Novelty seeking is a key feature of intelligent behavior and adaptive cognition. However, we know little about the circuits that regulate our attraction to novel objects for novelty’s sake. Ogasawara et al. discovered that a brain nucleus called the zona incerta was causally related to novelty seeking. A region in the anterior medial temporal lobe projected to the zona incerta and sent motivational signals required to control novelty seeking through the zona incerta circuit. A novelty-seeking task, in which monkeys were motivated by the receipt of novel objects, showed that this behavior was not regulated by the dopamine reward-seeking circuitry. This work provides evidence for a clear dissociation in the brain circuitry between reward seeking and novelty seeking.
Monday, January 17, 2022
Different circuits in the brain for reward seeking and novelty seeking.
Work by Ogasawara et al. is noted by Peter Stern.