There’s a preprint from David Sinclair’s Harvard laboratory, posted on BioRxiv but not yet published, with very encouraging news for those of us who think that resetting the epigenetic (methylation) clock is a path to anti-aging. They suggest that 3 of the 4 Yamanaka factors, administered in short pulses, can set back the Horvath methylation clock without turning functioning tissues back into stem cells. The same study offers evidence to support the hypothesis that the epigenetic clock is a lethal driver of aging, rather than an adaptive response to damage.
Friday, December 20, 2019
Setting back our epigenic age?
I would like to point to Josh Mitteldorf's Blog "Aging Matters", in particular "Pulsed Yamanaka Factors Set Back Epigenic Age." A clip: