitions and emotions can be influenced by bodily physiology. Here, we investigated whether the processing of brief fear stimuli is selectively gated by their timing in relation to individual heartbeats. Emotional and neutral faces were presented to human volunteers at cardiac systole, when ejection of blood from the heart causes arterial baroreceptors to signal centrally the strength and timing of each heartbeat, and at diastole, the period between heartbeats when baroreceptors are quiescent. Participants performed behavioral and neuroimaging tasks to determine whether these interoceptive signals influence the detection of emotional stimuli at the threshold of conscious awareness and alter judgments of emotionality of fearful and neutral faces. Our results show that fearful faces were detected more easily and were rated as more intense at systole than at diastole. Correspondingly, amygdala responses were greater to fearful faces presented at systole relative to diastole. These novel findings highlight a major channel by which short-term interoceptive fluctuations enhance perceptual and evaluative processes specifically related to the processing of fear and threat and counter the view that baroreceptor afferent signaling is always inhibitory to sensory perception.

Correlation between prosocial behavior and computer game playing

Here's what seems to me a a slightly counter-intuitive result. Numerous studies have a noted a correlation between playing violent computer games and less prosocial behavior, and studies of games involving cooperation correlate with more prosocial behaviors. Most of these studies have observed behaviors immediately after palying the games. Mengel takes a more neutral approach and simply asks whether there is a correlation between average daily time spent playing any sort of computer game and prosocial behavior assayed with the Prisoner's dilemma game over 10 different periods, with participating students also reporting on their daily computer use. They find the average cooperation rate is positively correlated with the self-reported amount of time participants spend playing computer games. None of the other computer time use variables (including time spent on social media, browsing internet, working etc.) are significantly related to cooperation rates.  (So...either cooperative students are more likely to spend a lot of time on computer games, or computer games enhance cooperative behavior... or... neither of the above.)

What drives collective versus individualistic behaviors?

Talheim et al. offer a strikingly simple explanation for why collective versus individualistic behaviors may arise in a given cultural group. Rather than the usual comparison of Western and Asian cultures as a whole, they look at large-scale psychological differences with China, and find that they correlate with the different behavioral requirements of rice versus wheat agriculture:

Cross-cultural psychologists have mostly contrasted East Asia with the West. However, this study shows that there are major psychological differences within China. We propose that a history of farming rice makes cultures more interdependent, whereas farming wheat makes cultures more independent, and these agricultural legacies continue to affect people in the modern world. We tested 1162 Han Chinese participants in six sites and found that rice-growing southern China is more interdependent and holistic-thinking than the wheat-growing north. To control for confounds like climate, we tested people from neighboring counties along the rice-wheat border and found differences that were just as large. We also find that modernization and pathogen prevalence theories do not fit the data.

From Henrich's description of their methods:

To investigate the individualism and analytical thinking in participants from different agricultural regions in China, Talhelm et al. used three tests. They measured analytical thinking with a series of triads. Participants were given a target object, such as a rabbit, and asked which of two other objects it goes with. Analytic thinkers tend to match on categories, so rabbits and dogs go together. Holistic thinkers tend to match on relationships, so rabbits eat carrots. The authors also measured individualism in two ways. First, they asked participants to draw a sociogram, with labeled circles representing themselves and their friends. In this test, individualism is measured implicitly by how much bigger the “self” circle is relative to the average “friends” circle. Second, they assessed the nepotism (in-group loyalty) of participants by asking them about hypothetical scenarios in which they could reward or punish friends and strangers for helpful or harmful action.

Morality and perception speed

Here is an interesting nugget... We are more likely to see a word flashed for a very brief interval if it has moral valence. Words related to morality can be identified after a 40-millisecond peek, but nonmoral words needed an extra 10 ms of exposure. From Gantman and Bavel:

Highlights

• We examined whether moral concerns shape awareness of ambiguous stimuli.
• Participants saw moral and non-moral words in a lexical decision task.
• Moral and non-moral words were matched on length, and frequency in lexicon.
• Participants correctly identified moral words more frequently than non-moral words.
• This experiments suggest that moral values may shape perceptual awareness.

Abstract

People perceive religious and moral iconography in ambiguous objects, ranging from grilled cheese to bird feces. In the current research, we examined whether moral concerns can shape awareness of perceptually ambiguous stimuli. In three experiments, we presented masked moral and non-moral words around the threshold for conscious awareness as part of a lexical decision task. Participants correctly identified moral words more frequently than non-moral words—a phenomenon we term the moral pop-out effect. The moral pop-out effect was only evident when stimuli were presented at durations that made them perceptually ambiguous, but not when the stimuli were presented too quickly to perceive or slowly enough to easily perceive. The moral pop-out effect was not moderated by exposure to harm and cannot be explained by differences in arousal, valence, or extremity. Although most models of moral psychology assume the initial perception of moral stimuli, our research suggests that moral beliefs and values may shape perceptual awareness.

Sluggish cognitive tempo, a new diagnosis du jour?

The drug companies may be finding a new profit center, having maxed out their ability to push pills on the more than 6 million American children who have received a diagnosis of A.D.H.D. (attention deficit hyperactivity disorder, which in my son’s case was evaluated by a sane pediatric psychiatrist who wisely said “Chill, he’s just acting like a kid.”) The new syndrome, summarized by Schwartz, is called sluggish cognitive tempo and said to be characterized by lethargy, daydreaming and slow mental processing. It is the subject of the entire January issue of The Journal of Abnormal Child Psychology.

Papers have proposed that a recognition of sluggish cognitive tempo could help resolve some longstanding confusion about A.D.H.D., which despite having hyperactivity in its name includes about two million children who are not hyperactive, merely inattentive. Some researchers propose that about half of those children would be better classified as having sluggish cognitive tempo, with perhaps one million additional children, who do not meet A.D.H.D.’s criteria now, having the new disorder, too.

The syndrome is not well defined, and many researchers refuse to discuss it, or their financial interests in the condition’s acceptance.

The description I find most intriguing and plausible is of a syndrome that involves extreme mind wandering, perhaps of a brain that is chronically in the “default” mode (described in a number of MindBlog posts) and unable to (or unwilling or too lazy to) activate the “attentional” or goal oriented, direct experiential focus, task positive network appropriately.  (Think about the teenagers behind fast-food counters completely unable to do simple addition and subtraction!). The best therapy for this syndrome would seem to be cognitive or behavioral (i.e. "SHAPE UP!"), rather than another pill to pop.

Drug treatments of this or other behavioral syndromes such as depression have the risk of diminishing personal agency and responsibility, as Iarovici notes:

We walk a thinning line between diagnosing illness and teaching our youth to view any emotional upset as pathological. We need a greater focus on building resilience in emerging adults. We need more scientific studies — spanning years, not months — on the risks and benefits of maintenance treatment in emerging adults.