Wednesday, October 25, 2006
"Special K" not just a party drug
The club drug K may be useful for something besides the psychedelic high of going "down the K-hole." A brief review by Check in Nature summarizes evidence that Ketamine, which works on NMDA glutamate receptors, may find a legitimate use as an antidepressant. A recent article by Zarate et al. shows that robust and rapid antidepressant effects result from a single intravenous dose of ketamine (0.5 mg/kg); onset occurrs within 2 hours postinfusion and continues to remain significant for 1 week.