Nicotinamide adenine dinucleotide (NAD) is an important cofactor in numerous metabolic reactions. NAD concentrations decline with age, which may contribute to age-associated conditions such as Parkinson’s disease. Preclinical studies show that replenishing NAD by supplementation with nicotinamide riboside (NR), a biosynthetic precursor to NAD, can promote health span and neuroprotection. Brakedal et al. performed a randomized, double-blind phase 1 clinical trial of NR supplementation in 30 patients newly diagnosed with Parkinson’s disease. They found that NR supplementation was safe and that concentrations of NAD in the brain increased in most patients receiving NR. These patients had signs of altered cerebral metabolism and mild clinical improvement, although further testing is needed with a larger cohort to confirm any clinical benefit.Added note: I realized I had bought a jar of nicotinamide riboside some time ago ("TRU - Niagen" at an outrageious price), decided not to take it after reading about possible side effects, but relented after reading the Brakedal et al. article. I've been taking a 150 mg capsule daily for the past 10 days, half the recommended dosage. I haven't detected any noticable effects on my general energy levels.
Wednesday, March 30, 2022
Re-energizing the aged brain
Alderton does a brief summary of work by Brakedal et al.: