Friday, February 24, 2006
Delete one gene, and turn from timid to daring, if you are a mouse
Can efforts to dial down overly fearful humans be far behind?
Shumyatsky et al. show that deleting a gene that is expressed in the amygdala (required for fear conditioning) generates mice that are less aversive to risk and less intimidated by dangerous sights and sounds. Curiously, the gene is for a protein, stathmin, that inhibits microtubule formation. With it gone, the electrical signals associated with fear conditioning are deficient.
Shumyatsky et al. show that deleting a gene that is expressed in the amygdala (required for fear conditioning) generates mice that are less aversive to risk and less intimidated by dangerous sights and sounds. Curiously, the gene is for a protein, stathmin, that inhibits microtubule formation. With it gone, the electrical signals associated with fear conditioning are deficient.
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Exciting research,Deleting genes is interesting thoughts.It is good to don't have fear in mind.
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