Predicting child temperament - genes, brain and behavior

Work from Schmidt et al. on correlations between frontal EEG asymmetry, variations in a dopamine receptor gene, and later temperament:

Gene-environment interactions involving exogenous environmental factors are known to shape behavior and personality development. Although gene-environment interactions involving endogenous environmental factors are hypothesized to play an equally important role, this conceptual approach has not been empirically applied in the study of early-developing temperament in humans. Here we report evidence for a gene-endoenvironment (i.e., resting frontal brain electroencephalogram, EEG, asymmetry) interaction in predicting child temperament. The dopamine D4 receptor (DRD4) gene (long allele vs. short allele) moderated the relation between resting frontal EEG asymmetry (left vs. right) at 9 months and temperament at 48 months. Children who exhibited left frontal EEG asymmetry at 9 months and who possessed the DRD4 long allele were significantly more soothable at 48 months than other children. Among children with right frontal EEG asymmetry at 9 months, those with the DRD4 long allele had significantly more difficulties focusing and sustaining attention at 48 months than those with the DRD4 short allele. Resting frontal EEG asymmetry did not influence temperament in the absence of the DRD4 long allele. We discuss how the interaction of genetic and endoenvironmental factors may confer risk and protection for different behavioral styles in children.

Multitasking - bad for the brain?

From the random samples section of the Aug. 28 issue of Science, reporting unsettling news from one of the first-ever studies of chronic multitaskers:

A team headed by psychologist Eyal Ophir compared 19 "heavy media multitaskers" (HMMs), identified by questionnaires on media use, with 22 "light media multitaskers" (LMMs). They tested how well the subjects could filter relevant information from the environment, filter relevant information in their memories, and quickly switch cognitive tasks. One filtering test, for example, required viewers to note changes in red rectangles while ignoring blue rectangles in the same pictures.

HMMs did worse than LMMs across the board. Surprisingly, says co-author Clifford Nass, "they're bad at every cognitive control task necessary for multitasking." Nass, a sociologist, says the study has "disturbing" implications in an age when more and more people are simultaneously working on computers, listening to music, surfing the Web, and texting or talking on a phone. Also troubling, he notes, is that "people who chronically multitask believe they're good at it." The findings are reported this week in the Proceedings of the National Academy of Sciences.

The team hopes to investigate whether multitasking really scrambles brains or whether people with poor filtering and attentional abilities are more attracted to it to begin with. Psychologist Anthony Wagner suspects that media multitasking offers instant rewards that reinforce "exploratory" behavior at the expense of the ability to concentrate on a particular task.

Five second touch sufficient to convey emotion.

Bakalar reports on work of Herenstein and others who show the sophistication and rapidity of our human ability to communicate emotions such as anger, fear, happiness, sadness, disgust, love, gratitude or sympathy with a brief touch.

Our sense of smell is binaral.

When different images are presented to each of our two eyes, or different sounds to each of our two ears, our perception usually switches back and forth between the two alternatives. Now Zhou and Chen have found that the same applies to two odors separately presented to each nostril. This binaral rivalry involves both cortical and peripheral (olfactory receptor) adaptations. (If one of two odors is first presented to a nostril, and then after a brief interval it is again presented to the nostril while a second odor of equal initial power is presented to the other nostril, the second odor is predominantly sensed.)

Get aroused and be stronger.

From Schmidt et al.:

Effort magnitude is commonly thought to reflect motivation, but little is known about the influence of emotional factors. Here, we manipulated the emotional state of subjects, via the presentation of pictures, before they exerted physical effort (squeezing a hand grip) to win money. After highly arousing pictures, subjects produced more force and reported lower effort sensation, regardless of monetary incentives. Functional neuroimaging revealed that emotional arousal, as indexed by postscan ratings, specifically correlated with bilateral activity in the ventrolateral prefrontal cortex. We suggest that this region, by driving the motor cortex, constitutes a brain pathway that allows emotional arousal to facilitate physical effort.

Figure - The emotional incentive force task. Successive screens displayed in every trial are shown from left to right, with durations in milliseconds. Emotional pictures that could be neutral or arousing (with positive or negative valence) were shown before physical effort. Effort was triggered by simultaneously showing the amount of money at stake, materialized as coin images (1 cent, 10 cents, or 1 {euro}), and a thermometer in which fluid level represented the force exerted on the hand grip. Subjects knew that the top of the thermometer corresponded to the monetary incentive, such that the more they squeezed the hand grip, the more money they would win. The last screen informed subjects about the cumulative total of monetary earnings.

Oxytocin Increases Envy and Schadenfreude (Gloating)

Work from Shamay-Tsoory et al. suggests that oxytocin plays a role in a wider range of social emotion-related behaviors than just positive pro-social behaviors.

Fifty-six participants participated in a double-blind, placebo-controlled, within-subject study. Following the administration of oxytocin or a placebo, participants played a game of chance with another (fake) participant who either won more money (envy manipulation), lost more money (schadenfreude manipulation), or won/lost equal amounts of money. In comparison with the placebo, oxytocin increased the envy ratings during unequal monetary gain conditions involving relative loss (when the participant gained less money than another player). Oxytocin also increased the ratings of gloating during relative gain conditions (when the participant gained more money than the other player). By contrast, oxytocin had no effect on the emotional ratings following equal monetary gains nor did it affect general mood ratings.

More on "Running helps your knees?" and exercise

I received an email from Dan Peterson, reacting to my comment in my Aug. 27 post that I "feel strange if I have missed a day of going to the university gym to swim, run, or do weights." He had just done a story on a study by Robin Kanarek of Tufts University on the endorphin-fueled addictive qualities of running/exercise in rats. Here is Peterson's blog.

Monday musical offering - "Gade" from the lyrical pieces

The power of the press.

Chin, in the Editor's choice section of Science, notes work from Gerber et al. on the effects of newspapers:

A common belief in the United States is that the media exhibit a liberal bias, which generally aligns them with Democratic programs and politicians, in their reporting of the news and in their selection of what news to report on. In fact, one study estimates the effect of Fox News Channel, which was launched about a decade ago and is generally more conservative than other television outlets, as having increased the Republican share of the vote by half a percentage point.

One month before the November 2005 gubernatorial election in Virginia, Gerber et al. carried out a randomized field study in which several thousand households that did not already receive a daily newspaper were given trial subscriptions to either the Washington Post (liberal) or the Washington Times (conservative). Post-election telephone interviews established that receiving either newspaper had little impact on factual knowledge (such as Harriet Miers being a Supreme Court nominee) or political attitudes (such as President Bush's approval rating). What was affected was voter turnout (as measured by administrative records) and, surprisingly, actual voter choice, with both sets of newspaper-receiving households favoring the Democratic candidate by about seven percentage points.

Genes predicting our individual differences in exploration and exploitation

In the face of uncertainty, how do we choose between maintaining our current strategy or trying new strategies? A study From Frank et al. shows that a gene controlling prefrontal dopamine function is predictive of uncertainty-driven exploration:

The basal ganglia support learning to exploit decisions that have yielded positive outcomes in the past. In contrast, limited evidence implicates the prefrontal cortex in the process of making strategic exploratory decisions when the magnitude of potential outcomes is unknown. Here we examine neurogenetic contributions to individual differences in these distinct aspects of motivated human behavior, using a temporal decision-making task and computational analysis. We show that two genes controlling striatal dopamine function, DARPP-32 (also called PPP1R1B) and DRD2, are associated with exploitative learning to adjust response times incrementally as a function of positive and negative decision outcomes. In contrast, a gene primarily controlling prefrontal dopamine function (COMT) is associated with a particular type of 'directed exploration', in which exploratory decisions are made in proportion to Bayesian uncertainty about whether other choices might produce outcomes that are better than the status quo. Quantitative model fits reveal that genetic factors modulate independent parameters of a reinforcement learning system.

The biological residue of low early life social class.

A fascinating and sobering piece from Miller et al in the new issue of Proc. Nat. Acad. Sci.:

Children reared in unfavorable socioeconomic circumstances show increased susceptibility to the chronic diseases of aging when they reach the fifth and sixth decades of life. One mechanistic hypothesis for this phenomenon suggests that social adversity in early life programs biological systems in a manner that persists across decades and thereby accentuates vulnerability to disease. Here we examine the basic tenets of this hypothesis by performing genome-wide transcriptional profiling in healthy adults who were either low or high in socioeconomic status (SES) in early life. Among subjects with low early-life SES, there was significant up-regulation of genes bearing response elements for the CREB/ATF family of transcription factors that conveys adrenergic signals to leukocytes, and significant down-regulation of genes with response elements for the glucocorticoid receptor, which regulates the secretion of cortisol and transduces its antiinflammatory actions in the immune system. Subjects from low-SES backgrounds also showed increased output of cortisol in daily life, heightened expression of transcripts bearing response elements for NF-κB, and greater stimulated production of the proinflammatory cytokine interleukin 6. These disparities were independent of subjects' current SES, lifestyle practices, and perceived stress. Collectively, these data suggest that low early-life SES programs a defensive phenotype characterized by resistance to glucocorticoid signaling, which in turn facilitates exaggerated adrenocortical and inflammatory responses. Although these response patterns could serve adaptive functions during acute threats to well-being, over the long term they might exact an allostatic toll on the body that ultimately contributes to the chronic diseases of aging.

Comments on "Proust was a Neuroscientist"

I have been reading, in fits and starts, Jonah Leher's "Proust was a Neuroscientist," and just came across a review by Jonathan Bates that is consonant with my own opinions of the book:

The book is an elegant collection of essays—like Davis's extended essay, written in partial homage to William James—in which a range of 19th and early 20th century artists are shown to have discovered truths about the human mind ‘that science is only now rediscovering’ (pvii). Thus we get Walt Whitman on the ’embodied‘ nature of emotion (anticipating Antonio Damasio's work, which is so inspiring to scholars on the humanist side of the two cultures divide), Escoffier on the essence of taste, Cézanne on the process of sight, Gertrude Stein on the structure of language and so on. The focus is very much on the innovations of modernism. It would have been equally possibly to write a series of studies based on earlier anticipations—Wordsworth rather than Proust on memory, Keats rather than Whitman on the body—but that does not diminish the sharpness of the insights.

The book is worth its price for the chapter on Proust alone. This begins with some fairly obvious points, for instance that Proust was right to suppose that taste and smell are more powerful triggers for memory than sight, hearing and the self-conscious work of trying to remember something because they are ‘the only senses that connect directly to the hippocampus, the centre of the brain's long-term memory’ (p80). This explains the effect of the famous madeleine dipped into a cup of tea in Du côté de chez Swann. But Lehrer rapidly moves on to the much more interesting question of memory's fallibility. The key to A la Recherche du Temps Perdu is that past time is forever lost and that the search for it will always end in failure because of the fallibility of memory.

Lehrer contends that Proust intuited something that experimentation has now confirmed:

‘A memory is only as real as the last time you remembered it. The more you remember something, the less accurate the memory becomes ... every time we remember anything, the neuronal structure of the memory is delicately transformed, a process called reconsolidation ... So the purely objective memory, the one ‘true’ to the original taste of the madeleine, is the one memory you will never know. The moment you remember the cookie's taste is the same moment you forget what it really tasted like’ (p85).

Lehrer backs up this proposition with a fascinating account of some experiments on rats at New York University (Nader et al., 2000Go, 2004). Admittedly, this begs the question of the degree to which human memories work like rat memories. But the evidence does seem to support the profoundly Proustian idea that a memory is not like a photograph stored somewhere in the brain. Rather, ‘every memory is inseparable from the moment of its recollection: there simply is no way to describe the past without lying. Our memories are not like fiction. They are fiction’ (p88). This was a thought that Wordsworth got to before Proust: in his great autobiographical poem The Prelude, he wrestled with the question of the degree to which the feelings associated with his memories were invented by the very act of remembering.

Lehrer reminds us that the average half life of a brain protein is only 14 days. ‘The mind is in a constant state of reincarnation’ (p91). If the brain is constantly being reconstituted out of new cells, how do memories last? The chapter concludes with a tentative answer from Kausik Si's hypothesis that the ‘synaptic mark’ of memory is to be found in the cyptoplasmic polyadenylation element binding protein, which behaves very like a prion (Si et al., 2003Go). As is well-known from the huge challenge of research on mad cow disease, prions are virtually indestructible and ‘display an astonishing amount of plasticity’ (p93). Si's work remains controversial but it is, Lehrer claims, ‘the first hypothesis that begins to explain how sentimental ideas endure’. And the model is indeed remarkably Proustian.

....whilst there are new things about Shakespeare and Proust to be learnt by humanities scholars from brain science, so there are old things which Shakespeare and Proust can teach to brain scientists.

The poor payoff of pleasure postponed.

An interesting article describing work of Harvard Business School assistant professor Anat Keinan, in collaboration with Columbia Business School professor Ran Kivetz.

Keinan and Kivetz set out to see if they could observe, in formal studies, people overestimating discipline’s payoff and underestimating future feelings of having missed out. Time after time, when subjects were asked to recall situations in which they had to choose between work and pleasure, their responses emulated those of the Columbia doctoral students. More of the subjects who’d chosen play over work recently expressed regret, but those numbers reversed for choices made in the distant past. For instance, college students said they’d spent too much time relaxing during a recent winter break, but when they considered the previous year’s break, they said they’d spent too much time studying and working.

They call the habit of overestimating the benefits one will receive in the future from making responsible decisions now "hyperopia" - the name, drawn from ophthalmology, means “farsightedness.” It works to our detriment by driving people to underconsume precisely those products and experiences that they enjoy the most.

Guilt and atonement in child development.

Tierney does an interesting piece on work by Kochanska and colleagues showing how guilt in children, which usually appears during their second year, develops along side effortful self-control to inhibit impulsive behaviors that might hurt themselves or others. A deficit in either can be compensated by increased strength of the other, but a deficit in both guilt behavior and self-control increases the probability of sociopathic behaviors. To prevent guilt over a particular bad event from generalizing into shame (which has repeatedly been found to be unhealthy, as in "I'm a bad person"), it is important to have some sort of atonement process to round off the process. The article gives interesting examples of this process.

Running helps your knees?

I'm a physically active person, and feel strange if I have missed a day of going to the university gym to swim, run, or do weights. At 67 years of age I also fret about the point at which strengthening and healthy changes being to be overshadowed by inflamatory reactions in body joints. Thus I was struck by this piece in the NYTimes, reporting exactly the opposite of the conventional wisdom, namely that running is good for your knees. The article contains a link to some neat exercises for strengthening muscle than can take some of the load off the knee joint itself.

Anxious temperament correlates with serotonin transporter availability.

Richie Davidson, Ned Kalin, and their collaborators here at Wisconsin make interesting observations on a groups of rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament had previously been established. Here is their abstract:

The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [11C]DASB [11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.

Phantom

Grieg Lyric Pieces Op 62 no 5, Phantom

Aging may enhance procedural skill acquisition

While I notice that my short term memory is getting worse, I have felt (through my practicing and learning of new piano pieces) that my procedural learning capabilities are improving with age. In this light I found these observations from Brown et al. interesting:

It is well known that certain cognitive abilities decline with age. The ability to form certain new declarative memories, particularly memories for facts and events, has been widely shown to decline with advancing age. In contrast, the effects of aging on the ability to form new procedural memories such as skills are less well known, though it appears that older adults are able to acquire some new procedural skills over practice. The current study examines the effects of normal aging on procedural memory more closely by comparing the effects of aging on the encoding or acquisition stage of procedural learning versus its effects on the consolidation, or between-session stage of procedural learning. Twelve older and 14 young participants completed a sequence-learning task (the Serial Reaction Time Task) over a practice session and at a re-test session 24 hours later. Older participants actually demonstrated more sequence skill during acquisition than the young. However, older participants failed to show skill improvement at re-test as the young participants did. Age thus appears to have a differential effect upon procedural learning stages such that older adults' skill acquisition remains relatively intact, in some cases even superior, compared to that of young adults, while their skill consolidation may be poorer than that of young adults. Although the effect of normal aging on procedural consolidation remains unclear, aging may actually enhance skill acquisition on some procedural tasks.

Surowiecki on health care and status quo anxiety

In theory, the public overwhelmingly supports health care reform. James Surowiecki has a piece in the current New Yorker that suggests several reasons that they go all wobbly when it actually comes to making fundamental change. First is the "endowment effect" - the mere fact that you have something leads you to overvalue it. If people have insurance, most will value it highly, no matter how flawed the current system. Talk of changing the system accentuates the endowment effect. Last year a poll found that only 29% of likely voters found the US health care system good or excellent. When asked the same question last month 48% rated it highly, and health care delivery hadn't changed that much in the intervening 11 months! Adding to the endowment effect is the status quo bias. Most people are inclined to keep things the way they are. We feel the pain of losses more than we enjoy the pleasures of gain. So, when we think about change we focus more on what we might lose than what we might gain. Most people who don't feel good about the present system still feel anxious about whatever will replace it.

Surowiecki suggests that the key may be to work with, rather than against, people's desire for security. This is why Obama has repeatedly stressed that if people like the health care they have, they can keep it. Also, changing the system so that people can get affordable health care, while banning bad behavior on the part of insurance companies, will make it more likely that people can preserve their current level of coverage. The message should be that if we want to protect the status quo, we need to reform it.

An iPhone "Happiness" App

I've mentioned the work of Lyubomirsky in a previous post. She now has collaborated with people at Signal Patterns, a developer of psychology-based web and mobile applications, to generate an iPhone App meant to facilitate the basic exercises outlined in her book.