Live younger longer

New Yorker Magazine writer and polymath Adam Gopnik does an excellent article describing studies on our increased longevity that aim to enhance its quality, not its duration. He also describes anti-aging research directed at increasing longevity.  I suggest you read the article. Here are a few clips, mainly from the first part of the article describing the experience of aging:

Over the past century, we’ve created the greatest gift in the history of humanity—thirty extra years of life—and we don’t know what to do with it! Now that we’re living longer, how do we plan for what we’re going to do?

To get a sense of what it would be like to have the slow process of aging become a fast process, you can go to the AgeLab, at the Massachusetts Institute of Technology, in Cambridge, and put on agnes (for Age Gain Now Empathy System). agnes, or the “sudden aging” suit, as Joseph Coughlin, the founder and director of the AgeLab describes it, includes yellow glasses, which convey a sense of the yellowing of the ocular lens that comes with age; a boxer’s neck harness, which mimics the diminished mobility of the cervical spine; bands around the elbows, wrists, and knees to simulate stiffness; boots with foam padding to produce a loss of tactile feedback; and special gloves to “reduce tactile acuity while adding resistance to finger movements.”

Slowly pulling on the aging suit and then standing up—it looks a bit like one of the spacesuits that the Russian cosmonauts wore—you’re at first conscious merely of a little extra weight, a little loss of feeling, a small encumbrance or two at the extremities. Soon, though, it’s actively infuriating. The suit bends you. It slows you. You come to realize what makes it a powerful instrument of emotional empathy: every small task becomes effortful. “Reach up to the top shelf and pick up that mug,” ...requires more attention than you expected. You reach for the mug instead of just getting it. Your emotional cast, as focussed task piles on focussed task, becomes one of annoyance; you acquire the same set-mouthed, unhappy, watchful look you see on certain elderly people on the subway. The concentration that each act requires disrupts the flow of life, which you suddenly become aware is the happiness of life, the ceaseless flow of simple action and responses, choices all made simultaneously and mostly without effort. Happiness is absorption, and absorption is the opposite of willful attention.

The AgeLab is designed to alleviate this progression. It exists to encourage and incubate new technologies and products and services for an ever-larger market of aging people....the AgeLab swiftly discovered that engineering and promoting new products and services specially designed for the expanding market of the aged is a good way of going out of business. Old people will not buy anything that reminds them that they are old. They are a market that cannot be marketed to. In effect, to accept help in getting out of the suit is to accept that we’re in the suit for life. We would rather suffer because we’re old than accept that we’re old and suffer less.

The AgeLab has rediscovered the eternal truth that identity matters to us far more than utility. The most effective way of comforting the aged, the researchers there find, is through a kind of comical convergence of products designed by and supposedly for impatient millennials, which secretly better suit the needs of irascible boomers. The best hearing aids look the most like earbuds. The most effective PERS (personal-emergency-response system) device is an iPhone or an Apple Watch app.

It’s the failure of industry and engineering to address the actual problems of aging—the problems summed up by the aggravations of the agnes suit—that makes Coughlin impatient with scientific speculations about extending life. “We’ve already extended life! What we need is not to put off death a little longer but to write a new narrative of aging as it could be.”

The second section of the article describes several approaches that contest the classic explanation of why we age:

Once we have passed reproductive age, the genes can get sloppy about copying, allowing mutations to accumulate, because natural selection no longer cares. And so things fall apart. The second law of thermodynamics gets us all in the end. The car or the Cuisinart works for a decade, breaks down, and can’t be fixed; rust never sleeps, and we do.

Contra this view:

...in certain genetic labs at Harvard, the chairs and seals and exaptated services of the AgeLab are regarded as mere Band-Aids on the problem to be solved. Here, there are whispers of undying yeast, tales of eternally young mice, rumors of rejuvenated dogs, and scientists who stubbornly insist that age is an illness to be treated like any other...Perhaps aging is not a condition to be managed but a mistake to be fixed.

However,

To pass from the Harvard rejuvenators to the laboratory of Patrick Hof, at the Icahn School of Medicine at Mount Sinai, in Manhattan, is to sober up a little. Here, there is talk not of imminent innovation but of discouragingly minute work proceeding on many slow-moving fronts over decades. Where the Harvard crowd see quick fixes in the near future, Hof, an expert on the neuronal underpinnings of aging and Alzheimer’s, sees the exposure of ever more confounding complexity.

In conclusion...

As you take off the agnes suit—piece by piece; the boots and then the wrist weights and the impeding gloves—the feeling is disconcerting. It’s the return of flow, the feeling of choice and possibility as you begin to move again through the world, that makes you recall that what it is to be young is not to be in a state of ecstasy but merely to be unimpeded, to be in the world without having undue consciousness of your own muscle and bone within it. It’s the same thing we experience when we remove a splinter from our foot; what we get is not happiness in a positive sense but a return to not having to think about the prison and the fact of our flesh. We forget our insides, and fold ourselves back out.

The true condition of youth is the physical ability to forget ourselves. A friend who is still creative in his eighties points out what he calls the geriatric possessive: people past eighty, he says, are expected to say, “I’m going to take my bath,” “I’m going to take my walk.” We can counterpoise that to the pediatric possessive: “You’re going to take your bath,” “It’s time for your nap.” Only in midlife do we feel secure enough to enumerate actions as existing individually outside our possession of them: “I’m going to take a bath,” “I’m going to take a nap.” A bath and a nap exist, briefly, outside our possession of them—they’re just around for the taking, we suppose, and always will be.

We may indeed already be converging as a population — irascible millennials who feel dated at twenty-five and determinedly upbeat boomers who insist on feeling young at seventy — on a single American age, a kind of shared perpetual middleness, where we will dye our hair and take our pills and suddenly collapse in the midst of the dance. Right now, we live well, and then we don’t live well, and then we die. The most that science seems to offer us is this: We’ll live well, and then we’ll die.

With the rise of Trump, the fall of racial prejudice?

Stanley-Becker points to a fascinating study by Hopkins and Washington. Their abstract:

In his campaign and first few years in office, Donald Trump consistently defied contemporary norms by using explicit, negative rhetoric targeting ethnic/racial minorities. Did this rhetoric lead white Americans to express more prejudiced views of African Americans or Hispanics, whether through the normalization of prejudice or other mechanisms? We assess that question using a 13-wave panel conducted with a population-based sample of Americans between 2008 and 2018. We find that via most measures, white Americans' expressed anti-Black and anti-Hispanic prejudice declined after the 2016 campaign and election, and we can rule out even small increases in the expression of prejudice. These results suggest the limits of racially charged rhetoric's capacity to heighten prejudice among white Americans overall. They also indicate that prejudice can behave like an issue attitude: rather than being a fixed predisposition, prejudice can respond thermostatically to changing presidential rhetoric and policy positions.

Stanley-Becker quotes Hopkins:

...it’s quite conceivable that Trump has simultaneously galvanized a small number of highly prejudiced white Americans while also pushing millions more to affirm that they are not as prejudiced.

Hopkins said his discovery is not out of step with other assessments. In fact, his conclusions are in line with recent scholarship suggesting that bias, both implicit and explicit, has declined when it comes to race and sexual orientation, though prejudice has remained steady regarding people with disabilities and actually increased regarding obesity.

The recent scholarship Hopkins references is work from Banaji's group:

Using 4.4 million tests of implicit and explicit attitudes measured continuously from an Internet population of U.S. respondents over 13 years, we conducted the first comparative analysis using time-series models to examine patterns of long-term change in six social-group attitudes: sexual orientation, race, skin tone, age, disability, and body weight. Even within just a decade, all explicit responses showed change toward attitude neutrality. Parallel implicit responses also showed change toward neutrality for sexual orientation, race, and skin-tone attitudes but revealed stability over time for age and disability attitudes and change away from neutrality for body-weight attitudes. These data provide previously unavailable evidence for long-term implicit attitude change and stability across multiple social groups; the data can be used to generate and test theoretical predictions as well as construct forecasts of future attitudes.

Blame the liberals for unlivable cities!

An excellent article by Farhad Manjoo, focusing on San Francisco's affordable housing crisis. Some clips:

Just look at San Francisco, Nancy Pelosi’s city. One of every 11,600 residents is a billionaire, and the annual household income necessary to buy a median-priced home now tops $320,000. Yet the streets there are a plague of garbage and needles and feces, and every morning brings fresh horror stories from a “Black Mirror” hellscape: Homeless veterans are surviving on an economy of trash from billionaires’ mansions. Wealthy homeowners are crowdfunding a legal effort arguing that a proposed homeless shelter is an environmental hazard.

And there is no end in sight to such crushing success. At every level of government, our representatives, nearly all of them Democrats, prove inadequate and unresponsive to the challenges at hand. Witness last week’s embarrassment, when California lawmakers used a sketchy parliamentary maneuver to knife Senate Bill 50, an ambitious effort to undo restrictive local zoning rules and increase the supply of housing.

It was another chapter in a dismal saga of Nimbyist urban mismanagement that is crushing American cities. Not-in-my-backyardism is a bipartisan sentiment, but because the largest American cities are populated and run by Democrats — many in states under complete Democratic control — this sort of nakedly exclusionary urban restrictionism is a particular shame of the left.

Democrats on the 2020 presidential trail rarely mention their ideas for housing affordability, an issue eating American cities alive.

What Republicans want to do with I.C.E. and border walls, wealthy progressive Democrats are doing with zoning and Nimbyism. Preserving “local character,” maintaining “local control,” keeping housing scarce and inaccessible — the goals of both sides are really the same: to keep people out.

Educating liberals about white privilege doesn't make them more empathetic.

Cooley et al. find that people with socially liberal views on the major political issues are actually less likely to empathize with a poor white person’s plight after being given a reading on white privilege (see also the article by Jilani that points to this work):

White privilege lessons are sometimes used to increase awareness of racism. However, little research has investigated the consequences of these lessons. Across 2 studies (N = 1,189), we hypothesized that White privilege lessons may both highlight structural privilege based on race, and simultaneously decrease sympathy for other challenges some White people endure (e.g., poverty)—especially among social liberals who may be particularly receptive to structural explanations of inequality. Indeed, both studies revealed that while social liberals were overall more sympathetic to poor people than social conservatives, reading about White privilege decreased their sympathy for a poor White (vs. Black) person. Moreover, these shifts in sympathy were associated with greater punishment/blame and fewer external attributions for a poor White person’s plight. We conclude that, among social liberals, White privilege lessons may increase beliefs that poor White people have failed to take advantage of their racial privilege—leading to negative social evaluations.

Benefits of a period of exercise persist after 10 years.

Gretchen Reynolds points to a study by Johnson et al. showing long term effects of an experiment conducted from 1998 to 2003, in which overweight volunteers between 40 and 60 were divided into control (inactive), moderate walking), and vigorous (jogging) exercise groups that completed three sessions of their assigned workout each week for eight months. Health markers (aerobic fitness, blood pressure, insulin sensitivity and waist circumference) improved in the exercise but not the control groups. Experimenters were able to get in touch with many subjects 10 years later and found:

Most of the men and women from the control group, who had not exercised 10 years before, had larger waistlines now, while the exercisers displayed little if any middle-aged spread compared to their decade-earlier selves.

Those from the control group also were less fit now. Most had lost about 10 percent of their aerobic capacity, which is typical of the declines seen after about age 40, when most of us will lose about 1 percent of our fitness annually.

But those men and women who had exercised vigorously for eight months during the original experiment retained substantially more fitness. On average, their aerobic capacity had fallen by only about 5 percent, compared to when they had joined the Strride study, and those few who reported still exercising at least four times a week were more fit now than they had been a decade before.

Interestingly, those earlier experimental volunteers who had walked — meaning their exercise had been moderate, not intense — did not seem to have enjoyed the same lasting fitness benefits as those who had exercised more vigorously. Most of them had shed about 10 percent of their aerobic capacity during the past decade, much like the controls.

On the other hand, they showed surprisingly persistent improvements in their metabolic health, more so than among the intense exercisers. The walkers from 10 years ago still had healthier blood pressures and insulin sensitivity than they had had before joining the earlier experiment, even if they rarely exercised now. They had also had relatively healthier metabolisms than the men and women who had exercised intensely all those years before.

A Sunday Afternoon Musicale - Bridges and Mendelssohn

This post falls in the 'random curious stuff' of the MindBlog title above. I want to share some of my current musical efforts with MindBlog readers. When MindBlog began in 2016 I started to share with readers some of the videos made at Sunday afternoon musical/social events at my 1860 schoolhouse/residence in Madison Wisconsin. I'm now living full time in Austin Texas, and have been fortunate to be able form a piano trio with two accomplished musicians, violinist Andrea Gore and Cellist Karen Foster Cason. Andrea hosted a Musicale this past Sunday at her beautiful home built on the banks of a creek running into Lake Travis. The pictures show our trio, and the natural grotto photographed from the deck of the house. I embed a rehearsal video of the Mendelssohn Allegro and give links to rehearsal videos of the rest of the program (I wish I had recorded the coherence and precision of the event itself). The Mendelssohn Allegro and Finale are the most pyrotechnical of the offerings.

Program for the Sunday, May 19, 1:00 Musicale at Awalt

Frank Bridge (1879-1941)
Miniatures for Violin, Violoncello, & Piano
4. Romance
5. Intermezzo
6. Saltarello

Felix Mendelssohn (1809-1847) Piano Trio No. 2 in D minor, Op. 66
1. Allegro energico e con fuoco
2. Andante espressivo
3. Scherzo: Molto allegro quasi presto
4. Finale: Allegro appassionato

Andrea Gore, Violin
Karen Foster Cason, Cello
Deric Bownds, Piano

Are rich people really less generous than poor people?

Here is a ‘fact’ (that rich people are less generous than poor people) that I had locked into mind that turns out to be wrong. They are not less generous, contra the findings of an often cited 2015 landmark study. From Schmukle et al.:

Significance

Are the rich less generous than the poor? Results of studies on this topic have been inconsistent. Recent research that has received widespread academic and media attention has provided evidence that higher income individuals are less generous than poorer individuals only if they reside in a US state with comparatively large economic inequality. However, in large representative datasets from the United States (study 1), Germany (study 2), and 30 countries (study 3), we did not find any evidence for such an effect. Instead, our results suggest that the rich are not less generous than the poor, even when economic inequality is large. This result has implications for contemporary debates on what increasing inequality in resource distributions means for modern societies.

Abstract

A landmark study published in PNAS [Côté S, House J, Willer R (2015) Proc Natl Acad Sci USA 112:15838–15843] showed that higher income individuals are less generous than poorer individuals only if they reside in a US state with comparatively large economic inequality. This finding might serve to reconcile inconsistent findings on the effect of social class on generosity by highlighting the moderating role of economic inequality. On the basis of the importance of replicating a major finding before readily accepting it as evidence, we analyzed the effect of the interaction between income and inequality on generosity in three large representative datasets. We analyzed the donating behavior of 27,714 US households (study 1), the generosity of 1,334 German individuals in an economic game (study 2), and volunteering to participate in charitable activities in 30,985 participants from 30 countries (study 3). We found no evidence for the postulated moderation effect in any study. This result is especially remarkable because (i) our samples were very large, leading to high power to detect effects that exist, and (ii) the cross-country analysis employed in study 3 led to much greater variability in economic inequality. These findings indicate that the moderation effect might be rather specific and cannot be easily generalized. Consequently, economic inequality might not be a plausible explanation for the heterogeneous results on the effect of social class on prosociality.

Like the emperor’s new clothes, DNA kits are a tailored illusion

I recommend reading this article by George Estreich. Here are a few clips:

Most people remember the emperor: a vain ruler, swindled into paying for a nonexistent magical garment, parades in public, only to be embarrassed by a little boy. To me, the story is really about the swindling tailors. Audacious, imaginative, their true product is a persuasive illusion, one keyed to the vulnerabilities of their target audience. In contemporary terms, the story is about marketing; and as such, the tale is tailor-made for an examination of genetic ancestry tests, because these too are sold with expert persuasion, with promises woven from our hopes, our fears, and the golden thread of DNA.

With these new tests, as in Hans Christian Andersen’s 19th-century tale, a gap yawns between the promise and the reality – and now and then, as in the story, someone says so in the public square. For example, when Phil Rogers, a reporter in Chicago, tried out home DNA test kits from competing companies last year, he discovered contradictory results. So did the Canadian reporter Charlsie Agro and her twin sister Carly, who mailed spit samples to 23andMe, FamilyTreeDNA, AncestryDNA, MyHeritage and LivingDNA. As with Rogers, the companies gave different histories – Balkan ancestry, for example, ranged from 14 to 61 per cent – but 23andMe actually reported different scores for each twin. (According to the company, Charlsie has French and German ancestors, while Carly does not.)

The tests are sold with variations on a single pitch: find your story. The companies don’t mention that the story might shade into fiction, or that stories can conflict. The evolutionary geneticist Mark Thomas at University College London has dismissed ancestry testing as ‘genetic astrology’, but it could be as useful to think of it as genetic gossip: a rumoured past that, like most rumours, is at least partly true.

Chasing his dreams of status and power, the emperor misses the swindle: the ‘weavers’ make off with tangible wealth, while the emperor receives nothing. The entire performance is a masterful misdirection, a distraction from the truth of the exchange. In the same way, the promises of discovering identity and the genealogical past are a misdirection: the real exchange takes place offstage, with drug companies and others paying for access to the data that customers actually pay to give. Once it’s given, customers are vulnerable to future data breaches (and you can’t, at this date at least, change your genome), and they aren’t guaranteed compensation for any profits the data might lead to.

Father's physical activity directly enhances offspring's brain physiology and cognition.

Experiments on mice suggest that human kids of athletic fathers might have more smarts than kids of couch potatoes. From McGreevy et al.:

Significance

Physical exercise is well known for its positive effects on general health (specifically, on brain function and health), and some mediating mechanisms are also known. A few reports have addressed intergenerational inheritance of some of these positive effects from exercised mothers or fathers to the progeny, but with scarce results in cognition. We report here the inheritance of moderate exercise-induced paternal traits in offspring’s cognition, neurogenesis, and enhanced mitochondrial activity. These changes were accompanied by specific gene expression changes, including gene sets regulated by microRNAs, as potential mediating mechanisms. We have also demonstrated a direct transmission of the exercise-induced effects through the fathers’ sperm, thus showing that paternal physical activity is a direct factor driving offspring’s brain physiology and cognitive behavior.

Abstract

Physical exercise has positive effects on cognition, but very little is known about the inheritance of these effects to sedentary offspring and the mechanisms involved. Here, we use a patrilineal design in mice to test the transmission of effects from the same father (before or after training) and from different fathers to compare sedentary- and runner-father progenies. Behavioral, stereological, and whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult hippocampal gene expression profile. These results demonstrate the inheritance of exercise-induced cognition enhancement through the germline, pointing to paternal physical activity as a direct factor driving offspring’s brain physiology and cognitive behavior.

Ready to pounce - Cat smarts get some attention

I live in a symbiotic relationship with my two Abyssinian cats, and so was gratified, given that canine social cognition is the subject of dozens of scientific papers, to see that feline cognition is beginning to get more attention. One simple reason for the difference is that dogs want to please humans and cooperate with experimenters, while cats could generally care less, and after a few trials will walk away from earnest efforts to engage their responses. When a human points at something, a chimp will not react, but a dog, like a human toddler, knows to look at the same thing. Turns out that cats do the same thing, they will trot over to a bowl that a human points to. It is turning out that cats match dogs in many tests of social smarts. Alas, I'm going to show you a cat video... not of some adorable feline faux pas, but of behavioral work being done with cats:



And, since I'm showing cat pictures, I can't resist introducing you to Abyssinians Marvin and Melvin, shown napping while I'm driving between Madison WI and Austin TX.

Want to escape your liberal bubble? Try this.....

I have a recommendation for MindBlog readers like myself who are concerned about their immersion in the liberal bubble of the New York Times, Washington Post and the numerous sarcastic evening show commentators (Colbert, Maher, Maddow, Noah, etc.). The media (alas, like scientific reality in general!) does indeed have a liberal bias. I'm now finding a crystallized antithesis to my bubble in the American Greatness website, whose daily email screeds I have subscribed to after reading an Op-Ed piece in the NY Times by its publisher and editor Chris Buskirk. To note only three of the twelve pieces in last Thursday's email: Democrats’ Collapse Could Happen Quickly , Yes,Christians Can Support Trump Without Risk to Their Witness , and  Why the Left Mocks the Bible . A clip from the last of these, a telling piece:

...on virtually every important value in life, the left and the Bible are diametrically opposed...

The biblical view is that people are not basically good. Evil, therefore, comes from within human nature. For the left, human nature is not the source of evil. Capitalism, patriarchy, poverty, religion, nationalism or some other external cause is the source of evil.

The biblical view is that nature was created for man. The left-wing view is that man is just another part of nature.

The biblical view is that man is created in the image of God and, therefore, formed with a transcendent, immaterial soul. The left-wing view—indeed, the view of all secular ideologies—is that man is purely material, another assemblage of stellar dust.

Relevant to humans being 'born in sin' I hope to do a post soon on a book I just finished, Nicholas Christakis' Magnum Opus “Blueprint: The Evolutionary Origins of a Good Society”. This book, like Pinker's "Enlightenment Now" , the subject of previous MindBlog posts, paints a more benign picture of desirable human traits that have evolved to make society possible.

MindBlog Changes

I want to explain to readers who check MindBlog daily why the drumbeat of a post each weekday (4,700 posts over the past 13 years) has stopped. My 78th year starts next week, and performative professor Deric has decided to spend more time doing other things, to try a few new tricks. I will continue to occasionally post on interesting material I encounter.

The Case for Doing Nothing

An article by Olga Mecking fits so well with my increasing allergic reaction to making myself busy all the time that I have to pass on a few edited and rearranged clips:

Perhaps it’s time to stop all this busyness. Being busy...is rarely the status indicator we’ve come to believe it is...There’s a way out...and it’s not more mindfulness, exercise or a healthy diet... What we’re talking about is … doing nothing. Or, as the Dutch call it, niksen...being like a car whose engine is running but isn’t going anywhere...coming to a moment with no plan other than just to be.

...the idea of niksen is to take conscious, considered time and energy to do activities like gazing out of a window or sitting motionless...permission granted to spend the afternoon just hanging out...daydreaming and idleness let the mind search for its own stimulation...counterintuitively, idleness can be a great productivity tool..it takes you out of your mind, and then you see things clearly after a while...it makes us more creative, better at problem-solving, better at coming up with creative ideas......For that to happen, though, total idleness is required.

...don’t get discouraged if you don’t catch on immediately to the benefits of idleness...like beginning a new workout routine: At first, you might get sore, but after a while, you’ll find yourself in this moment of "Oh, this feels fantastic.” Keep your devices out of reach so that they’ll be more difficult to access, and turn your home into a niksen-friendly area. Add a soft couch, a comfy armchair, a few cushions or just a blanket. Orient furniture around a window or fireplace rather than a TV.

Same-sex marriage legalization reduced implicit and explicit antigay bias

Interesting work from Ofosu et al. shows how government legislation can inform individuals’ attitudes, even when these attitudes may be deeply entrenched and socially and politically volatile.:

The current research tested whether the passing of government legislation, signaling the prevailing attitudes of the local majority, was associated with changes in citizens’ attitudes. Specifically, with ∼1 million responses over a 12-y window, we tested whether state-by-state same-sex marriage legislation was associated with decreases in antigay implicit and explicit bias. Results across five operationalizations consistently provide support for this possibility. Both implicit and explicit bias were decreasing before same-sex marriage legalization, but decreased at a sharper rate following legalization. Moderating this effect was whether states passed legislation locally. Although states passing legislation experienced a greater decrease in bias following legislation, states that never passed legislation demonstrated increased antigay bias following federal legalization. Our work highlights how government legislation can inform individuals’ attitudes, even when these attitudes may be deeply entrenched and socially and politically volatile.

Why are some people more anxious than others? Brain correlates of trait anxiety.

Why does trait anxiety (the stable tendency to attend to, experience, and report negative emotions such as fears, worries, and anxiety across many situations) vary between individuals? Berry et al. have measured self-reported trait anxiety in healthy adults, examining its relationships with brain dopamine function (Most anxiolytic drugs target serotonergic and GABAergic neurotransmitter systems) and also examining functional connectivity within circuits implicated in anxiety regulation. This enabled them to probe the neural substrates of individual differences.

  Significance Statement

It is common wisdom that individuals vary in their baseline levels of anxiety. We all have a friend or colleague we know to be more “tightly wound” than others, or, perhaps, we are the ones marveling at others' ability to “just go with the flow.” Although such observations about individual differences within nonclinical populations are commonplace, the neural mechanisms underlying normal variation in trait anxiety have not been established. Using multimodal brain imaging in humans, this study takes initial steps in linking intrinsic measures of neuromodulator release and functional connectivity within regions implicated in anxiety disorders. Our findings suggest that in healthy adults, higher levels of trait anxiety may arise, at least in part, from reduced dopamine neurotransmission.

Abstract

Trait anxiety has been associated with altered activity within corticolimbic pathways connecting the amygdala and rostral anterior cingulate cortex (rACC), which receive rich dopaminergic input. Though the popular culture uses the term “chemical imbalance” to describe the pathophysiology of psychiatric conditions such as anxiety disorders, we know little about how individual differences in human dopamine neurochemistry are related to variation in anxiety and activity within corticolimbic circuits. We addressed this issue by examining interindividual variability in dopamine release at rest using [¹¹C]raclopride positron emission tomography (PET), functional connectivity between amygdala and rACC using resting-state functional magnetic resonance imaging (fMRI), and trait anxiety measures in healthy adult male and female humans. To measure endogenous dopamine release, we collected two [¹¹C]raclopride PET scans per participant. We contrasted baseline [¹¹C]raclopride D2/3 receptor binding and D2/3 receptor binding following oral methylphenidate administration. Methylphenidate blocks the dopamine transporter, which increases extracellular dopamine and leads to reduced [¹¹C]raclopride D2/3 receptor binding via competitive displacement. We found that individuals with higher dopamine release in the amygdala and rACC self-reported lower trait anxiety. Lower trait anxiety was also associated with reduced rACC–amygdala functional connectivity at baseline. Further, functional connectivity showed a modest negative relationship with dopamine release such that reduced rACC–amygdala functional connectivity was accompanied by higher levels of dopamine release in these regions. Together, these findings contribute to hypodopaminergic models of anxiety and support the utility of combining fMRI and PET measures of neurochemical function to advance our understanding of basic affective processes in humans.

[11C]

Is Superintelligence Impossible?

Andy Clarke does an interesting and concise commentary on a discussion between Daniel Dennett and David Chalmers. I pass on the final two paragraphs of Clark's comments and suggest you read the whole piece.

I think we can divide the space of possible AI minds into two reasonably distinct categories. One category comprises the “passive AI minds” that seemed to be the main focus of the Chalmers-Dennett exchange. These are driven by large data sets and optimize their performance relative to some externally imposed choice of “objective function” that specifies what we want them to do—win at GO, or improve paperclip manufacture. And Dennett and Chalmers are right—we do indeed need to be very careful about what we ask them to do, and about how much power they have to implement their own solutions to these pre-set puzzles.

The other category comprises active AIs with broad brush-strokes imperatives. These include Karl Friston’s Active Inference machines. AI’s like these spawn their own goals and sub-goals by environmental immersion and selective action. Such artificial agents will pursue epistemic agendas and have an Umwelt of their own. These are the only kind of AIs that may, I believe, end up being conscious of themselves and their worlds—at least in any way remotely recognizable as such to us humans. They are the AIs who could be our friends, or who could (if that blunt general imperative was played out within certain kinds of environment) become genuine enemies. It is these radicalized embodied AIs I would worry about most. At the same time (and for the same reasons) I’d greatly like to see powerful AIs from that second category emerge. For they would be real explorations within the vast space of possible minds.

Digital addiction and the attention economy.

Jia Tolentino's "What It Takes to Put Your Phone Away" is a broad essay on our digital addictions that focuses on two recent books: Cal Newport's “Digital Minimalism: Choosing a Focused Life in a Noisy World” and Jenny Odell's “How to Do Nothing: Resisting the Attention Economy." I strongly recommend that you read it. I am going to resist the impulse to pass on many choice clips of text, limiting myself to two:

Odell elegantly aligns the crisis in our natural world and the crisis in our minds: what has happened to the natural world is happening to us, she contends, and it’s happening on the same soon-to-be-irreparable scale. She sees “little difference between habitat restoration in the traditional sense and restoring habitats for human thought”; both are endangered by “the logic of capitalist productivity.” She believes that, by constantly disclosing our needs and desires to tech companies that sift through our selfhood in search of profit opportunities, we are neglecting, even losing, our mysterious, murky depths—the parts of us that don’t serve an ulterior purpose but exist merely to exist. The “best, most alive parts” of ourselves are being “paved over by a ruthless logic of use.”

On the monetization of attention:

Legislators might succeed in granting citizens more control over the data that they generate by using the Internet, but social-media companies will, presumably, continue to treat their users like little countries that can be strip-mined to make other people rich...We remain attached to these technologies in a way that is clearly affecting the health of the body politic. Newport insists that our Internet-fuelled lack of mental peace and quiet is a better explanation for the current wave of American anxiety than “the latest crisis—be it the recession of 2009 or the contentious election of 2016.”

A bit of digital detox - rehearsing a Mendelssohn Piano Trio

I have been fortunate to find in Austin TX two accomplished string players, violinist Andrea Gore and cellist Karen Foster Cason, who join me in sight reading interesting piano trios. We have decided to work up a few of the pieces we like to do for a house concert in late May, - a musical/social occasion of the sort I used to do in the 1860 stone schoolhouse that was the living room of my Twin Valley Road residence in Madison Wisconsin. I thought I would pass on to MindBlog readers a bit of our rehearsal this past Thursday, working on a Mendelssohn piano trio.

The "digital detox" phrase in this post's title is a clip from Jia Tolentino's recent New Yorker Article "What It Takes to Put Your Phone Away." I'm very much in the mood these days to get away from the "invasion of your cognitive landscape" that it describes and that I have permitted by being open to so many digital input streams as I spend a large fraction of my days hovering over screen and keyboard.

I find that the exercise of playing music is an antidote to this malaise, and I want to spend more time doing it. Don't be surprised if MindBlog posts become less frequent. Anyway, here is the 1st movement of the Mendelssohn Piano Trio No. 2 in C Minor, in a video recording done with my iPhone XS Max with a Shure condenser microphone plugged into its USB port:

Bringing dead brains back to life.

Work by Vrselja et al. on restoring brain function in pigs four hours after death has been extensively covered by the popular press. I want to pass on the abstract to their paper, and then one clip that shows how far away the recovery observed is from actually restoring brain function.

The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo normothermic conditions up to four hours post-mortem. We have developed an extracorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery from anoxia, reduces reperfusion injury, prevents oedema, and metabolically supports the energy requirements of the brain. With this system, we observed preservation of cytoarchitecture; attenuation of cell death; and restoration of vascular dilatory and glial inflammatory responses, spontaneous synaptic activity, and active cerebral metabolism in the absence of global electrocorticographic activity. These findings demonstrate that under appropriate conditions the isolated, intact large mammalian brain possesses an underappreciated capacity for restoration of microcirculation and molecular and cellular activity after a prolonged post-mortem interval.

This beautiful work shows that the brain has a much greater capacity for restoration that had been realized. The authors were able to obtain intracellular recordings from hippocampus pyramidal cells. However:

Monitoring of electrical activity from the dorsal surface of the brain using clinical-grade surface grid electrodes and electrocorticography (ECoG; also known as intracranial electroencephalography, EEG) revealed that spontaneous global activity did not reemerge and that ECoG activity was isoelectric throughout BEx perfusion. This indicates that the organization and/or summation of synaptic activity of individual neurons was inadequate to elicit detectable network activity as assessed by ECoG.

Factfulness - Rosling's instinctual mental errors - Destiny, Single Perspective, Blame, Urgency

This is the final installment of several posts for my own benefit - making brief clips from the Rosling "Factfullness" book to encapsulate what he calls our 10 'basic instincts' - instinctual mental errors that we make - hoping this exercise will imprint them in my feeble memory and make me less likely to perform some of the mental errors he describes.

The Destiny Instinct (Chapter 7) - Many things (including people, countries, religions, and cultures) appear to be constant just because the change is happening slowly. Remember that even small, slow changes gradually add up to big changes. To control the destiny instinct, remember slow change is still change. Keep track of gradual improvements. A small change every year can translate to a huge change over decades. Update your knowledge. Some knowledge goes out of date quickly. Technology, countries, societies, cultures, and religions are constantly changing. Talk to Grandpa. If you want to be reminded of how values have changed, think about your grandparents’ values and how they differ from yours. Collect examples of cultural change. Challenge the idea that today’s culture must also have been yesterday’s, and will also be tomorrow’s.

The Single Perspective Instinct (Chapter 8) - Recognize that a single perspective can limit your imagination, and remember that it is better to look at problems from many angles to get a more accurate understanding and find practical solutions. To control the single perspective instinct, get a toolbox, not a hammer. Test your ideas. Don’t only collect examples that show how excellent your favorite ideas are. Have people who disagree with you test your ideas and find their weaknesses. Don’t claim expertise beyond your field: be humble about what you don’t know. Be aware too of the limits of the expertise of others. If you are good with a tool, you may want to use it too often. If your favorite idea is a hammer, look for colleagues with screwdrivers, wrenches, and tape measures. Be open to ideas from other fields. The world cannot be understood without numbers, and it cannot be understood with numbers alone. Love numbers for what they tell you about real lives. Beware of simple ideas and simple solutions. History is full of visionaries who used simple utopian visions to justify terrible actions. Welcome complexity. Combine ideas. Compromise. Solve problems on a case-by-case basis.

The Blame Instinct (Chapter 9) - Recognize when a scapegoat is being used and remember that blaming an individual often steals the focus from other possible explanations and blocks our ability to prevent similar problems in the future. To control the blame instinct, resist finding a scapegoat. Look for causes, not villains. When something goes wrong don’t look for an individual or a group to blame. Accept that bad things can happen without anyone intending them to. Instead spend your energy on understanding the multiple interacting causes, or system, that created the situation. Look for systems, not heroes. When someone claims to have caused something good, ask whether the outcome might have happened anyway, even if that individual had done nothing. Give the system some credit.

The Urgency Instanct (Chapter 10) - Recognize when a situation feels urgent and remember that it rarely is. To control the urgency instinct, take small steps. Take a breath. When your urgency instinct is triggered, your other instincts kick in and your analysis shuts down. Ask for more time and more information. It’s rarely now or never and it’s rarely either/or. Insist on the data. If something is urgent and important, it should be measured. Beware of data that is relevant but inaccurate, or accurate but irrelevant. Only relevant and accurate data is useful. Beware of fortune-tellers. Any prediction about the future is uncertain. Be wary of predictions that fail to acknowledge that. Insist on a full range of scenarios, never just the best or worst case. Ask how often such predictions have been right before. Be wary of drastic action. Ask what the side effects will be. Ask how the idea has been tested. Step-by-step practical improvements, and evaluation of their impact, are less dramatic but usually more effective.