Brain correlates of the muting of our emotions as we age.

 (This is a re-post of the MindBlog post of Oct. 1, 2008, as relevant today as then.)

My boyfriend in the early 19980’s was a pharmacy graduate student whose t-shirt read “Drugs are my life.” If I were to wear such a t-shirt now it would read “Hormones and neurotransmitters are my life.” I increasingly feel that all this verbal stuff we do - chattering in person or in the electronic ether, writing blogs, etc. - is a superficial veneer, noise on top of what is really running the show, which is the waxing and waning of hormones and neurotransmitters directed by an “it”, a martian inside us utterly running its own show. These compounds regulate our assertiveness versus passivity , our trust versus mistrust, our anxiety versus calm, our pleasure during antipication and reward. (They function, respectively, in neural systems that use testosterone, oxytocin, adrenaline, and dopamine.). The swings in these systems become less dramatic as we 'mellow' with aging.

Dreher et al. have published an interesting bit of work that deals specifically with the muting of the intensity of the pleasures we feel during anticipation and reward, in their article on “Age-related changes in midbrain dopaminergic regulation of the human reward system.” Their data show what is going on as we experience less excitement at opening a present when we are 60 than when we are 10 years old. There are changes in the brain's production of dopamine, which plays a central role in our reward system, as well as in which parts of the brain respond to it, and by how much they respond. (a recent brief article on dopamine and the reward system of the brain is here.) Here is their abstract, followed by a figure from the paper.

The dopamine system, which plays a crucial role in reward processing, is particularly vulnerable to aging. Significant losses over a normal lifespan have been reported for dopamine receptors and transporters, but very little is known about the neurofunctional consequences of this age-related dopaminergic decline. In animals, a substantial body of data indicates that dopamine activity in the midbrain is tightly associated with reward processing. In humans, although indirect evidence from pharmacological and clinical studies also supports such an association, there has been no direct demonstration of a link between midbrain dopamine and reward-related neural response. Moreover, there are no in vivo data for alterations in this relationship in older humans. Here, by using 6-[18F]FluoroDOPA (FDOPA) positron emission tomography (PET) and event-related 3T functional magnetic resonance imaging (fMRI) in the same subjects, we directly demonstrate a link between midbrain dopamine synthesis and reward-related prefrontal activity in humans, show that healthy aging induces functional alterations in the reward system, and identify an age-related change in the direction of the relationship (from a positive to a negative correlation) between midbrain dopamine synthesis and prefrontal activity. These results indicate an age-dependent dopaminergic tuning mechanism for cortical reward processing and provide system-level information about alteration of a key neural circuit in healthy aging. Taken together, our findings provide an important characterization of the interactions between midbrain dopamine function and the reward system in healthy young humans and older subjects, and identify the changes in this regulatory circuit that accompany aging.


Legend (click on figure to enlarge). Statistical t maps of the within-groups effects in the different phases of the reward paradigm. (A) (Left) Main effect of anticipating reward in young subjects during the delay period, showing activation in the left intraparietal cortex, ventral striatum, caudate nucleus, and anterior cingulate cortex. (Right) Main effect of anticipating reward in older subjects during the delay period, showing activation in the left intraparietal cortex only. The glass brain and the coronal slice indicate that no ventral striatum activity was observed in older subjects. (B) (Left) Main effect of reward receipt in young subjects at the time of the rewarded outcome showing activation in a large bilateral prefronto-parietal network. (Right) Main effect of reward receipt in older subjects at the time of the rewarded outcome showing bilateral prefronto-parietal activation.

For a tranquil start to your week, Debussy with flowers

In my slow cruising through old MindBlog posts, I just came across the following post from Monday, March 2, 2009.....perhaps a faintly calming antidote to our current uncertain times. Enjoy:

I got an email from the fellow who made this video asking if he could use my YouTube videorecording of the Debussy Reverie. I said 'sure, go ahead'.... I'm not too keen on the electronic 'enhancements' he added to my basic piano track to make the first half of the video, but here it is...

Some rambling on "Selves" and "Purpose"

I've decided to re-post the following text from a MindBlog post of Oct. 9, 2007, which I found while cruising old posts. A bit terse and disjointed, but I like the general sentiments.

Self conscious "Purpose" of the sort we humans experience, in the service of crafting new political movements or environments, is an evolved psychology that (sometimes) helps pass on our genes, and requires our distinctively human self reflective "I". Our behavior and that of other animals also reflects a kind of purpose that has been formed by our evolutionary and developmental history. In other animals such behaviors are acted out on the cusp of an eternal present - there is no evidence that they "know that they know" in the way that we can.

Both modern neuroscience and Buddhist psychology inform us that the self and the purpose that each of us experiences is an illusion or confabulation of our brains - hopefully a useful one - whose utility is tested by how it enhances our energy and individual survival. This 'illusion' is a powerful instrument of downward causation, regulating our psychological, immune, neuro-endocrine robustness.

What is especially amazing is that our human body/brain can sometimes use meditative or other techniques to bootstrap to a level of metacognition that rests antecedent to - and can be the detached observer of - the generation of this illusion of a self and its purposes.

The maximum power of our self illusion, for most of us, goes with our heartfelt immersion and belief in it (i.e., our delusion). From such a immersion, it can be more difficult to discern or appreciate the different selves and purposes of other humans, and their cultures and historical eras.

Which way are you wagging your tail?

Blakeslee writes a review (PDF here) of work by Vallortigara et al (PDF here) on emotional asymmetric tail wagging by dogs that is a further reflection of lateralized functions of the brain. Some edited clips from her article:

In most animals, including birds, fish and frogs, the left brain specializes in behaviors involving what the scientists call approach and energy enrichment. In humans, that means the left brain is associated with positive feelings, like love, a sense of attachment, a feeling of safety and calm. It is also associated with physiological markers, like a slow heart rate.

At a fundamental level, the right brain specializes in behaviors involving withdrawal and energy expenditure. In humans, these behaviors, like fleeing, are associated with feelings like fear and depression. Physiological signals include a rapid heart rate and the shutdown of the digestive system.

Because the left brain controls the right side of the body and the right brain controls the left side of the body, such asymmetries are usually manifest in opposite sides of the body. Thus many birds seek food with their right eye (left brain/nourishment) and watch for predators with their left eye (right brain/danger).

In humans, the muscles on the right side of the face tend to reflect happiness (left brain) whereas muscles on the left side of the face reflect unhappiness (right brain).

Dog tails are interesting...because they are in the midline of the dog’s body, neither left nor right. So do they show emotional asymmetry, or not?

Vallortigara et al show that when dogs were attracted to something, including a benign, approachable cat, their tails wagged right, and when they were fearful, their tails went left. It suggests that the muscles in the right side of the tail reflect positive emotions while the muscles in the left side express negative ones.

Brain asymmetry for approach and withdrawal seems to be an ancient trait..Thus it must confer some sort of survival advantage on organisms.

Animals that can do two important things at the same time, like eat and watch for predators, might be better off. And animals with two brain hemispheres could avoid duplication of function, making maximal use of neural tissue.

The asymmetry may also arise from how major nerves in the body connect up to the brain... Nerves that carry information from the skin, heart, liver, lungs and other internal organs are inherently asymmetrical, he said. Thus information from the body that prompts an animal to slow down, eat, relax and restore itself is biased toward the left brain. Information from the body that tells an animal to run, fight, breathe faster and look out for danger is biased toward the right brain.

(This is a re-posting of the MindBlog post of 4/27/2007, material as interesting and fresh today as it was then.)

Response to climate change...."Managed Retreat"

This PNAS Core Concepts article by John Carey is worth a read. Here is its beginning:

As climate change causes seas to rise and fuels ever-stronger storms and droughts, humanity faces a stark choice. Communities can seek shelter from rising waters and battering storm surges by building fortifications such as the sea walls planned in Boston or Miami. Or people can figure out how to live with the new climate reality, such as by perching homes on 10-foot stilts on the North Carolina coast to stay high and dry above surging storm waves. Or they opt for a third option that’s increasingly getting attention: “managed retreat” away from the problem area. Managed retreat is “the purposeful, coordinated movement of people and assets out of harm’s way,”

Carey notes historical examples of moving entire towns or neighborhoods to safety away from high water or highway construction...

So what’s different now? Put simply, climate change. Sea levels could climb as much as six feet or more by century’s end, inundating hundreds of coastal cities, and intense storms and floods, heat waves, and wildfires are already striking communities around the globe. Unlike in the past, the number of people who will be forced to move is likely in the hundreds of millions—more than 300 million globally by 2050 just from sea level rise alone—according to new, more precise measurements of land heights that show that more people than previously thought are living just a few feet above sea level. To meet that staggering challenge, the historical pattern of relocations—typically just a few homes at a time, largely ad hoc, and almost invariably after a disaster has left a trail of damage and destruction—is woefully inadequate, researchers say. Relocations now and in the future must be many orders of magnitude larger in number and size, and, ideally, proactive rather than reactive. That means a tremendous increase in the need for managed retreat.

Five Epic Crises All at Once - David Brooks

I've been preparing a few summaries for a meeting this coming Sunday of The Austin Rainbow Forum, a senior group that discusses current topics and ideas. The topic for the meeting is "Possible Futures - The World after Coronavirus." I thought I would pass on what I'm putting in a slide showing a truncated version of David Brooks' recent Op-Ed piece in the NYTimes. His five epic crises:

1 - we are losing the fight against Covid-19. Our behavior doesn’t have anything to do with the reality around us. We just got tired so we’re giving up.

2 - Americans... are undergoing a rapid education on the burdens African-Americans carry every day...already public opinion is shifting with astonishing speed.

3 - we’re in the middle of a political realignment. The American public is vehemently rejecting Donald Trump’s Republican Party.

4 - a quasi-religion, Social Justice, is seeking control of America’s cultural institutions...Viewpoints are not explorations of truth, but weapons that dominant groups use to maintain their place in the power structure. Words can thus be a form of violence that has to be regulated.

5 - we are on the verge of a prolonged economic depression.

The Social Justice methodology is ultimately not a solution to our problem, it’s a symptom of our problem. Over the last half century, we’ve turned politics from a practical way to solve common problems into a cultural arena to display resentments. Donald Trump is the ultimate performer in this paralyzed arena.

...thank God that Joe Biden is going to be nominated by the Democratic Party. He came to public life when it wasn’t about performing your zeal, it was about crafting coalitions and legislating. He exudes a spirit that is about empathy and friendship not animosity and canceling. The pragmatic spirit of the New Deal is a more apt guide for the years ahead than the spirit of critical theory symbology.

Feeling bad is not bad.

MindBlog is passing on the link to each of Arthur Brooks' biweekly articles in his series "How to Build a Life". This latest installment deals with negative emotions, using them to grow and develop resilience rather than pushing them away. It is more difficult to summarize in a tidy way as I have some previous installments in the series. I suggest you read the whole piece. I will note the last two paragraphs:

One last thought: In 2019, the comedian Stephen Colbert was asked in an interview by CNN’s Anderson Cooper about a plane crash that killed Colbert’s father and two of his brothers when he was 10 years old. Cooper quoted a previous statement by Colbert that he had learned to “love the thing that I most wish had not happened.” He asked Colbert to clarify this extraordinary remark. “It’s a gift to exist, and with existence comes suffering,” Colbert replied. “I don’t want it to have happened … but if you are grateful for your life … then you have to be grateful for all of it. You can’t pick and choose what you’re grateful for.”

Colbert’s words resonated deeply with me, and perhaps they do with you, too. No normal person skips merrily into a tragic loss, nor usually seeks out even minor discomfort. But those things find us, over and over again in life. This is especially true today, in the era of COVID-19. The meaning from this pain, and the benefits it can bring to our lives and society, comes from how we choose to use it.

MindBlog's half-sour pickle recipe

This posting falls under the "random curious stuff" category mentioned in the title box of this blog. At the social/musical at my Twin Valley home on June 29*, several people asked for the recipe for the half-sour pickles we had served with gazpacho as a garnish. Here it is, the result of several trials to get them the way I like them. Not guaranteed to please all....

Deric's final half sour pickle recipe:

-2 lbs pickling cucumbers
-1 bundle of dill heads and stalks
-Wash cukes and dill, cut dill stalks to ~2-3 inch lengths, cut ends off cukes, slice cukes lengthwise if they are large.
-layer dill and cukes in container (~2 quart jar or plastic container)
-pour in water to cover, then pour this water into quart (4 cup) measuring cup to determine its volume, i.e. the desired volume for the pickling mixture to be added (should be ~ 4 cups).
-add 1/4 cup sea or kosher or pickling salt to 2 cups water, dissolve
-add 1/3 cup rice wine vinegar (or other very mild vinegar), 1/2 teaspoon whole black peppercorns, 3-4 whole coriander seeds, 1/2 teaspoon mustard seeds, 4-6 cloves fresh garlic, finely chopped.
-add water to obtain the volume determined above (~4 cups) while mixing thoroughly and pour over pickles.
-rotate jar or container at intervals to mix thoroughly, leave two days at room temperature, until a few bubbles start to appear, then put in refrigerator.
-pickles should be ready to eat after ~ 4 days, flavor improves over two weeks.

*(Note: I just made this recipe a few days ago from pickling cucumbers in our garden at my Austin Texas home.  Then I came across this post from 6/29/2008...done after a social occasional at my former Wisconsin home,  and decided to re-post it here.  As I look back over old posts during my COVID-19 mandated leisure, I notice that I used to do many more personal posts like this.)

The pandemic has put history on fast-forward.

Edited clips from Ross Douthat's NYTimes Op-Ed piece, suggesting that:

...when the coronavirus era finally ends, there will be a Rip Van Winkle feeling — a sense of having been asleep and waking to normality, except that we will have time-traveled and the normality will resemble the year 2030 as it might have been without the virus, rather than just a simple turn to 2021 or 2022.

-Key cultural institutions will have been increasingly consolidated and concentrated, academia and journalism especially

-Institutional churches will have faced falling donations and shrunken attendance, accelerating decay that awaited them with the next decade’s worth of generational turnover.

-In politics, what was likely to be a slow-motion leftward shift in politics, as the less-married, less-religious, more ethnically diverse younger generation gained more power, will have been accelerated nationally by the catastrophes of the Trump administration, putting states in play for Democrats five or 10 years early.

-In corporate America, there may have been trends toward both consolidation and dispersal. The former, because even federal intervention probably won’t prevent small businesses from going under, the second because the remote-work experience, pandemic fears and possibly-rising crime rates may encourage more companies to disperse talent back into the heartland for the first time in two generations.

...only this last one seems like a hopeful sign that post-pandemic America might become less sclerotic, less decadent than the America of 2019. If one wanted to be especially optimistic, one could add that maybe — maybe — a corporate dispersal will reduce social stratification, and help create new intellectual, journalistic and even religious centers.

Vote-by-mail has no impact on partisan turnout or vote share

Some factual data from Thompson et al. which we can be sure will be ignored by those trying to suppress voting by opposing mail in ballots:  

Significance

In response to COVID-19, many scholars and policy makers are urging the United States to expand voting-by-mail programs to safeguard the electoral process, but there are concerns that such a policy could favor one party over the other. We estimate the effects of universal vote-by-mail, a policy under which every voter is mailed a ballot in advance of the election, on partisan election outcomes. We find that universal vote-by-mail does not affect either party’s share of turnout or either party’s vote share. These conclusions support the conventional wisdom of election administration experts and contradict many popular claims in the media. Our results imply that the partisan outcomes of vote-by-mail elections closely resemble in-person elections, at least in normal times.

Abstract

In response to coronavirus disease 2019 (COVID-19), many scholars and policy makers are urging the United States to expand voting-by-mail programs to safeguard the electoral process. What are the effects of vote-by-mail? In this paper, we provide a comprehensive design-based analysis of the effect of universal vote-by-mail—a policy under which every voter is mailed a ballot in advance of the election—on electoral outcomes. We collect data from 1996 to 2018 on all three US states that implemented universal vote-by-mail in a staggered fashion across counties, allowing us to use a difference-in-differences design at the county level to estimate causal effects. We find that 1) universal vote-by-mail does not appear to affect either party’s share of turnout, 2) universal vote-by-mail does not appear to increase either party’s vote share, and 3) universal vote-by-mail modestly increases overall average turnout rates, in line with previous estimates. All three conclusions support the conventional wisdom of election administration experts and contradict many popular claims in the media.

The University Is Like a CD in the Streaming Age

Having lectured in university classrooms for about 40 years, but not since 2005, I am blown away by changes in the academy that technology has wrought since then. In an Atlantic article, Michael D. Smith, Professor of information technology and marketing at Carnegie Mellon University, describes how colleges, like the entertainment industry, will need to embrace digital services in order to survive. I pass on a few clips, and suggest you read the whole article.

Universities have long been remarkably stable institutions — so stable that in 2001, by one account, they comprised an astonishing 70 of the 85 institutions in the West that have endured in recognizable form since the 1520s...That stability has ... bred overconfidence, overpricing, and an overreliance on business models tailored to a physical world. Like ... entertainment executives did, many of us in higher education dismiss the threats that digital technologies pose to the way we work. We diminish online-learning and credentialing platforms such as Khan Academy, Kaggle, and edX as poor substitutes for the “real thing.” We can’t imagine that “our” students would ever want to take a DIY approach to their education instead of paying us for the privilege of learning in our hallowed halls. We can’t imagine “our” employers hiring someone who doesn’t have one of our respected degrees.

But we’re going to have to start thinking differently.

...this past semester, the coronavirus pandemic transformed distance learning from a quaint side product that few elite schools took seriously to a central part of our degree-granting programs. Arguments for the inherent superiority of the residential college experience will be less convincing now that we’ve conferred the same credentials—and charged the same tuition—for education delivered remotely.

Do students think their pricey degrees [from prestigious private universities] are worth the cost when delivered remotely?

The Wall Street Journal asked that question in April, and one student responded with this zinger: “Would you pay $75,000 for front-row seats to a Beyoncé concert and be satisfied with a livestream instead?”

...the core mission of higher education...in my view...is simple: As educators, we strive to create opportunities for as many students as possible to discover and develop their talents, and to use those talents to make a difference in the world.

By that measure, our current model falls short. Elite colleges talk about helping our students flourish in society, but our tuition prices leave many of them drowning in debt—or unable to enroll in the first place. We talk about creating opportunities for students, but we measure our success based on selectivity, which is little more than a celebration of the number of students we exclude from the elite-campus experience. We talk about preparing students for careers after graduation, but a 2014 Gallup survey found that only 11 percent of business leaders believed “college graduates have the skills and competencies that their workplaces need.” We talk about creating diverse campuses, but, as recent admissions scandals have made painfully clear, our admissions processes overwhelmingly favor the privileged few.

What if new technologies could allow us to understand the varied backgrounds, goals, and learning styles of our students—and provide educational material customized to their unique needs? What if we could deliver education to students via on-demand platforms that allowed them to study whenever, wherever, and whatever they desired, instead of requiring them to conform to the “broadcast” schedule of today’s education model? What if the economies of scale available from digital delivery allowed us to radically lower the price of our educational resources, creating opportunities for learners we previously excluded from our finely manicured quads? Might we discover, as the entertainment industry has, a wealth of talented individuals with valuable contributions to make who just didn’t fit into the rigid constraints of our old model?

I believe we will, but that doesn’t mean the residential university will go away. Indeed, these changes may allow universities to jettison “anti-intellectual” professional-degree programs in favor of a renewed focus on a classical liberal-arts education. But as this happens, we might discover that the market for students interested in spending four years and thousands of dollars on a broad foundation in the humanities is smaller than we believe—certainly not large enough to support the 5,000 or so college campuses in the United States today. Soon, residential colleges may experience a decline similar to that of live theaters after the advent of movies and broadcast television. Broadway and local playhouses still exist, but they are now considered exclusive and expensive forms of entertainment, nowhere near the cultural force they once were.

But remember, just because new technology changed the way entertainment was delivered doesn’t mean it impeded the industry’s underlying mission. Instead of destroying TV, movies, and books, new technologies have produced an explosion in creative output, delivered through the convenience, personalization, and interactivity of Kindle libraries, Netflix recommendations, and Spotify playlists. Despite—or maybe because of—the digital disruption we’ve recently lived through, we’re now enjoying a golden age of entertainment.

Whether we like it or not, big changes are coming to higher education. Instead of dismissing them or denying that they’re happening, let’s embrace them and see where they can take us. We have a chance today to reimagine an old model that has fallen far behind the times. If we do it right, we might even usher in a new golden age of education.

MindBlog statistics.

I'm a complete dunce at paying attention to or understanding the number of people who make use of Deric's Mindblog, which started in 2006. Yesterday I clicked on "analytics" in the blogger platform I use (the bottom graphic), and also looked at what feedburner.google.com says about traffic at mindblog.dericbownds.net (the top two graphics). In the all time history the latter reports ~5.5 million page views, while the former reports ~1.8 million. Whatever.... I'm doing this post to show these numbers for my future reference (click to enlarge figure). 

Stephen Wolfram - Computation All the Way Down

I not sure I really grok this, but if you want big thinking, here you go...... This edge.org link takes you to Wolfram's whole essay. Here's the abstract:

We're now in this situation where people just assume that science can compute everything, that if we have all the right input data and we have the right models, science will figure it out. If we learn that our universe is fundamentally computational, that throws us right into the idea that computation is a paradigm you have to care about. The big transition was from using equations to describe how everything works to using programs and computation to describe how things work. And that's a transition that has happened after 300 years of equations. The transition time to using programs has been remarkably quick, a decade or two. One area that was a holdout, despite the transition of many fields of science into the computational models direction, was fundamental physics.

If we can firmly establish this fundamental theory of physics, we know it's computation all the way down. Once we know it's computation all the way down, we're forced to think about it computationally. One of the consequences of thinking about things computationally is this phenomenon of computational irreducibility. You can't get around it. That means we have always had the point of view that science will eventually figure out everything, but computational irreducibility says that can't work. It says that even if we know the rules for the system, it may be the case that we can't work out what that system will do any more efficiently than basically just running the system and seeing what happens, just doing the experiment so to speak. We can't have a predictive theoretical science of what's going to happen.

10 reasons why a 'Greater Depression' for the 2020s is inevitable.

Try to hang on to any threads of optimism you might still have as I summarize,from an article in The Guardian by Nouriel Roubini, 10 ominous and risky trends:

-Soaring levels of public and private debts, and their corollary risks of defaults, all but ensure a more anemic recovery than the one that followed the Great Recession a decade ago.

-The demographic timebomb in advanced economies with ageing societies means more public spending (and debt) allocated to health systems.

-Deflation risk is increasing as COVID crisis creates massive unused capacity, unemployment, and commodities (oil, metals) price collapse, making debt deflation likely, increasing insolvency.

-As central banks run monetised fiscal deficits to avoid depression and deflation, currency will be debased and accelerated deglobalisation and renewed protectionism will make stagflation all but inevitable.

-Income and wealth gaps will widen as production is re-shored to guard against future supply-chain shocks, accelerating the rate of automation and downward pressure on wages, further fanning the flames of populism, nationalism, and xenophobia.

-The current deglobalisation trend, accelerated by the pandemic, will lead to tighter restrictions on the movement of goods, services, capital, labour, technology, data, and information.

-A populist backlash against democracy will reinforce this trend, as blue collar and middle class workers become more susceptible to poplulist rhetoric, scapegoating foreigners for the crisis, and supporting restriction of migration and trade.

-A geostrategic standoff between the US and China will cause decoupling in trade, technology, investment, data, and monetary arrangements to intensify.

--This diplomatic breakup will set the stage for a new cold war between the US and its rivals (China, Russia, Iran, North Korea) and because technology is the key weapon for controlling future industries and pandemics, the US private tech sector will be increasingly integrated into the national-security-industrial complex.

-A final risk that cannot be ignored is environmental disruption, which, as the Covid-19 crisis has shown, can wreak far more economic havoc than a financial crisis.

These 10 risks, already looming large before Covid-19 struck, now threaten to fuel a perfect storm that sweeps the entire global economy into a decade of despair. By the 2030s, technology and more competent political leadership may be able to reduce, resolve, or minimise many of these problems, giving rise to a more inclusive, cooperative, and stable international order. But any happy ending assumes that we find a way to survive the coming Greater Depression.

Why have stocks been rising.?

I pass on clips that cook down the main points from Derek Thompson's recent article that makes several clarifying points:

The COVID-19 crisis is simultaneously thrusting Americans into the pre-urban homestead economy of the 1830s, re-creating the Depression-era joblessness of the 1930s, and pulling forward the virtual economy of the 2030s. We are living in the weirdest economy ever.

Reason 1. ...the economy is not really “broken,” a global pathogenic pulse...has suddenly interrupted an otherwise normally functioning economy. That means we can’t solve the economic crisis until we solve the public-health crisis. That’s why stocks have jumped...every cheery vaccine headline is a corporate-equity stimulus.

Reason 2 ...this crisis combines an unprecedented shutdown of the physical economy with an unprecedented federal effort to distribute emergency cash to tens of millions of families...With millions of Americans earning more in unemployment than they were at work, personal income soared in April by 10 percent.

Reason 3 ...although retail is in the toilet, just about everything that has to do with housing is fine...The plague economy is extraordinarily unequal. Many high-income workers can afford to buy new homes because they are, for now, inoculated from the economic devastation by virtue of the fact that they can do their jobs from home...Digital technology’s insulation from the physical world might be the most durable aspect of this crisis...The at-home economy has diverged from the out-of-home economy. The stock market has diverged from the labor market. And the technology sector has, for now, accelerated into the future, breaking away from many other publicly traded companies.

...today’s economy is that of 1830, 1930, and 2030, all at once... What year will it be tomorrow?

The molecular choreography of acute exercise

Reynolds points to work of Contrepois et al, who had 36 volunteers, age range 40-75, complete a standard treadmill endurance test, running at an increasing intensity until exhaustion, usually after about nine or 10 minutes of exercise. Blood was drawn before, immediately after, and again 15, 30 and 60 minutes later. The measured the levels of 17,662 different molecules. Of these, 9,815 — or more than half — changed after exercise, compared to their levels before the workout.

Highlights

• Time-series analysis reveals an orchestrated molecular choreography of exercise

• Multi-level omic associations identify key biological processes of peak VO 2

• Prediction models highlight resting blood biomarkers of fitness

• Exercise omics provides insights into the pathophysiology of insulin resistance

Summary

Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptom-limited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting blood-based biomarkers of peak oxygen consumption.

Nostalgia... Remember Disco??

On my current tour through old MindBlog posts I came across this one from Jan 24, 2018, done during my early snowbird years in Fort Lauderdale, good energy to recal:

I saw this video (So Many Men, So Little Time - Miquel Brown) during happy hour at the local bar (Georgie's Alibi) several evenings ago and was totally transported back to my days of disco dancing in the late 1970's, early 1980's, getting hot and sweaty, tearing off the shirt, etc. The same moves at my current age would probably be life-threatening. I'll bet a number of you remember this kind of energy...

Jon Stewart weighs back in.....

I was struck by bits of clarity in David Marchese's interview of Jon Stewart. The interview was occasioned by the upcoming release of Stewart's satirical new movie "Irresistible." I want to pass on some clips of comments by Stewart that I made for myself:

Twenty-four-hour news networks are built for one thing, and that’s 9/11. There are very few events that would justify being covered 24 hours a day, seven days a week. So in the absence of urgency, they have to create it. You create urgency through conflict.

We continue to make this about the police — the how of it. How can they police? Is it about sensitivity and de-escalation training and community policing? All that can make for a less-egregious relationship between the police and people of color. But the how isn’t as important as the why, which we never address. The police are a reflection of a society. They’re not a rogue alien organization that came down to torment the black community. They’re enforcing segregation. Segregation is legally over, but it never ended. The police are, in some respects, a border patrol, and they patrol the border between the two Americas. We have that so that the rest of us don’t have to deal with it. Then that situation erupts, and we express our shock and indignation. But if we don’t address the anguish of a people, the pain of being a people who built this country through forced labor — people say, ‘‘I’m tired of everything being about race.’’ Well, imagine how [expletive] exhausting it is to live that.

There’s not a white person out there who would want to be treated like even a successful black person in this country. And if we don’t address the why of that treatment, the how is just window dressing. You know, we’re in a bizarre time of quarantine. White people lasted six weeks and then stormed a state building with rifles, shouting: ‘‘Give me liberty! This is causing economic distress! I’m not going to wear a mask, because that’s tyranny!’’ That’s six weeks versus 400 years of quarantining a race of people. The policing is an issue, but it’s the least of it. We use the police as surrogates to quarantine these racial and economic inequalities so that we don’t have to deal with them.

...there’s no oxygen for the campaign other than the oxygen that Trump’s Twitter feed puts into things. And no matter what, Trump has defined the terms of the fight. It’s going to be: What is America’s greatness? You have to fight on those terms, and that’s an opportunity to define what you believe is our greatness. Now, that’s not to say the political consultants won’t say to Biden, ‘‘You need to define your own lane.’’ But he doesn’t. The road is built.

What is broken about Washington isn’t the bureaucracy. It’s legislators’ ability to address the issues inherent in any society — and the reason they can’t address them is that when you have a duopoly, there is no incentive to work together to create something better. Plus, you have one party whose premise is that government is bad and whose goal is to prove that, which makes them, in essence, a double agent. All these things coalesce to make problem-solving the antithesis of what we’ve created. We’re incentivized for more extreme candidates, for more extreme partisanship, for more conflict and permanent campaigning, for corporate interests to have more influence on the process, not less.

‘‘The Daily Show’’ was a critique of the news and a critique of those systems [News intertwined with Entertainment]. If they’d taken in what we were saying, they wouldn’t be doing what they’re doing now: creating urgency through conflict. Conflict has become the catalyst for the economic model. The entire system functions that way now. We are two sides — in a country of 350 million people.

I don’t think it [the news media] has ever had a good handle on a political moment. It’s not designed for that. It’s designed for engagement. It’s like YouTube and Facebook: an information-laundering perpetual-radicalization machine. It’s like porn. I don’t mean that to be flip...The algorithm is not designed for thoughtful engagement and clarity. It’s designed to make you look at it longer.

The media’s job is to deconstruct the manipulation, not to just call it a lie. It’s about informing on how something works so that you understand the lie’s purpose. What are the structural issues underneath the lie? The media shouldn’t take the political system personally, or allow its own narcissism to rise to the narcissism of the politicians, or become offended that the politicians are lying — their job is to manipulate.

...I think he [Trump] understands very well — and the right understands very well — that undermining the credibility of the institutions that people look to for help defining and making sense of reality is the key to bending reality to your will. It’s a wonderful rhetorical trick. He had a great one on Memorial Day weekend:‘‘We’re getting great reviews on our pandemic response. But of course, not getting credit for it.’’ The twisted logic of that: If you’re getting great reviews, I’m pretty sure that’s considered credit. It’s like saying, ‘‘I’m being praised, but of course I won’t be praised for it.’’ Language is utterly meaningless. Everything is placed into its category in the tribal war and who its real victims are: Donald Trump and his minions. Poor little billionaire president who can’t catch a break. It’s incredible. Are we all just extras in this guy’s movie? But I do feel as if his approach has worked for him his whole life.

There’s all this talk of being on the right side of history, but what does that mean? ‘‘The arc of moral universe is long, but it bends toward justice.’’ Who’s bending it? What are we doing to further that? If you just get rid of Trump, that doesn’t end this. It’s too easy to say: ‘‘I support this other guy. Therefore, I’m part of the solution.’’ Or: ‘‘You support that guy. Therefore, you’re the problem.’’ Now, that is in no way exculpatory to the supporters of those policies or that regime. My point was: What does that judgment get you? What is the accountability that we have for those who really do believe this is unjust but still accept the tacit societal arrangements?

...the view we get of the country is not accurate. We get the artifice of it, the conflict of it. I’m not naïve. I don’t think that true divisions and animosities and bigotry and prejudices don’t exist. We see that every day. But fundamentally, we are a resilient and strong and resourceful nation that has oftentimes overcome our worst tendencies — ‘‘overcome’’ is probably too strong a word. But our biggest problem as humans is ignorance, not malevolence. Ignorance is an entirely curable disease...You need to talk to people. Ignorance is often cured by experience, by spending time with what you don’t understand...In the same way that Trump’s recklessness is born out of experience, so is my optimism, because good people outweigh [expletive] people. By a long shot.

Rich and Poor

San Paulo, Brazil.

Motion aftereffect demonstration

I'm passing this on, a rather powerful (practically hallucinatory) demonstration. Look at the center of the moving lines for 20 seconds and then at a picture on the wall. DO NOT TRY THIS IF YOU HAVE PHOTOSENSITIVE EPILEPSY!