Thursday, December 04, 2008

Resveratrol promotes repair of DNA breaks that occur on aging

Nicholas Wade reports on work of Sinclair and collaborators (reported in Cell) that sirtulin, an enzyme activated by the red wine compound resveratrol, promotes the repair of breaks in DNA that occur on aging. (Ten previous MindBlog posts on resveratrol can be retrieved by entering "resveratrol" in the search box in the left column.) Resveratrol has many different effects, only some of which are exerted through sirtuin. While some people have been taking resveratrol with no apparent side effects, Mindblog's self-experiment found it causing arthritic symptoms, and that experience was reported by several who commented on that post.


  1. The wonder ingredient in wine is resveratrol. Dr. David Sinclair, Associate Professor of Pathology and Co-Director of the
    Laboratories for the Biological Mechanisms of Aging at Harvard Medical School is the leader in research into the anti-aging
    properties of resveratrol. The current studies performed by Dr. Sinclair and many other researchers have shown great promise
    for resveratrol treating the diseases of aging. There are numerous articles that I have linked to at my website - - that document the findings for the potential health benefits in treating heart disease, cancer, diabetes, osteoporosis,
    obesity, and other diseases.
    Concerning supplements containing a high quality and potency of resveratrol that is necessary to achieve the dosage levels
    utilized in the lab tests, there is a new product called Vivix. Dr. Sinclair partnered with Shaklee Corporation, the number
    one natural nutrition company in the U.S. (, to produce a liquid resveratrol supplement
    that is 10 times stronger than resveratrol alone due to its patented formulation of polyphenols. Dr. Sinclair also serves on Shaklee’s Scientific Advisory Board (
    Oprah Winfrey and Dr. Oz are both users and promoters of Shaklee products and Oprah has featured Roger Barnett, Chairman and
    CEO of Shaklee (, on her show.
    So for a highly researched resveratrol supplement of exceptional quality, please visit - - to discover more about Vivix.

  2. I think that your advocacy of resveratrol-like compounds should always include a warning about possible negative side effects of the sort I have mentioned in previous blog postings.