Tuesday, February 09, 2021

How LSD tweaks our brain synapses to promote social behavior.

For the subset of MindBlog readers that is into the detailed Neuroscience of our behavior, I pass on an interesting article by De Gregorio et al. who use a mouse model to probe LSD's reported enhancement of empathy and social behavior in humans. Here is their significance statement, which is quite technical. If that's not enough for you, click on the link.
Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration of low doses of the 5-HT2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating 5-HT2A and AMPA receptor neurotransmission in the mPFC via an increasing phosphorylation of the mTORC1, a protein involved in the modulation of SB. Moreover, the inactivation of mPFC glutamate neurotransmission impairs SB and nullifies the prosocial effects of LSD. Finally, LSD requires the integrity of mTORC1 in excitatory glutamatergic, but not in inhibitory neurons, to produce prosocial effects. This study unveils a mechanism contributing to the role of 5-HT2A agonism in the modulation of SB.

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