Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry. This hypothesis could unify diverse streams of pathophysiological and genetic evidence, but has not been susceptible to direct testing. Here we design and use several novel optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology. Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans. Consistent with the E/I balance hypothesis, compensatory elevation of inhibitory cell excitability partially rescued social deficits caused by E/I balance elevation. These results provide support for the elevated cellular E/I balance hypothesis of severe neuropsychiatric disease-related symptoms.
Thursday, August 25, 2011
Brain excitation/inhibition balance and social dysfunction
Yates does a review of recent work by Deisseroth and colleagues, who have now shown that in mice, an elevation in the excitation/inhibition ratio in the medial prefrontal cortex (mPFC) impairs cellular information processing and leads to specific behavioral impairments. They made, and then genetically inserted, different forms of opsin molecules in different excitatory and inhibitory neuronal mPFC populations. By flashing the cortex with different wavelengths of light they could increase levels of either excitation or inhibition. Here is their abstract: