Oxytocin both bonds and divides the sexes.

From Gao et al.:

Facilitation of social attraction and bonding by the evolutionarily conserved neuropeptide oxytocin is well-established in female mammals. However, accumulating behavioral evidence suggests that oxytocin may have evolved sex-specific functional roles in the domain of human social cognition. A critical question is how oxytocin differentially modulates neural processing of social information in men and women, leading to divergent behavioral responses. Here we show that intranasal oxytocin treatment produces sex- and valence-dependent increases in amygdala activation when women view individuals identified as praising others but in men those who criticize them. Women subsequently show increased liking for the faces of these individuals, whereas in men it is reduced. Thus, oxytocin may act differentially via the amygdala to enhance the salience of positive social attributes in women but negative ones in men. We hypothesize that oxytocin may have evolved different but complementary roles to help ensure successful reproduction by encouraging mothers to promote a prosocial rearing environment for offspring and fathers to protect against antisocial influences.

Placebo effects in brain training

Foroughi et al. address the question of whether our desire to become smarter may blind us to the role of placebo effects in brain training regimes. They found that few published articles on cognitive training provide details regarding participant recruitment... whether participants were recruited overtly [e.g., “sign up for a brain training study” ] or covertly [e.g., “did not inform subjects that they were participating in a training study”]. The authors:

...designed a procedure to intentionally induce a placebo effect via overt recruitment. Our recruitment targeted two populations of participants using different advertisements varying in the degree to which they evoked an expectation of cognitive improvement. Once participants self-selected into the two groups, they completed two pretraining fluid intelligence tests followed by 1 h of cognitive training and then completed two posttraining fluid intelligence tests on the following day. Two individual difference metrics regarding beliefs about cognition and intelligence were also collected as potential moderators. The researchers who interacted with participants were blind to the goal of the experiment and to the experimental condition. Aside from their means of recruitment, all participants completed identical cognitive-training experiments. All participants read and signed an informed consent form before beginning the experiment.

Here are their summaries:

Significance

Placebo effects pose problems for some intervention studies, particularly those with no clearly identified mechanism. Cognitive training falls into that category, and yet the role of placebos in cognitive interventions has not yet been critically evaluated. Here, we show clear evidence of placebo effects after a brief cognitive training routine that led to significant fluid intelligence gains. Our goal is to emphasize the importance of ruling out alternative explanations before attributing the effect to interventions. Based on our findings, we recommend that researchers account for placebo effects before claiming treatment effects.

Abstract

Although a large body of research shows that general cognitive ability is heritable and stable in young adults, there is recent evidence that fluid intelligence can be heightened with cognitive training. Many researchers, however, have questioned the methodology of the cognitive-training studies reporting improvements in fluid intelligence: specifically, the role of placebo effects. We designed a procedure to intentionally induce a placebo effect via overt recruitment in an effort to evaluate the role of placebo effects in fluid intelligence gains from cognitive training. Individuals who self-selected into the placebo group by responding to a suggestive flyer showed improvements after a single, 1-h session of cognitive training that equates to a 5- to 10-point increase on a standard IQ test. Controls responding to a nonsuggestive flyer showed no improvement. These findings provide an alternative explanation for effects observed in the cognitive-training literature and the brain-training industry, revealing the need to account for confounds in future research.

Consciousness is the brain messing with itself.

George Johnson does a nice summary of some current ideas on what consciousness is that were discussed at a recent symposium (live stream here) at The New York Academy of Sciences. He notes for example Graziano's ideas that I have previously reviewed on MindBlog:

Descartes’s notion of dualism — mind and body as separate things — has long receded from science. The challenge now is to explain how the inner world of consciousness arises from the flesh of the brain.

Michael Graziano, a neuroscientist at Princeton University, suggested to the audience that consciousness is a kind of con game the brain plays with itself. The brain is a computer that evolved to simulate the outside world. Among its internal models is a simulation of itself — a crude approximation of its own neurological processes... The result is an illusion. Instead of neurons and synapses, we sense a ghostly presence — a self — inside the head. But it’s all just data processing...“The machine mistakenly thinks it has magic inside it,” Dr. Graziano said. And it calls the magic consciousness.

It’s not the existence of this inner voice he finds mysterious. “The phenomenon to explain,” he said, “is why the brain, as a machine, insists it has this property that is nonphysical.”

Johnson notes other ideas aired at the symposium, such as "the centuries-old doctrine of panpsychism — the idea that consciousness is universal, existing as some kind of mind stuff inside molecules and atoms."

Insurance makes sellers of services dishonest.

This piece from Kerschbamer et al. really resonates with my experiences in Florida, scam central for health insurance fraud:

Honesty is a fundamental pillar for cooperation in human societies and thus for their economic welfare. However, humans do not always act in an honest way. Here, we examine how insurance coverage affects the degree of honesty in credence goods markets. Such markets are plagued by strong incentives for fraudulent behavior of sellers, resulting in estimated annual costs of billions of dollars to customers and the society as a whole. Prime examples of credence goods are all kinds of repair services, the provision of medical treatments, the sale of software programs, and the provision of taxi rides in unfamiliar cities. We examine in a natural field experiment how computer repair shops take advantage of customers’ insurance for repair costs. In a control treatment, the average repair price is about EUR 70, whereas the repair bill increases by more than 80% when the service provider is informed that an insurance would reimburse the bill. Our design allows decomposing the sources of this economically impressive difference, showing that it is mainly due to the overprovision of parts and overcharging of working time. A survey among repair shops shows that the higher bills are mainly ascribed to insured customers being less likely to be concerned about minimizing costs because a third party (the insurer) pays the bill. Overall, our results strongly suggest that insurance coverage greatly increases the extent of dishonesty in important sectors of the economy with potentially huge costs to customers and whole economies.

Who blames the victim?

Niemi and Young ask

What determines whether someone feels sympathy or scorn for the victim of a crime? Is it a function of political affiliation? Of gender? Of the nature of the crime? (If you are mugged on a midnight stroll through the park, some people will feel compassion for you, while others will admonish you for being there in the first place. If you are raped by an acquaintance after getting drunk at a party, some will be moved by your misfortune, while others will ask why you put yourself in such a situation.) Their experiments find that the critical factor lies in a particular set of moral values. Their experiments show that the more strongly you privilege loyalty, obedience and purity — as opposed to values such as care and fairness — the more likely you are to blame the victim.

The abstract:

Why do victims sometimes receive sympathy for their suffering and at other times scorn and blame? Here we show a powerful role for moral values in attitudes toward victims. We measured moral values associated with unconditionally prohibiting harm (“individualizing values”) versus moral values associated with prohibiting behavior that destabilizes groups and relationships (“binding values”: loyalty, obedience to authority, and purity). Increased endorsement of binding values predicted increased ratings of victims as contaminated (Studies 1-4); increased blame and responsibility attributed to victims, increased perceptions of victims’ (versus perpetrators’) behaviors as contributing to the outcome, and decreased focus on perpetrators (Studies 2-3). Patterns persisted controlling for politics, just world beliefs, and right-wing authoritarianism. Experimentally manipulating linguistic focus off of victims and onto perpetrators reduced victim blame. Both binding values and focus modulated victim blame through victim responsibility attributions. Findings indicate the important role of ideology in attitudes toward victims via effects on responsibility attribution.

Social support, stress, and the aging brain

Sherman et al. find that the volume of the amygdala in older adults (a center for stress responses) is positively correlated with stress and negatively correlated with social support, these two effects being apparently independent of each other.

Social support benefits health and well-being in older individuals, however the mechanism remains poorly understood. One proposal, the stress-buffering hypothesis states social support ‘buffers’ the effects of stress on health. Alternatively, the main effect hypothesis suggests social support independently promotes health. We examined the combined association of social support and stress on the aging brain. Forty healthy older adults completed stress questionnaires, a social network interview and structural MRI to investigate the amygdala-medial prefrontal cortex circuitry, which is implicated in social and emotional processing and negatively affected by stress. Social support was positively correlated with right medial prefrontal cortical thickness while amygdala volume was negatively associated with social support and positively related to stress. We examined whether the association between social support and amygdala volume varied across stress level. Stress and social support uniquely contribute to amygdala volume, which is consistent with the health benefits of social support being independent of stress.

Is Donald Trump's frontostriatal connectivity weakened?

Chester et al. find an interesting correlation between grandiose narcissism and the strength of connections between brain areas that process self-relevant stimuli (the medial prefrontal cortex) and reward (the ventral striatum):

Narcissism is characterized by the search for affirmation and admiration from others. Might this motivation to find external sources of acclaim exist to compensate for neurostructural deficits that link the self with reward? Greater structural connectivity between brain areas that process self-relevant stimuli (i.e. the medial prefrontal cortex) and reward (i.e. the ventral striatum) is associated with fundamentally positive self-views. We predicted that narcissism would be associated with less integrity of this frontostriatal pathway. We used diffusion tensor imaging to assess the frontostriatal structural connectivity among 50 healthy undergraduates (32 females, 18 males) who also completed a measure of grandiose narcissism. White matter integrity in the frontostriatal pathway was negatively associated with narcissism. Our findings, while purely correlational, suggest that narcissism arises, in part, from a neural disconnect between the self and reward. The exhibitionism and immodesty of narcissists may then be a regulatory strategy to compensate for this neural deficit.

A non-linguistic brain network for mathematics.

From Amalrica and Dehaene:

The origins of human abilities for mathematics are debated: Some theories suggest that they are founded upon evolutionarily ancient brain circuits for number and space and others that they are grounded in language competence. To evaluate what brain systems underlie higher mathematics, we scanned professional mathematicians and mathematically naive subjects of equal academic standing as they evaluated the truth of advanced mathematical and nonmathematical statements. In professional mathematicians only, mathematical statements, whether in algebra, analysis, topology or geometry, activated a reproducible set of bilateral frontal, Intraparietal, and ventrolateral temporal regions. Crucially, these activations spared areas related to language and to general-knowledge semantics. Rather, mathematical judgments were related to an amplification of brain activity at sites that are activated by numbers and formulas in nonmathematicians, with a corresponding reduction in nearby face responses. The evidence suggests that high-level mathematical expertise and basic number sense share common roots in a nonlinguistic brain circuit.

Turning out the vote.

Gilbert Chen summarizes work of Gerber et al.:

A key challenge for any political campaign is to get its voters to actually vote. Field experiments have demonstrated that canvassing and phone calls are more effective than direct mail; all of these interventions increase voter participation by 0.5 to as much as 3 percentage points. With this in mind, Gerber et al. have reexamined an intervention based on the theory that nouns describe more stable attributes than verbs; for instance, “I am a Republican” versus “I vote for Republicans.” They find, using 11,000 voters across three U.S. states, no difference between “noun” and “verb” phone calls and that neither message is as effective as referring to social norms in getting voters to the polls.

Endogenous opioids are not involved in meditation based pain relief

From Zeidan et al.:

Mindfulness meditation, a cognitive practice premised on sustaining nonjudgmental awareness of arising sensory events, reliably attenuates pain. Mindfulness meditation activates multiple brain regions that contain a high expression of opioid receptors. However, it is unknown whether mindfulness-meditation-based analgesia is mediated by endogenous opioids. The present double-blind, randomized study examined behavioral pain responses in healthy human volunteers during mindfulness meditation and a nonmanipulation control condition in response to noxious heat and intravenous administration of the opioid antagonist naloxone (0.15 mg/kg bolus + 0.1 mg/kg/h infusion) or saline placebo. Meditation during saline infusion significantly reduced pain intensity and unpleasantness ratings when compared to the control + saline group. However, naloxone infusion failed to reverse meditation-induced analgesia. There were no significant differences in pain intensity or pain unpleasantness reductions between the meditation + naloxone and the meditation + saline groups. Furthermore, mindfulness meditation during naloxone produced significantly greater reductions in pain intensity and unpleasantness than the control groups. These findings demonstrate that mindfulness meditation does not rely on endogenous opioidergic mechanisms to reduce pain.

The secrets to a long and happy life.

Going through my queue of references that might become mindblog posts I come across this piece by O'Connor, describing findings from the Harvard Study of Adult Development, a research project that since 1938 has closely tracked and examined the lives of more than 700 men and in some cases their spouses.

...one of the most important predictors of whether you age well and live a long and happy life is not the amount of money you amass or notoriety you receive. A much more important barometer of long term health and well-being is the strength of your relationships with family, friends and spouses.

...the study has produced many notable findings. It showed, for example, that to age well physically, the single most important thing you could do was to avoid smoking. It discovered that aging liberals had longer and more active sex lives than conservatives. It found that alcohol was the primary cause of divorce among men in the study, and that alcohol abuse often preceded depression (rather than the other way around).

The people in the strongest relationships were protected against chronic disease, mental illness and memory decline – even if those relationships had many ups and downs...people who sought to replace old colleagues with new friends after retiring were happier and healthier than those who left work and placed less emphasis on maintaining strong social networks...Over and over in these 75 years...the study has shown that the people who fared the best were the people who leaned into relationships with family, with friends and with community.

Why we become more cautious with age.

Rutledge et al. find that the decrease in risk-taking that occurs on aging may be related to dopamine-modulated changes in Pavlovian approach behavior, and not a reduction in the subjective value of incremental rewards as traditional models from economics and psychology would have claimed.

Highlights

•Aging reduced risk taking for potential gains but not potential losses
•Computational models revealed that a Pavlovian influence of reward decreased with age
•Age-related dopamine decline can explain the decrease in Pavlovian biaseswhy we

Summary

The extent to which aging affects decision-making is controversial. Given the critical financial decisions that older adults face (e.g., managing retirement funds), changes in risk preferences are of particular importance. Although some studies have found that older individuals are more risk averse than younger ones, there are also conflicting results, and a recent meta-analysis found no evidence for a consistent change in risk taking across the lifespan. There has as yet been little examination of one potential substrate for age-related changes in decision-making, namely age-related decline in dopamine, a neuromodulator associated with risk-taking behavior. Here, we characterized choice preferences in a smartphone-based experiment (n = 25,189) in which participants chose between safe and risky options. The number of risky options chosen in trials with potential gains but not potential losses decreased gradually over the lifespan, a finding with potentially important economic consequences for an aging population. Using a novel approach-avoidance computational model, we found that a Pavlovian attraction to potential reward declined with age. This Pavlovian bias has been linked to dopamine, suggesting that age-related decline in this neuromodulator could lead to the observed decrease in risk taking.

(You might also check out this article on how monkeys, like humans, become less sociable with age.)

A simple model for why moderate beliefs rarely prevail.

I attend the weekly chaos and complexity seminar at the University of Wisconsin when I am in Madison WI during the summer. I want to pass on the paper by Marvel et al. in Physical Review Letters that was discussed this past week, as well a few clips from a review by Zyga discussing its purely mathematical "model of ideological revolution.":

We live in a world of extremes, where being fervently for or against an issue often becomes the dominant social ideology – until an opposing belief that is equally extreme emerges to challenge the first one, eventually becoming the new social paradigm. And so the cycle repeats, with one ideological extreme replacing another, and neither delivering a sustainable solution. Political revolutions, economic bubbles, booms and busts in consumer confidence, and short-lived reforms such as Prohibition in the US all follow this kind of cycle. Why, researchers want to know, does a majority of the population not settle on an intermediate position that blends the best of the old and new?

The model of ideological revolution begins with a community consisting of four types of individuals: those that currently hold an extreme opinion A, those that hold the opposing extreme opinion B, those that hold neither A nor B (the moderates), and those that hold A indefinitely and never change their minds (the A zealots).

To run the model, two individuals are randomly selected to interact with each other, with one randomly chosen to be the speaker and the other the listener. If the speaker is an A or B and the listener is a B or A, respectively, the speaker changes the listener's beliefs to AB. If the listener is an AB, then the listener becomes an A if the speaker is an A, and becomes a B if the speaker is a B. Moderate speakers cannot change a listener's beliefs; only extremists rally others toward their cause.

Running this basic model, the researchers found that the proportion of zealots strongly affects the outcome. When zealots are below a critical value, the system remains similar to how it started. But above a critical value, the zealots quickly convert the entire population to A...Marvel noted that "a raft of alternatives to our basic model (built from different assumed interactions) all show the same threshold behavior: when the committed believers reach a certain fraction of the community, they are capable of converting everyone to their perspective," Marvel said. "This suggests that a similar threshold may appear in real systems even when those real systems have dynamics somewhat different from our basic model. As the American anthropologist Margaret Mead is claimed to have said, 'Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has.'"

The researchers tested seven different strategies for increasing the moderate subpopulation in the model...only one could effectively expand the moderate subpopulation – and the strategy was based not on social interaction but on other environmental stimuli, which might take the form of a media campaign in real life. By integrating this new parameter into the model, the number of moderates increased without threat of extinction.

"The one successful strategy, nonsocial deradicalization, involves a particularly strong sort of encouragement of moderation; for example, its terms with the new parameter are independent of the size of the moderate population," Marvel said. "Hence, our findings suggest that this strong form of encouragement may be necessary for spreading a balanced perspective in a sustainable way."

The researchers note that this strategy should be regarded with caution, given that they have not attempted to show that the model's dynamics accurately represent the real world, with its multiple small-scale ideologies, fragmentation of opinions, and other intricacies. Nevertheless, they hope that this general framework for testing possible strategies that encourage moderation may lead to the discovery of more sophisticated methods.

The Myth of Cosmopolitanism

I pass on the initial paragraphs of Douthat's excellent Op-Ed piece in Sunday's NYTimes. It it well worth a read:

NOW that populist rebellions are taking Britain out of the European Union and the Republican Party out of contention for the presidency, perhaps we should speak no more of left and right, liberals and conservatives. From now on the great political battles will be fought between nationalists and internationalists, nativists and globalists. From now on the loyalties that matter will be narrowly tribal — Make America Great Again, this blessed plot, this earth, this realm, this England — or multicultural and cosmopolitan.

Well, maybe. But describing the division this way has one great flaw. It gives the elite side of the debate (the side that does most of the describing) too much credit for being truly cosmopolitan.

Genuine cosmopolitanism is a rare thing. It requires comfort with real difference, with forms of life that are truly exotic relative to one’s own. It takes its cue from a Roman playwright’s line that “nothing human is alien to me,” and goes outward ready to be transformed by what it finds.

The people who consider themselves “cosmopolitan” in today’s West, by contrast, are part of a meritocratic order that transforms difference into similarity, by plucking the best and brightest from everywhere and homogenizing them into the peculiar species that we call “global citizens.”

This species is racially diverse (within limits) and eager to assimilate the fun-seeming bits of foreign cultures — food, a touch of exotic spirituality. But no less than Brexit-voting Cornish villagers, our global citizens think and act as members of a tribe.

They have their own distinctive worldview (basically liberal Christianity without Christ), their own common educational experience, their own shared values and assumptions (social psychologists call these WEIRD — for Western, Educated, Industrialized, Rich and Democratic), and of course their own outgroups (evangelicals, Little Englanders) to fear, pity and despise. And like any tribal cohort they seek comfort and familiarity: From London to Paris to New York, each Western “global city” (like each “global university”) is increasingly interchangeable, so that wherever the citizen of the world travels he already feels at home.

The ending lines:

They can’t see that paeans to multicultural openness can sound like self-serving cant coming from open-borders Londoners who love Afghan restaurants but would never live near an immigrant housing project, or American liberals who hail the end of whiteness while doing everything possible to keep their kids out of majority-minority schools.

They can’t see that their vision of history’s arc bending inexorably away from tribe and creed and nation-state looks to outsiders like something familiar from eras past: A powerful caste’s self-serving explanation for why it alone deserves to rule the world.

How exercise enhances brain renewal and growth.

Several studies by now have shown that exercises enhances the production of BDNF (Brain Derived Trophic Factor), which leads to the creation of new nerve cells in the hippocampus (essential for learning and memory - for more on the link of exercise to better mental capacity in older people, see Reynolds.). Sleiman et al. now show that in mice the metabolite β-hydroxybutyrate which increases during heavy exercise induces the activity of BNDF gene promoters. Their detailed abstract:

Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety. However, the exact mechanisms whereby physical exercise produces an induction in brain Bdnf gene expression are not well understood. While pharmacological doses of HDAC inhibitors exert positive effects on Bdnf gene transcription, the inhibitors represent small molecules that do not occur in vivo. Here, we report that an endogenous molecule released after exercise is capable of inducing key promoters of the Mus musculus Bdnf gene. The metabolite β-hydroxybutyrate, which increases after prolonged exercise, induces the activities of Bdnf promoters, particularly promoter I, which is activity-dependent. We have discovered that the action of β-hydroxybutyrate is specifically upon HDAC2 and HDAC3, which act upon selective Bdnf promoters. Moreover, the effects upon hippocampal Bdnf expression were observed after direct ventricular application of β-hydroxybutyrate. Electrophysiological measurements indicate that β-hydroxybutyrate causes an increase in neurotransmitter release, which is dependent upon the TrkB receptor. These results reveal an endogenous mechanism to explain how physical exercise leads to the induction of BDNF.

Cognitive fatigue increases impulsivity.

Sort of makes sense..Blain et al. show that if you use your lateral prefrontal cortex (LPFC) for control process required for an extended intense workday, its function in resisting the temptation of immediate rewards is diminished, you're more likely to eat that late afternoon sugar roll. Their abstract:

The ability to exert self-control is key to social insertion and professional success. An influential literature in psychology has developed the theory that self-control relies on a limited common resource, so that fatigue effects might carry over from one task to the next. However, the biological nature of the putative limited resource and the existence of carry-over effects have been matters of considerable controversy. Here, we targeted the activity of the lateral prefrontal cortex (LPFC) as a common substrate for cognitive control, and we prolonged the time scale of fatigue induction by an order of magnitude. Participants performed executive control tasks known to recruit the LPFC (working memory and task-switching) over more than 6 h (an approximate workday). Fatigue effects were probed regularly by measuring impulsivity in intertemporal choices, i.e., the propensity to favor immediate rewards, which has been found to increase under LPFC inhibition. Behavioral data showed that choice impulsivity increased in a group of participants who performed hard versions of executive tasks but not in control groups who performed easy versions or enjoyed some leisure time. Functional MRI data acquired at the start, middle, and end of the day confirmed that enhancement of choice impulsivity was related to a specific decrease in the activity of an LPFC region (in the left middle frontal gyrus) that was recruited by both executive and choice tasks. Our findings demonstrate a concept of focused neural fatigue that might be naturally induced in real-life situations and have important repercussions on economic decisions.

The brain makes maps of abstract realms.

Underwood summarizes the importance of recent work by Constantinescu et al.

The brain is a mapmaker. As you navigate a landscape, neurons in a region called the entorhinal cortex fire at multiple locations, marking out a hexagonal grid on a mental map. The discovery of these so-called grid cells, and their role as a neuronal GPS for spatial navigation, won the 2014 Nobel Prize in Physiology or Medicine for Norwegian scientists Edvard Moser and May-Britt Moser. Now, it seems that the brain may make maps of abstract realms, too. A team at the University of Oxford in the United Kingdom provides evidence that gridlike neuronal activity throughout the brain helps people organize nonnavigation knowledge—for the purposes of the new study, differences in body shape between various types of birds. Several brain regions, including the entorhinal cortex and the ventromedial prefrontal cortex, showed gridlike neural representation of conceptual space.

The abstract of the article:

It has been hypothesized that the brain organizes concepts into a mental map, allowing conceptual relationships to be navigated in a manner similar to that of space. Grid cells use a hexagonally symmetric code to organize spatial representations and are the likely source of a precise hexagonal symmetry in the functional magnetic resonance imaging signal. Humans navigating conceptual two-dimensional knowledge showed the same hexagonal signal in a set of brain regions markedly similar to those activated during spatial navigation. This gridlike signal is consistent across sessions acquired within an hour and more than a week apart. Our findings suggest that global relational codes may be used to organize nonspatial conceptual representations and that these codes may have a hexagonal gridlike pattern when conceptual knowledge is laid out in two continuous dimensions.

Training our brains without our awareness.

There is growing interest in the use of neurofeedback (NF) as a tool to study and treat various clinical conditions. The uses of NF are diverse, ranging across a variety of motor and sensory tasks, investigation of cortical plasticity and attention, to treatment of chronic pain, depression, and mood control. In NF studies participants are typically aware that they are being trained, and received specific goals for this training. Ramos et al. take the important step of showing that targeted brain networks can be modulated even in the complete absence of participants' awareness that a training process is taking place. From their introduction:

...participants were informed that they were engaged in a task aimed at mapping reward networks. Unbeknownst to them, these rewards were coupled with fMRI activations in specific cortical networks. Participants received auditory feedback associated with positive and negative rewards, based on blood oxygen level-dependent (BOLD)–fMRI activity from two well-researched visual regions of interest (ROIs), the fusiform face area (FFA) and the parahippocampal place area (PPA). However, participants were not informed of this procedure and believed, as revealed also by postscan interviews and questionnaires, that the reward was given at random.

They found that 10 of 16 participants were indeed able to modulate their brain activity to enhance the positive rewards, and were completely unaware that they were doing this. This ability was associated with changes in connectivity that were apparent in post-training rest sessions, indicating that the network changes resulting from the training carried over beyond the training period itself. The authors point out:

...that brain networks can be modified even in the complete absence of intention and awareness of the learning situation, raising intriguing possibilities for clinical interventions.

Much ado about grit.

Grit seems to have replaced resilience as the psychological virtue du jour, and like resilience (see Sehgal's piece " on "The profound emptiness of resilience") is getting some kick-back, as in this meta-analysis by Credé et al. of the 'grit literature' suggesting that "interventions designed to enhance grit may only have weak effects on performance and success, the construct validity of grit is in question, and the primary utility of the grit construct may lie in the perseverance facet." (Also, you might check out this article by Selingo asking whether 'grit' is overrated in explaining student success.)

Grit has been presented as a higher order personality trait that is highly predictive of both success and performance and distinct from other traits such as conscientiousness. This paper provides a meta-analytic review of the grit literature with a particular focus on the structure of grit and the relation between grit and performance, retention, conscientiousness, cognitive ability, and demographic variables. Our results based on 584 effect sizes from 88 independent samples representing 66,807 individuals indicate that the higher order structure of grit is not confirmed, that grit is only moderately correlated with performance and retention, and that grit is very strongly correlated with conscientiousness. We also find that the perseverance of effort facet has significantly stronger criterion validities than the consistency of interest facet and that perseverance of effort explains variance in academic performance even after controlling for conscientiousness. In aggregate our results suggest that interventions designed to enhance grit may only have weak effects on performance and success, that the construct validity of grit is in question, and that the primary utility of the grit construct may lie in the perseverance facet.

Why do Greek statues have such small penises?

Time for a random wild-card post, passing on Andrew Lear's speculations on Greek statues, as summarized in a piece by Olivia Goldhill. A few clips:

Don’t pretend your eyes don’t hover, at least for a moment, over the delicately sculpted penises on classical nude statues. While it may not sound like the most erudite subject, art historians haven’t completely ignored ancient Greek genitalia either...it turns out there’s a well-developed ideology behind those rather small penises...In ancient Greece, it seems, a small penis was the sought-after look for the alpha male.

“Greeks associated small and non-erect penises with moderation, which was one of the key virtues that formed their view of ideal masculinity,” explains classics professor Andrew Lear, who has taught at Harvard, Columbia and NYU and runs tours focused on gay history. “There is the contrast between the small, non-erect penises of ideal men (heroes, gods, nude athletes etc) and the over-size, erect penises of Satyrs (mythic half-goat-men, who are drunkards and wildly lustful) and various non-ideal men. Decrepit, elderly men, for instance, often have large penises...Similar ideas are reflected in ancient Greek literature, says Lear. For example, in Aristophanes’ Clouds a large penis is listed alongside a “pallid complexion,” a “narrow chest,” and “great lewdness” as one of the characteristics of un-athletic and dishonorable Athenian youths.”

There are several theories as to why the “ideal” penis size developed from small in ancient Greece to large today. Lear suggests that perhaps the rise of porn, or an ideological push to subject men to the same body shaming that women typically face, are behind the modern emphasis on having a large penis...But Lear adds that in both societies, ideas about penis size are completely “unrelated to reality or aesthetics.” Contrary to popular myth, there’s no clear evidence that a large penis correlates with sexual satisfaction. Nor is there proof that a small penis is a sign of moderation and rationality...Society has been transformed in the thousands of years since ancient Greece but, when it comes to penis size, we’ve simply swapped one groundless theory for another.

Think less, think better.

In an NYTimes piece, Moshe Bar translates the psycho-speak (which caused me to completely miss the point of the work) of an article describing research done with with graduate student Shira Baror. Some clips from the NYTimes pieces, then the article abstract:

Shira Baror and I demonstrate that the capacity for original and creative thinking is markedly stymied by stray thoughts, obsessive ruminations and other forms of “mental load.” Many psychologists assume that the mind, left to its own devices, is inclined to follow a well-worn path of familiar associations. But our findings suggest that innovative thinking, not routine ideation, is our default cognitive mode when our minds are clear.

...we gave participants a free-association task while simultaneously taxing their mental capacity to different degrees...they were given a word (e.g., shoe) and asked to respond as quickly as possible with the first word that came to mind (e.g., sock)...We found that a high mental load consistently diminished the originality and creativity of the response: Participants with seven digits to recall resorted to the most statistically common responses (e.g., white/black), whereas participants with two digits gave less typical, more varied pairings (e.g., white/cloud).

In another experiment, we found that longer response times were correlated with less diverse responses, ruling out the possibility that participants with low mental loads simply took more time to generate an interesting response. Rather, it seems that with a high mental load, you need more time to generate even a conventional thought. These experiments suggest that the mind’s natural tendency is to explore and to favor novelty, but when occupied it looks for the most familiar and inevitably least interesting solution...Our study suggests that your internal exploration is too often diminished by an overly occupied mind, much as is the case with your experience of your external environment.

After practicing vipassana meditation:

My thoughts — when I returned to the act of thinking about something rather than nothing — were fresher and more surprising...It is clear to me that this ancient meditative practice helps free the mind to have richer experiences of the present. Except when you are flying an F-16 aircraft or experiencing extreme fear or having an orgasm, your life leaves too much room for your mind to wander. As a result, only a small fraction of your mental capacity remains engaged in what is before it, and mind-wandering and ruminations become a tax on the quality of your life. Honing an ability to unburden the load on your mind, be it through meditation or some other practice, can bring with it a wonderfully magnified experience of the world — and, as our study suggests, of your own mind.

Now, here is the abstract of their article titled "Associative Activation and Its Relation to Exploration and Exploitation in the Brain," which, when I first scanned it, gave me no clue of the exegesis above!

Associative activation is commonly assumed to rely on associative strength, such that if A is strongly associated with B, B is activated whenever A is activated. We challenged this assumption by examining whether the activation of associations is state dependent. In three experiments, subjects performed a free-association task while the level of a simultaneous load was manipulated in various ways. In all three experiments subjects in the low-load conditions provided significantly more diverse and original associations compared with subjects in the high-load conditions, who exhibited high consensus. In an additional experiment, we found increased semantic priming of immediate associations under high load and of remote associations under low load. Taken together, these findings imply that activation of associations is an exploratory process by default, but is narrowed to exploiting the more immediate associations under conditions of high load. We propose a potential mechanism for processing associations in exploration and in exploitation modes, and suggest clinical implications.

Smartphone Era Politics

Selections from one of Roger Cohen's many intelligent essays in The New York Times:

The time has come for a painful confession: I have spent my life with words, yet I am illiterate...I do not have the words to be at ease in this world of steep migration from desktop to mobile, of search-engine optimization, of device-agnostic bundles, of cascading metrics and dashboards and buckets, of post-print onboarding and social-media FOMO (fear of missing out).

I was more at home with the yarn du jour. Jour was once an apt first syllable for the word journalism; hour would now be more appropriate...That was in the time of distance. Disconnection equaled immersion. Today, connection equals distraction...

We find ourselves at a pivot point. How we exist in relation to one another is in the midst of radical redefinition, from working to flirting. The smartphone is a Faustian device, at once liberation and enslavement. It frees us to be anywhere and everywhere — and most of all nowhere. It widens horizons. It makes those horizons invisible. Upright homo sapiens, millions of years in the making, has yielded in a decade to the stooped homo sapiens of downward device-dazzled gaze.

Perhaps this is how the calligrapher felt after 1440, when it began to be clear what Gutenberg had wrought. A world is gone. Another, as poor Jeb Bush (!) discovered, is being born — one where words mean everything and the contrary of everything, where sentences have lost their weight, where volume drowns truth.

You have to respect American voters. They are changing the lexicon in their anger with the status quo. They don’t care about consistency. They care about energy. Reasonableness dies. Provocation works. Whether you are for or against something, or both at the same time, is secondary to the rise your position gets. Our times are unpunctuated. Politics, too, has a new language, spoken above all by the Republican front-runner as he repeats that, “There is something going on.”...This appears to be some form of addictive delirium. It is probably dangerous in some still unknowable way.

Technology has upended not only newspapers. It has upended language itself, which is none other than a community’s system of communication. What is a community today? (One thing young people don't do on their smartphones is actually talk to each other.) Can there be community at all with downward gazes? I am not sure. But I am certain that cross-platform content has its beauty and its promise if only I could learn the right words to describe them.

Confronting the prejudiced brain

I want to pass on a clip from an essay published on the greater good science center's website. The article is worth reading in its entirety, and you should consider clicking around the greater good website to check other articles on core themes like compassion, empathy, altruism, gratitude, etc.

Recent studies using sophisticated brain imaging techniques have offered an unprecedented glimpse into the psychology of prejudice, and the results aren’t always pretty. In research by Princeton psychology professor Susan Fiske, for instance, white study participants were shown photographs of white and black faces while a functional magnetic resonance imaging scanner captured their brain activity. When asked a seemingly harmless question about the age of the face shown, participants’ brain activity spiked in a region known as the amygdala, which is involved in the fear response—it lights up when we encounter threats.

Yet when participants were asked to guess the favorite vegetable of each individual pictured, amygdala activity was no more stimulated by black faces than it was by white ones. In other words, when the study participants had to group people into a social category—even if it was by age rather than race—their brains reacted more negatively to black faces than to white faces. But when they were encouraged to see everyone as individuals with their own tastes and feelings—tastes and feelings just like the ones they have themselves—their reactions to black faces and white faces didn’t differ. Their fear dissolved as they no longer saw the black faces as others.

This research shows how it’s possible to shift perceptions of in-groups and out-groups in a lab. But how do we do this in real life? One of social psychology’s most influential theories about incorporating others into the in-group is called the contact hypothesis. Formulated by Harvard social psychologist Gordon Allport in the 1940s, the theory itself is straightforward: Increasing exposure to out-group members will improve attitudes toward that group and decrease prejudice and stereotyping. By no means an idealist, Allport recognized that contact between groups can also devolve into conflict and further reinforce negative attitudes. In fact, he argued that contact would bring positive results only when four specific conditions were in place for the groups involved:

-the support of legitimate authorities; 

-common goals; 

-a sense of interdependency that provides an incentive to cooperate; and 

-a sense of having of equal status.

Predicting whether you are going to vote.

An interesting nugget from Rogers et al., who find that callers to potential voters are more likely to correctly predict whether the person called will vote than the person called is:

People are regularly asked to report on their likelihoods of carrying out consequential future behaviors, including complying with medical advice, completing educational assignments, and voting in upcoming elections. Despite these stated self-predictions being notoriously unreliable, they are used to inform many strategic decisions. We report two studies examining stated self-prediction about whether citizens will vote. We find that most self-predicted voters do not actually vote despite saying they will, and that campaign callers can discern which self-predicted voters will not actually vote. In study 1 (n = 4,463), self-predicted voters rated by callers as “100% likely to vote” were 2 times more likely to actually vote than those rated unlikely to vote. Study 2 (n = 3,064) replicated this finding and further demonstrated that callers’ prediction accuracy was mediated by citizens’ nonverbal signals of uncertainty and deception. Strangers can use nonverbal signals to improve predictions of follow through on self-reported intentions—an insight of potential value for politics, medicine, and education.

Yes, there have been aliens.

This post falls under the "random curious stuff" category in MindBlog's description line. Adam Frank gives an interesting account of work he has published with Woodruff Sullivan arguing that we now have enough information to conclude that alien civilizations have almost certainly existed at some point in cosmic history.

Among scientists, the probability of the existence of an alien society with which we might make contact is discussed in terms of something called the Drake equation.... Drake identified seven factors on which that number would depend, and incorporated them into an equation.

The first factor was the number of stars born each year. The second was the fraction of stars that had planets. After that came the number of planets per star that traveled in orbits in the right locations for life to form (assuming life requires liquid water). The next factor was the fraction of such planets where life actually got started. Then came factors for the fraction of life-bearing planets on which intelligence and advanced civilizations (meaning radio signal-emitting) evolved. The final factor was the average lifetime of a technological civilization.

In 1961, only the first factor — the number of stars born each year — was understood. And that level of ignorance remained until very recently...Three of the seven terms in Drake’s equation are now known. We know the number of stars born each year. We know that the percentage of stars hosting planets is about 100. And we also know that about 20 to 25 percent of those planets are in the right place for life to form. This puts us in a position, for the first time, to say something definitive about extraterrestrial civilizations — if we ask the right question.

In our recent paper, Professor Sullivan and I did this by shifting the focus of Drake’s equation. Instead of asking how many civilizations currently exist, we asked what the probability is that ours is the only technological civilization that has ever appeared. By asking this question, we could bypass the factor about the average lifetime of a civilization. This left us with only three unknown factors, which we combined into one “biotechnical” probability: the likelihood of the creation of life, intelligent life and technological capacity.

You might assume this probability is low, and thus the chances remain small that another technological civilization arose. But what our calculation revealed is that even if this probability is assumed to be extremely low, the odds that we are not the first technological civilization are actually high. Specifically, unless the probability for evolving a civilization on a habitable-zone planet is less than one in 10 billion trillion, then we are not the first.

To give some context for that figure: In previous discussions of the Drake equation, a probability for civilizations to form of one in 10 billion per planet was considered highly pessimistic. According to our finding, even if you grant that level of pessimism, a trillion civilizations still would have appeared over the course of cosmic history.

In other words, given what we now know about the number and orbital positions of the galaxy’s planets, the degree of pessimism required to doubt the existence, at some point in time, of an advanced extraterrestrial civilization borders on the irrational.

The mistrust of science

Atul Gawande offers another fascinating essay, in the form of his commencement speech at the California Institute of Technology on June 10. A few clips:

The scientific orientation has proved immensely powerful. It has allowed us to nearly double our lifespan during the past century, to increase our global abundance, and to deepen our understanding of the nature of the universe. Yet scientific knowledge is not necessarily trusted. Partly, that’s because it is incomplete. But even where the knowledge provided by science is overwhelming, people often resist it—sometimes outright deny it. Many people continue to believe, for instance, despite massive evidence to the contrary, that childhood vaccines cause autism (they do not); that people are safer owning a gun (they are not); that genetically modified crops are harmful (on balance, they have been beneficial); that climate change is not happening (it is).

The sociologist Gordon Gauchat studied U.S. survey data from 1974 to 2010 and found some deeply alarming trends. Despite increasing education levels, the public’s trust in the scientific community has been decreasing. This is particularly true among conservatives, even educated conservatives. In 1974, conservatives with college degrees had the highest level of trust in science and the scientific community. Today, they have the lowest.

Today, we have multiple factions putting themselves forward as what Gauchat describes as their own cultural domains, “generating their own knowledge base that is often in conflict with the cultural authority of the scientific community.” Some are religious groups (challenging evolution, for instance). Some are industry groups (as with climate skepticism). Others tilt more to the left (such as those that reject the medical establishment). As varied as these groups are, they are all alike in one way. They all harbor sacred beliefs that they do not consider open to question.

Science’s defenders have identified five hallmark moves of pseudoscientists. They argue that the scientific consensus emerges from a conspiracy to suppress dissenting views. They produce fake experts, who have views contrary to established knowledge but do not actually have a credible scientific track record. They cherry-pick the data and papers that challenge the dominant view as a means of discrediting an entire field. They deploy false analogies and other logical fallacies. And they set impossible expectations of research: when scientists produce one level of certainty, the pseudoscientists insist they achieve another.

The challenge of what to do about this—how to defend science as a more valid approach to explaining the world—has actually been addressed by science itself. Scientists have done experiments. In 2011, two Australian researchers compiled many of the findings in “The Debunking Handbook.” The results are sobering. The evidence is that rebutting bad science doesn’t work; in fact, it commonly backfires. Describing facts that contradict an unscientific belief actually spreads familiarity with the belief and strengthens the conviction of believers. That’s just the way the brain operates; misinformation sticks, in part because it gets incorporated into a person’s mental model of how the world works. Stripping out the misinformation therefore fails, because it threatens to leave a painful gap in that mental model—or no model at all.

Emerging from the findings was also evidence that suggested how you might build trust in science. Rebutting bad science may not be effective, but asserting the true facts of good science is. And including the narrative that explains them is even better. You don’t focus on what’s wrong with the vaccine myths, for instance. Instead, you point out: giving children vaccines has proved far safer than not. How do we know? Because of a massive body of evidence, including the fact that we’ve tried the alternate experiment before. Between 1989 and 1991, vaccination among poor urban children in the U.S. dropped. And the result was fifty-five thousand cases of measles and a hundred and twenty-three deaths.

Knowledge and the virtues of the scientific orientation live far more in the community than the individual. When we talk of a “scientific community,” we are pointing to something critical: that advanced science is a social enterprise, characterized by an intricate division of cognitive labor. Individual scientists, no less than the quacks, can be famously bull-headed, overly enamored of pet theories, dismissive of new evidence, and heedless of their fallibility. (Hence Max Planck’s observation that science advances one funeral at a time.) But as a community endeavor, it is beautifully self-correcting.

Beautifully organized, however, it is not. Seen up close, the scientific community—with its muddled peer-review process, badly written journal articles, subtly contemptuous letters to the editor, overtly contemptuous subreddit threads, and pompous pronouncements of the academy— looks like a rickety vehicle for getting to truth. Yet the hive mind swarms ever forward. It now advances knowledge in almost every realm of existence—even the humanities, where neuroscience and computerization are shaping understanding of everything from free will to how art and literature have evolved over time.

The mistake...is to believe that the educational credentials you get... give you any special authority on truth. What you have gained is far more important: an understanding of what real truth-seeking looks like. It is the effort not of a single person but of a group of people—the bigger the better—pursuing ideas with curiosity, inquisitiveness, openness, and discipline. As scientists, in other words.

Even more than what you think, how you think matters. The stakes for understanding this could not be higher than they are today, because we are not just battling for what it means to be scientists. We are battling for what it means to be citizens.

Our (Bare) Shelves, Our Selves

As is the case with many people moving through their 70's, I am having to downsize my surroundings. An 1861 stone schoolhouse converted to a residence that has been my Madison WI home for the past 26 years is going on the market next week as my husband and I contract into a smaller condo near the university for the 4-5 summer months we spend away from Fort Lauderdale. Old record, tape, CD, and book collections that have been a part of my extended ego are being discarded or massively downsized. It feels like a series of amputations, even though for years all my reading and music listening have not required any of these objects. Rather, they are being downloaded (Amazon Kindle, iPad) or streamed from the internet (Apple Music,Pandora, Google Play, etc.). My valued music CDs have been transferred to iTunes. The visual richness and emotions evoked by the history of my filled book shelves is hardly matched by the two devices that can now perform their functions, an iPad and a wireless speaker. This feeling of loss is why a recent Op-Ed piece by Teddy Wayne having the title of this post resonated with me. The transition I am describing is occurring in the homes of children growing up with parents who have moved from books and CDs to Kindle and streaming. In such settings there can be fewer random walks through a book, record, or CD collection that find novel material, you're looking more for what you think you want. The final paragraphs of Wayne's essay:

Poking through physical artifacts, as I did with those Beatles records, is archival and curatorial; it forces you to examine each object slowly, perhaps sample it and come across a serendipitous discovery.

Scrolling through file names on a device, on the other hand, is what we do all day long, often mindlessly, in our quest to find whatever it is we’re already looking for as rapidly as possible. To see “The Beatles” in a list of hundreds of artists in an iTunes database is not nearly as arresting as holding the album cover for “Sgt. Pepper’s Lonely Hearts Club Band.”

Consider the difference between listening to music digitally versus on a record player or CD. On the former, you’re more likely to download or stream only the singles you want to hear from an album. The latter requires enough of an investment — of acquiring it, but also of energy in playing it — that you stand a better chance of committing and listening to the entire album.

If I’d merely clicked on the first MP3 track of “Sgt. Pepper’s” rather than removed the record from its sleeve, placed it in the phonograph and carefully set the needle over it, I may have become distracted and clicked elsewhere long before the B-side “Lovely Rita” played.

And what of sentiment? Jeff Bezos himself would have a hard time defending the nostalgic capacity of a Kindle .azw file over that of a tattered paperback. Data files can’t replicate the lived-in feel of a piece of beloved art. To a child, a parent’s dog-eared book is a sign of a mind at work and of the personal significance of that volume.

A crisp JPEG of the cover design on a virtual shelf, however, looks the same whether it’s been reread 10 times or not at all. If, that is, it’s ever even seen.

Vision reconstructs causal history from static shapes.

From Chen and Scholl:

The perception of shape, it has been argued, also often entails the perception of time. A cookie missing a bite, for example, is seen as a whole cookie that was subsequently bitten. It has never been clear, however, whether such observations truly reflect visual processing. To explore this possibility, we tested whether the perception of history in static shapes could actually induce illusory motion perception. Observers watched a square change to a truncated form, with a “piece” of it missing, and they reported whether this change was sudden or gradual. When the contours of the missing piece suggested a type of historical “intrusion” (as when one pokes a finger into a lump of clay), observers actually saw that intrusion occur: The change appeared to be gradual even when it was actually sudden, in a type of transformational apparent motion. This provides striking phenomenological evidence that vision involves reconstructing causal history from static shapes.

A postdictive illusion of choice.

Bear and Bloom report a simple experiment showing how we can feel as if we make a choice before the time at which this choice is actually made.

Do people know when, or whether, they have made a conscious choice? Here, we explore the possibility that choices can seem to occur before they are actually made. In two studies, participants were asked to quickly choose from a set of options before a randomly selected option was made salient. Even when they believed that they had made their decision prior to this event, participants were significantly more likely than chance to report choosing the salient option when this option was made salient soon after the perceived time of choice. Thus, without participants’ awareness, a seemingly later event influenced choices that were experienced as occurring at an earlier time. These findings suggest that, like certain low-level perceptual experiences, the experience of choice is susceptible to “postdictive” influence and that people may systematically overestimate the role that consciousness plays in their chosen behavior.

From their text:

In the first experiment participants viewed five white circles that appeared in random positions on a computer screen and were asked to try to quickly choose one of these circles “in their head” before one of the circles turned red. After a circle turned red, participants indicated whether they had chosen the red circle, had chosen a circle that did not turn red, or had not had enough time to choose a circle before one of them turned red.

Because the red circle is selected randomly on all trials, people performing this task should choose the red circle on approximately 20% of the trials in which they claim to have had time to make a choice if they are, in fact, making their choices before a circle turns red (and they are not biased to report choosing the red circle for some other reason). In contrast, a postdictive model predicts that people could consciously experience having made a choice before a circle turned red even though this choice did, in fact, occur after a circle turned red and was influenced by that event. Specifically, this could happen if a circle turns red soon enough to bias a person’s choice unconsciously (e.g., by subliminally capturing visual attention..), but this person completes the choice before becoming conscious of the circle’s turning red. On the other hand, if there is a relatively long delay until a circle turns red, a person would be more likely to have finished making a choice before even unconsciously processing a circle’s turning red; hence, this event would be less likely to bias the choice.

In a second experiment, we explored whether postdiction could occur in a slightly different paradigm, in which participants chose one of two different-colored circles. We used two, rather than five, choice options in this experiment to control for a worry that the time-dependent bias we observed in Experiment 1 could have been driven by low-confidence responding. If participants were less confident in choices they made more quickly, they might have been prone to choose relatively randomly between the “y” and “n” response options in short-delay trials. Such a random pattern of responding would have biased participants’ reports of choosing the red circle toward .50 (because there were only two response options), and would have resulted in greater-than-chance reports of choosing the red circle for these shorter delays (because chance was .20 in Experiment 1). By making chance .50 in this experiment, we eliminated any concern that random responding could yield the time-dependent pattern of bias that we observed in Experiment 1.

Reducing stress induced inflammatory disease with bacteria.

Interesting work from Reber et al.:

Significance

The hygiene, or “old friends,” hypothesis proposes that lack of exposure to immunoregulatory microorganisms in modern urban societies is resulting in an epidemic of inflammatory disease, as well as psychiatric disorders in which chronic, low-level inflammation is a risk factor. An important determinant of immunoregulation is the microbial community occupying the host organism, collectively referred to as the microbiota. Here we show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Treatment of mice with a heat-killed preparation of an immunoregulatory environmental microorganism, Mycobacterium vaccae, prevents stress-induced pathology. These data support a strategy of “reintroducing” humans to their old friends to promote optimal health and wellness.

Abstract

The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated immunization with a heat-killed preparation of Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor in a murine model of chronic psychosocial stress when tested 1–2 wk following the final immunization. Furthermore, immunization with M. vaccae prevented stress-induced spontaneous colitis and, in stressed mice, induced anxiolytic or fear-reducing effects as measured on the elevated plus-maze, despite stress-induced gut microbiota changes characteristic of gut infection and colitis. Immunization with M. vaccae also prevented stress-induced aggravation of colitis in a model of inflammatory bowel disease. Depletion of regulatory T cells negated protective effects of immunization with M. vaccae on stress-induced colitis and anxiety-like or fear behaviors. These data provide a framework for developing microbiome- and immunoregulation-based strategies for prevention of stress-related pathologies.

Unethical amnesia

From Kouchaki and Gino:

Despite our optimistic belief that we would behave honestly when facing the temptation to act unethically, we often cross ethical boundaries. This paper explores one possibility of why people engage in unethical behavior over time by suggesting that their memory for their past unethical actions is impaired. We propose that, after engaging in unethical behavior, individuals’ memories of their actions become more obfuscated over time because of the psychological distress and discomfort such misdeeds cause. In nine studies (n = 2,109), we show that engaging in unethical behavior produces changes in memory so that memories of unethical actions gradually become less clear and vivid than memories of ethical actions or other types of actions that are either positive or negative in valence. We term this memory obfuscation of one’s unethical acts over time “unethical amnesia.” Because of unethical amnesia, people are more likely to act dishonestly repeatedly over time.

The attention economy

I pass on some clips from an essay by Tom Chatfield:

How many other things are you doing right now while you’re reading this piece? Are you also checking your email, glancing at your Twitter feed, and updating your Facebook page? What five years ago David Foster Wallace labelled ‘Total Noise’ — ‘the seething static of every particular thing and experience, and one’s total freedom of infinite choice about what to choose to attend to’ — is today just part of the texture of living on a planet that will, by next year, boast one mobile phone for each of its seven billion inhabitants. We are all amateur attention economists, hoarding and bartering our moments…

Much as corporations incrementally improve the taste, texture and sheer enticement of food and drink by measuring how hard it is to stop eating and drinking them, the actions of every individual online are fed back into measures where moreinexorably means better: more readers, more viewers, more exposure, more influence, more ads, more opportunities to unfurl the integrated apparatus of gathering and selling data. Attention, thus conceived, is an inert and finite resource, like oil or gold: a tradable asset that the wise manipulator auctions off to the highest bidder, or speculates upon to lucrative effect. There has even been talk of the world reaching ‘peak attention’, by analogy to peak oil production, meaning the moment at which there is no more spare attention left to spend.

There’s a reductive exaltation in defining attention as the contents of a global reservoir, slopping interchangeably between the brains of every human being alive. Where is the space, here, for the idea of attention as a mutual construction more akin to empathy than budgetary expenditure — or for those unregistered moments in which we attend to ourselves, to the space around us, or to nothing at all?

From the loftiest perspective of all, information itself is pulling the strings: free-ranging memes whose ‘purposes’ are pure self-propagation, and whose frantic evolution outstrips all retrospective accounts…consider yourself as interchangeable as the button you’re clicking, as automated as the systems in which you’re implicated. Seen from such a height, you signify nothing beyond your recorded actions…in making our attentiveness a fungible asset, we’re not so much conjuring currency out of thin air as chronically undervaluing our time.

We watch a 30-second ad in exchange for a video; we solicit a friend’s endorsement; we freely pour sentence after sentence, hour after hour, into status updates and stock responses. None of this depletes our bank balances. Yet its cumulative cost, while hard to quantify, affects many of those things we hope to put at the heart of a happy life: rich relationships, rewarding leisure, meaningful work, peace of mind.

What kind of attention do we deserve from those around us, or owe to them in return? What kind of attention do we ourselves deserve, or need, if we are to be ‘us’ in the fullest possible sense? These aren’t questions that even the most finely tuned popularity contest can resolve. Yet, if contentment and a sense of control are partial measures of success, many of us are selling ourselves far too cheap.

A redefinition of health and well-being for older adults

McClintock et al. take a more comprehensive approach to defining health and find some interesting new categories. The healthiest people are obese and robust!

Significance

Health has long been conceived as not just the absence of disease but also the presence of physical, psychological, and social well-being. Nonetheless, the traditional medical model focuses on specific organ system diseases. This representative study of US older adults living in their homes amassed not only comprehensive medical information but also psychological and social data and measured sensory function and mobility, all key factors for independent living and a gratifying life. This comprehensive model revealed six unique health classes, predicting mortality/incapacity. The healthiest people were obese and robust; two new classes, with twice the mortality/incapacity, were people with healed broken bones or poor mental health. This approach provides an empirical method for broadly reconceptualizing health, which may inform health policy.

Abstract

The World Health Organization (WHO) defines health as a “state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.” Despite general acceptance of this comprehensive definition, there has been little rigorous scientific attempt to use it to measure and assess population health. Instead, the dominant model of health is a disease-centered Medical Model (MM), which actively ignores many relevant domains. In contrast to the MM, we approach this issue through a Comprehensive Model (CM) of health consistent with the WHO definition, giving statistically equal consideration to multiple health domains, including medical, physical, psychological, functional, and sensory measures. We apply a data-driven latent class analysis (LCA) to model 54 specific health variables from the National Social Life, Health, and Aging Project (NSHAP), a nationally representative sample of US community-dwelling older adults. We first apply the LCA to the MM, identifying five health classes differentiated primarily by having diabetes and hypertension. The CM identifies a broader range of six health classes, including two “emergent” classes completely obscured by the MM. We find that specific medical diagnoses (cancer and hypertension) and health behaviors (smoking) are far less important than mental health (loneliness), sensory function (hearing), mobility, and bone fractures in defining vulnerable health classes. Although the MM places two-thirds of the US population into “robust health” classes, the CM reveals that one-half belong to less healthy classes, independently associated with higher mortality. This reconceptualization has important implications for medical care delivery, preventive health practices, and resource allocation.

Why do we feel awe?

I want to point to an article by Dacher Keltner on the functions of awe that appeared on the Slate website, along with others sponsored by the John Templeton Foundation. Here are clips describing a few of the experiments he mentions.

A new science is now asking “Why awe?” This is a question we can approach in two ways. First we can consider the long, evolutionary view: Why did awe became part of our species’ emotional repertoire during seven million years of hominid evolution? A preliminary answer is that awe binds us to social collectives and enables us to act in more collaborative ways that enable strong groups, thus improving our odds for survival.

For example, in one study from our Berkeley lab, my colleague Michelle Shiota had participants fill in the blank of the following phrase: “ I AM ____.” They did so 20 times, either while standing before an awe-inspiring replica of a T. rex skeleton in UC Berkeley’s Museum of Paleontology or in the exact same place but oriented to look down a hallway, away from the T. rex. Those looking at the dinosaur were more likely to define their individual selves in collectivist terms—as a member of a culture, a species, a university, a moral cause. Awe embeds the individual self in a social identity.

Near Berkeley’s Museum of Paleontology stands a grove of eucalyptus trees, the tallest in North America. When you gaze up at these trees, with their peeling bark and surrounding nimbus of grayish green light, goosebumps may ripple down your neck, a sure sign of awe...my colleague Paul Piff staged a minor accident near that grove to see if awe would prompt greater kindness...Participants first either looked up into the tall trees for one minute—long enough for them to report being filled with awe—or oriented 90 degrees away to look up at the facade of a large science building. They then encountered a person who stumbled, dropping a handful of pens into the dirt. Sure enough, the participants who had been gazing up at the awe-inspiring trees picked up more pens. Experiencing awe seemed to make them more inclined to help someone in need. They also reported feeling less entitled and self-important than the other study participants did.

Is humanity getting better?

I want to pass on a few clips from a stimulating essay by Leif Wenar, who suggests "The real trick to understanding our world is to see it with both eyes at once. The world now is a thoroughly awful place — compared with what it should be. But not compared with what it was. Keeping both eyes open gives depth to our perception of our own time in history, and makes us better able to see where paths to more progress may be open.":

The 20th century marked an inflection point — the beginning of humanity’s transition from its ancient crises of ignorance to its modern crises of invention. Our science is now so penetrating, our systems are so robust, that we are mostly endangered by our own creations...Our transportation networks are now so fast and far-flung that they transmit diseases worldwide before cures can catch up. The next epidemics will play on our strengths, not our weaknesses — fighting them will mean canceling flights, not killing fleas. This Horseman of the Apocalypse has dismounted and now travels coach.

Indeed, our machines have multiplied so much that a new crisis looms because of the smoke coming off them as they combust. Future food crises, if they come, will be driven by anthropogenic climate change. Famine will descend not from the wrath of God but from the growth of gross domestic product. We ourselves are outfitting the Horsemen of the future, or perhaps it’s better to say that we are creating them...Whether humans can overcome their coming crises of invention will turn on the philosopher’s old question of whether individuals are essentially good or evil, which is a hard question — but recent news will tempt many thumbs to turn downward.

A more positive answer emerges if we switch to a systems perspective, evaluating humanity as a whole as we would an ecosystem or a complex machine. What happens when humanity “adds” energy to itself ... as it’s done massively in the transition from wood and muscle power to fossil fuels and alternatives?..Something is happening to our species, and especially over the last 70 years. The years since 1945 have seen many horrors...Yet this has also been the most prosperous time in human history by far. And by a long way the time with the greatest increase in democracy around the world. It has also been the most peaceful era in recorded human history. As Joshua Goldstein puts it in “Winning the War on War,” “We have avoided nuclear wars, left behind world war, nearly extinguished interstate war, and reduced civil wars to fewer countries with fewer casualties.” Goldstein continues:

In the first half of the twentieth century, world wars killed tens of millions and left whole continents in ruins. In the second half of that century, during the Cold War, proxy wars killed millions, and the world feared a nuclear war that could have wiped out our species. Now, in the early twenty-first century, the worst wars, such as Iraq, kill hundreds of thousands. We fear terrorist attacks that could destroy a city, but not life on the planet. The fatalities still represent a large number and the impacts of wars are still catastrophic for those caught in them, but overall, war has diminished dramatically.

...the big picture of postwar history shows significant improvements in nearly all indicators of lived human experience. The average life span of humans is today longer than it has ever been. A smaller proportion of women die in childbirth than ever before. Child malnutrition is at its lowest level ever, while literacy rates worldwide have never been higher. Most impressive has been the recent reduction in severe poverty — the reduction in the percentage of humans living each day on what a tall Starbucks coffee costs in America. During a recent 20-year stretch the mainstream estimate is that the percentage of the developing world living in such extreme poverty shrank by more than half, from 43 to 21 percent.

Humanity does learn, painfully and often only after thousands or even millions have died ...humanity learns as identities alter to become less aggressive and more open, so that networks can connect individual capacities more effectively and join our resources together.

What we take for granted frames the size of our concerns. We’ve come to expect that mayors and police chiefs will not endorse, much less order, the lynching of minorities. Within that frame, racial profiling and deaths in police custody are top priorities. After decades, we’ve come to expect enduring peace among the great powers. Within that frame any military action by a major power, or a civil war in a resource-rich state, rightly becomes top news.

We can’t relax; the upward trends in time’s graphs may crest at any point. Yet batting away the positive facts is lazy, and requires only a lower form of intelligence.

Telephone metadata does reveal personal details.

Susan Landau reviews work of Mayer et al. that shows President Obama's statement:

When it comes to telephone calls, nobody is listening to your telephone calls. That’s not what this program is about. As was indicated, what the intelligence community is doing is looking at phone numbers and durations of calls. They are not looking at people’s names, and they’re not looking at content.

...is misleading. Mayer et al. convincingly show that call detail records (CDRs) are personally revelatory...

...it can be determined that someone is suffering from a multiple sclerosis relapse, having cardiac arrhythmia problems, seeking to buy an automatic rifle, intending to start a marijuana-growing venture, or having an abortion.

Needless to say, such insight puts communications surveillance law even more in flux. Here is the abstract from Mayer et al:

Since 2013, a stream of disclosures has prompted reconsideration of surveillance law and policy. One of the most controversial principles, both in the United States and abroad, is that communications metadata receives substantially less protection than communications content. Several nations currently collect telephone metadata in bulk, including on their own citizens. In this paper, we attempt to shed light on the privacy properties of telephone metadata. Using a crowdsourcing methodology, we demonstrate that telephone metadata is densely interconnected, can trivially be reidentified, and can be used to draw sensitive inferences.

A science of consciousness carnival in Tucson.

I started teaching my Biology of Mind course at the University of Wisconsin in the early 1990's, and was inspired and stimulated by attending the first of the "Towards a Science of Consciousness" meetings in Tucson, Az. There I met Daniel Dennett, who was very encouraging about my starting my book "The Biology of Mind" which was published in 1999. I attended the following two meetings but then dropped out as pseudoscience, wild speculation about quantum mechanics and consciousness, and New Age gibble-gabble continued make up a substantial fraction of the program. Fewer serious scientists were attending. George Johnson's review of the most recent meeting (now called "The Science of Consciousness," with the original organizer Stuart Hameroff presiding) makes me secure in my decision to have stayed away recently. Some clips from his review:

...wild speculations and carnivalesque pseudoscience were juxtaposed with sober sessions like “Agency and Mental Causation” and data-filled talks about probing conscious brain states with PET scans and EEGs...

...I found myself sitting, late one afternoon, in “Vibrations, Scale, and Topology,” where a musician from Tulsa, Okla., who called himself Timbre Wolf...played a recording of an eerie composition called “Brain Dance,” derived from vibrations generated by tiny molecular structures called microtubules, which are part of the scaffolding of brain cells. The music, to his ear, was reminiscent of Philip Glass, Steve Reich, Cuban rumba, Gustav Holst’s “The Planets,” and the visual rhythms of strange mathematical objects called Penrose tiles...All of this, he suspected, had something to do with quantum mechanics and consciousness, an idea that Dr. Hameroff has long been pursuing.

More disconcerting was the starring role given to the New Age entrepreneur Deepak Chopra. Dr. Chopra believes that human consciousness (through epigenetic feedback) directs the unfolding of human evolution.

No one seemed to object as Dr. Chopra, whose Chopra Foundation was one of the sponsors, shared the stage with prominent professors who engaged with his ideas as if he were another esteemed colleague....Also included in the lineup were presentations hypothesizing that dark energy could explain consciousness and that homeopathic medicine might work through nanoparticles and quantum entanglement — as if homeopathy worked at all.

Sentiments on cynicism and hope.

I want to pass on these clips from a commencement talk given by Maria Popova:

…in every environment densely populated by peers — self-comparison becomes inevitable.….here’s the thing about self-comparison: In addition to making you vacate your own experience, your own soul, your own life, in its extreme it breeds resignation. If we constantly feel that there is something more to be had — something that’s available to those with a certain advantage in life, but which remains out of reach for us — we come to feel helpless. And the most toxic byproduct of this helpless resignation is cynicism — that terrible habit of mind and orientation of spirit in which, out of hopelessness for our own situation, we grow embittered about how things are and about what’s possible in the world. Cynicism is a poverty of curiosity and imagination and ambition.

Today, the soul is in dire need of stewardship and protection from cynicism. The best defense against it is vigorous, intelligent, sincere hope — not blind optimism, because that too is a form of resignation, to believe that everything will work out just fine and we need not apply ourselves. I mean hope bolstered by critical thinking that is clear-headed in identifying what is lacking, in ourselves or the world, but then envisions ways to create it and endeavors to do that.

In its passivity and resignation, cynicism is a hardening, a calcification of the soul. Hope is a stretching of its ligaments, a limber reach for something greater.

Exercise and intermittent fasting improve brain plasticity and health

I have had numerous requests for a PDF of the article referenced in a Dec. 29, 2014 post - on how exercise and fasting stimulate brain plasticity and resilience - with the same title as this post.  It turns out that the reference pointed to by the link is open source. Readers should be able to download the article for themselves. Here is the text of the original post:

I thought it might be useful to point to this brief review by Praag et al. that references several recent pieces of work presented at a recent Soc. for Neuroscience Meeting symposium. The experiments indicate that exercise and intermittent energy restriction/fasting may optimize brain function and forestall metabolic and neurodegenerative diseases by enhancing neurogenesis, synaptic plasticity and neuronal stress robustness.  (Motivated readers can obtain the article from me.) Here is their central summary figure:

Exercise and IER/fasting exert complex integrated adaptive responses in the brain and peripheral tissues involved in energy metabolism. As described in the text, both exercise and IER enhance neuroplasticity and resistance of the brain to injury and disease. Some of the effects of exercise and IER on peripheral organs are mediated by the brain, including increased parasympathetic regulation of heart rate and increased insulin sensitivity of liver and muscle cells. In turn, peripheral tissues may respond to exercise and IER by producing factors that bolster neuronal bioenergetics and brain function. Examples include the following: mobilization of fatty acids in adipose cells and production of ketone bodies in the liver; production of muscle-derived neuroactive factors, such as irisin; and production of as yet unidentified neuroprotective “preconditioning factors.” Suppression of local inflammation in tissues throughout the body and the nervous system likely contributes to prevention and reversal of many different chronic disease processes.

Are electric vehicles really better for the planet?

Some time ago I read a careful analysis of the energy required to manufacture a Toyota Prius, which reported that more energy was expended over the life cycle of the typical vehicle (manufacturing the batteries being very energy intensive) than by a high efficiency gasoline-burning cars. I then lost the reference, and so was pleased to come upon the report below in Science Magazine by Wigginton. Work like this makes me feel a bit less guilty about staying with my cheap Honda Civic, and more able to resist the subtle aura of superiority that I imagine is being emitted by friends smugly driving about in their Toyota Priuses:

Shifting to electric passenger vehicles ideally will reduce the carbon footprint of the transportation sector. Two recent studies, however, show that the greenhouse gas emissions produced over the life cycle of electric vehicles, from production through use, may not always be less than those of gasoline-burning vehicles. Ellingsen et al. reveal that vehicle and battery size prohibit some larger electric vehicles from ever overcoming the high greenhouse gas emissions generated during production. Yuksel et al. show that regional factors in the United States such as electrical grid mix, temperature, and driving conditions strongly limit the potential of plug-in electric vehicles to out-perform high-efficiency gas vehicles. Blanket policies directed at the adoption of electric vehicles therefore could potentially fail to reduce the transportation sector's large carbon footprint.

Culture shapes the evolution of cognition.

From Thompson et al.:

A central debate in cognitive science concerns the nativist hypothesis, the proposal that universal features of behavior reflect a biologically determined cognitive substrate: For example, linguistic nativism proposes a domain-specific faculty of language that strongly constrains which languages can be learned. An evolutionary stance appears to provide support for linguistic nativism, because coordinated constraints on variation may facilitate communication and therefore be adaptive. However, language, like many other human behaviors, is underpinned by social learning and cultural transmission alongside biological evolution. We set out two models of these interactions, which show how culture can facilitate rapid biological adaptation yet rule out strong nativization. The amplifying effects of culture can allow weak cognitive biases to have significant population-level consequences, radically increasing the evolvability of weak, defeasible inductive biases; however, the emergence of a strong cultural universal does not imply, nor lead to, nor require, strong innate constraints. From this we must conclude, on evolutionary grounds, that the strong nativist hypothesis for language is false. More generally, because such reciprocal interactions between cultural and biological evolution are not limited to language, nativist explanations for many behaviors should be reconsidered: Evolutionary reasoning shows how we can have cognitively driven behavioral universals and yet extreme plasticity at the level of the individual—if, and only if, we account for the human capacity to transmit knowledge culturally. Wherever culture is involved, weak cognitive biases rather than strong innate constraints should be the default assumption.