Thursday, September 22, 2016

Treating trans-generational stress with probiotics...

There is considerable evidence that the effects of stress can be transmitted across multiple generations in rats and also humans. Studies suggest that such inheritance might be intergenerational (mating behavior, parenting, in utero effects, etc.) or transgenerational (e.g., germ-line epigenetic alteration).

Given that gastrointestinal disorders frequently occur alongside various forms of psychopathology, and that their prevalence is increased in populations exposed to early-life stress, Callaghan et al. have now done experiments on rats suggesting that stress-induced changes to gut microbiota may play a mechanistic role (via microbiota-gut-brain interactions) in the transmission of stress reactivity across generations, and that probiotics can ameliorate this effect.
Early-life adversity is a potent risk factor for mental-health disorders in exposed individuals, and effects of adversity are exhibited across generations. Such adversities are also associated with poor gastrointestinal outcomes. In addition, emerging evidence suggests that microbiota-gut-brain interactions may mediate the effects of early-life stress on psychological dysfunction. In the present study, we administered an early-life stressor (i.e., maternal separation) to infant male rats, and we investigated the effects of this stressor on conditioned aversive reactions in the rats’ subsequent infant male offspring. We demonstrated, for the first time, longer-lasting aversive associations and greater relapse after extinction in the offspring (F1 generation) of rats exposed to maternal separation (F0 generation), compared with the offspring of rats not exposed to maternal separation. These generational effects were reversed by probiotic supplementation, which was effective as both an active treatment when administered to infant F1 rats and as a prophylactic when administered to F0 fathers before conception (i.e., in fathers’ infancy). These findings have high clinical relevance in the identification of early-emerging putative risk phenotypes across generations and of potential therapies to ameliorate such generational effects.

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