Friday, June 22, 2018

Brain EEG activity can predict who antidepressants will work on

Pizzagalli et al. have used electroencephalography (EEG) to look at the activation level of the rostral anterior cingulate cortex (ACC) in depressed patients. In an experiment involving 300 patients at four different sites (with randomized controls) they find that higher activity in this area correlates with a higher probability that treatment with the SSRI (selective serotonin re-uptake inhibitor) sertraline hydrochloride will be effective after an eight week course of treatment. The prediction of drug efficacy made with this approach is more reliable than current guessing using other clinical and demographic characteristics that also correlate with treatment outcomes.

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